Open Access
Open access
Springer Nature
Surgical and Experimental Pathology
,  volume 7 ,  issue 1 ,  publication number 20

Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices

Antonio Luiz Pereira Siqueira Campos 1
, 
Luciana Campi Auresco 2
, 
Lidiane Vieira Marins 3
, 
Paulo Henrique do Amor Divino 2
, 
Jorge Sabbaga 2
, 
Paulo Marcelo Hoff 2
1
 
2
 
3
 
Laboratório de Patologia, Rede D’Or, São Paulo, Brasil | 
Publication type: Journal Article
Publication date: 2024-10-08
Springer Nature
SJR: —
CiteScore: —
Impact factor: —
ISSN: 25208454
Abstract

Predictive biomarkers of response to therapy are fundamental for the personalized therapeutic management of patients with colorectal carcinoma (CRC). The main predictive biomarkers related to CRC are the mismatch repair proteins/microsatellite instability status (MMR/MSI status), RAS/RAF mutation status and HER2 status. We discuss the scenarios in which these biomarkers are used and address different aspects that may affect the evaluation of each biomarker. We also address the increasingly recognized importance of circulating tumor DNA (ctDNA) testing in the management of stage II-III CRC as well as the role of the pathologist in this setting.

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Campos A. L. P. S. et al. Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices // Surgical and Experimental Pathology. 2024. Vol. 7. No. 1. 20
GOST all authors (up to 50) Copy
Campos A. L. P. S., Auresco L. C., Marins L. V., Divino P. H. D. A., Sabbaga J., Hoff P. M. Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices // Surgical and Experimental Pathology. 2024. Vol. 7. No. 1. 20
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RIS Copy
TY - JOUR
DO - 10.1186/s42047-024-00163-3
UR - https://surgexppathol.biomedcentral.com/articles/10.1186/s42047-024-00163-3
TI - Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices
T2 - Surgical and Experimental Pathology
AU - Campos, Antonio Luiz Pereira Siqueira
AU - Auresco, Luciana Campi
AU - Marins, Lidiane Vieira
AU - Divino, Paulo Henrique do Amor
AU - Sabbaga, Jorge
AU - Hoff, Paulo Marcelo
PY - 2024
DA - 2024/10/08
PB - Springer Nature
IS - 1
VL - 7
SN - 2520-8454
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Campos,
author = {Antonio Luiz Pereira Siqueira Campos and Luciana Campi Auresco and Lidiane Vieira Marins and Paulo Henrique do Amor Divino and Jorge Sabbaga and Paulo Marcelo Hoff},
title = {Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices},
journal = {Surgical and Experimental Pathology},
year = {2024},
volume = {7},
publisher = {Springer Nature},
month = {oct},
url = {https://surgexppathol.biomedcentral.com/articles/10.1186/s42047-024-00163-3},
number = {1},
pages = {20},
doi = {10.1186/s42047-024-00163-3}
}