Open Access
Open access
Critical Care, volume 14, issue 1, pages R15

Sepsis biomarkers: a review

Publication typeJournal Article
Publication date2010-03-11
Journal: Critical Care
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor15.1
ISSN13648535, 1466609X, 13648535, 18757081
Critical Care and Intensive Care Medicine
Abstract
Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy. We used an electronic search of the PubMed database using the key words "sepsis" and "biomarker" to identify clinical and experimental studies which evaluated a biomarker in sepsis. The search retrieved 3370 references covering 178 different biomarkers. Many biomarkers have been evaluated for use in sepsis. Most of the biomarkers had been tested clinically, primarily as prognostic markers in sepsis; relatively few have been used for diagnosis. None has sufficient specificity or sensitivity to be routinely employed in clinical practice. PCT and CRP have been most widely used, but even these have limited ability to distinguish sepsis from other inflammatory conditions or to predict outcome.

Top-30

Citations by journals

5
10
15
20
25
30
35
40
Critical Care
37 publications, 4.08%
PLoS ONE
33 publications, 3.64%
Scientific Reports
24 publications, 2.65%
Critical Care Medicine
22 publications, 2.43%
Shock
18 publications, 1.99%
Journal of Critical Care
17 publications, 1.88%
Frontiers in Immunology
14 publications, 1.55%
Mediators of Inflammation
11 publications, 1.21%
International Journal of Molecular Sciences
10 publications, 1.1%
Intensive Care Medicine
10 publications, 1.1%
BMC Infectious Diseases
8 publications, 0.88%
Annals of Intensive Care
8 publications, 0.88%
American Journal of Respiratory and Critical Care Medicine
7 publications, 0.77%
Journal of Infection
7 publications, 0.77%
Clinica Chimica Acta
7 publications, 0.77%
American Journal of Emergency Medicine
7 publications, 0.77%
BioMed Research International
7 publications, 0.77%
Cytokine
6 publications, 0.66%
Expert Review of Molecular Diagnostics
6 publications, 0.66%
BMJ Open
6 publications, 0.66%
Medicina
5 publications, 0.55%
Diagnostics
5 publications, 0.55%
Frontiers in Medicine
5 publications, 0.55%
Critical Care Clinics
5 publications, 0.55%
Journal of Clinical Laboratory Analysis
5 publications, 0.55%
The Analyst
5 publications, 0.55%
Lab on a Chip
5 publications, 0.55%
Scandinavian Journal of Clinical and Laboratory Investigation
5 publications, 0.55%
Annals of Translational Medicine
5 publications, 0.55%
5
10
15
20
25
30
35
40

Citations by publishers

20
40
60
80
100
120
140
160
180
200
Springer Nature
186 publications, 20.53%
Elsevier
177 publications, 19.54%
Wolters Kluwer Health
60 publications, 6.62%
Multidisciplinary Digital Publishing Institute (MDPI)
49 publications, 5.41%
Wiley
46 publications, 5.08%
Public Library of Science (PLoS)
37 publications, 4.08%
Taylor & Francis
33 publications, 3.64%
Frontiers Media S.A.
29 publications, 3.2%
Hindawi Limited
26 publications, 2.87%
SAGE
19 publications, 2.1%
Royal Society of Chemistry (RSC)
18 publications, 1.99%
AME Publishing Company
11 publications, 1.21%
Cold Spring Harbor Laboratory
10 publications, 1.1%
Oxford University Press
9 publications, 0.99%
BMJ
8 publications, 0.88%
American Thoracic Society
7 publications, 0.77%
Thieme
6 publications, 0.66%
Future Medicine
5 publications, 0.55%
Mary Ann Liebert
5 publications, 0.55%
Walter de Gruyter
5 publications, 0.55%
American Physiological Society
5 publications, 0.55%
American Chemical Society (ACS)
4 publications, 0.44%
American Society for Microbiology
4 publications, 0.44%
Research Square Platform LLC
4 publications, 0.44%
American Society for Biochemistry and Molecular Biology
3 publications, 0.33%
Dove Medical Press
3 publications, 0.33%
Cambridge University Press
3 publications, 0.33%
Medknow Publications
3 publications, 0.33%
The American Association of Immunologists
2 publications, 0.22%
20
40
60
80
100
120
140
160
180
200
  • We do not take into account publications without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Pierrakos C., Vincent J. Sepsis biomarkers: a review // Critical Care. 2010. Vol. 14. No. 1. p. R15.
GOST all authors (up to 50) Copy
Pierrakos C., Vincent J. Sepsis biomarkers: a review // Critical Care. 2010. Vol. 14. No. 1. p. R15.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1186/cc8872
UR - https://doi.org/10.1186/cc8872
TI - Sepsis biomarkers: a review
T2 - Critical Care
AU - Pierrakos, Charalampos
AU - Vincent, Jean-Louis
PY - 2010
DA - 2010/03/11 00:00:00
PB - Springer Nature
SP - R15
IS - 1
VL - 14
SN - 1364-8535
SN - 1466-609X
SN - 1364-8535
SN - 1875-7081
ER -
BibTex |
Cite this
BibTex Copy
@article{2010_Pierrakos,
author = {Charalampos Pierrakos and Jean-Louis Vincent},
title = {Sepsis biomarkers: a review},
journal = {Critical Care},
year = {2010},
volume = {14},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1186/cc8872},
number = {1},
pages = {R15},
doi = {10.1186/cc8872}
}
MLA
Cite this
MLA Copy
Pierrakos, Charalampos, and Jean-Louis Vincent. “Sepsis biomarkers: a review.” Critical Care, vol. 14, no. 1, Mar. 2010, p. R15. https://doi.org/10.1186/cc8872.
Found error?