Open Access
Open access
Springer Nature
Surgical and Experimental Pathology
,  volume 7 ,  issue 1 ,  publication number 24

Predictive biomarkers in daily anatomic pathology – is there something ready for sarcomas? A review and insights for future directions

Luiza Fadul Gallas 1
, 
André Morales Pacca 1
, 
Rodrigo De Andrade Natal 2, 3
1
 
2
 
3
 
Anatomic Pathology D’Or Hospital Network, São Paulo, Brazil | 
Publication type: Journal Article
Publication date: 2024-11-20
Springer Nature
SJR: —
CiteScore: —
Impact factor: —
ISSN: 25208454
Abstract

Sarcomas are tumors of mesenchymal origin that remain with poor prognosis. This review highlights some emerging predictive biomarkers that could drive personalized therapy, focusing on KIT, TP53, MDM2, CDK4 mutations, PRAME, INI1 and NF1. Research shows that there is a role for imatinib in some gastrointestinal stromal tumors with KIT mutations, and the TP53 mutation may someday serve as a biomarker to assist decision-making for neoadjuvant chemotherapy. Amplifications of MDM2 and CDK4 are currently targets for new therapeutical drugs. For PRAME, there is perspective for tumors with high CTA expression with some T-cell mediated therapies. INI1 loss can be a target for tazemetostat treatment in patients with advanced epithelioid sarcoma, and studies have shown a role for Selumetinib in patients with NF1 mutations related tumors.

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Gallas L. F. et al. Predictive biomarkers in daily anatomic pathology – is there something ready for sarcomas? A review and insights for future directions // Surgical and Experimental Pathology. 2024. Vol. 7. No. 1. 24
GOST all authors (up to 50) Copy
Gallas L. F., Pacca A. M., De Andrade Natal R. Predictive biomarkers in daily anatomic pathology – is there something ready for sarcomas? A review and insights for future directions // Surgical and Experimental Pathology. 2024. Vol. 7. No. 1. 24
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RIS Copy
TY - JOUR
DO - 10.1186/s42047-024-00168-y
UR - https://surgexppathol.biomedcentral.com/articles/10.1186/s42047-024-00168-y
TI - Predictive biomarkers in daily anatomic pathology – is there something ready for sarcomas? A review and insights for future directions
T2 - Surgical and Experimental Pathology
AU - Gallas, Luiza Fadul
AU - Pacca, André Morales
AU - De Andrade Natal, Rodrigo
PY - 2024
DA - 2024/11/20
PB - Springer Nature
IS - 1
VL - 7
SN - 2520-8454
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Gallas,
author = {Luiza Fadul Gallas and André Morales Pacca and Rodrigo De Andrade Natal},
title = {Predictive biomarkers in daily anatomic pathology – is there something ready for sarcomas? A review and insights for future directions},
journal = {Surgical and Experimental Pathology},
year = {2024},
volume = {7},
publisher = {Springer Nature},
month = {nov},
url = {https://surgexppathol.biomedcentral.com/articles/10.1186/s42047-024-00168-y},
number = {1},
pages = {24},
doi = {10.1186/s42047-024-00168-y}
}