Open Access
Open access
Springer Nature
Clinical Proteomics
,  volume 21 ,  issue 1 ,  publication number 35

Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy

Zhihua Li 1
, 
Junnan Chen 1
, 
Bin Xu 2
, 
Wei Zhao 1
, 
Haoran Zha 1
, 
Yalin Han 1
, 
Wennan Shen 1
, 
Yuemei Dong 1
, 
Nan Zhao 1
, 
Manze Zhang 1
, 
Kun He 2
, 
Zhaoxia Li 1
, 
Xiaoqing Liu 3
1
 
Department of Oncology, PLA Rocket Force Characteristic Medical Center, Beijing, China | 
2
 
National Center of Biomedical Analysis, Beijing, China | 
3
 
Publication type: Journal Article
Publication date: 2024-05-19
Springer Nature
scimago Q1
wos Q2
SJR: 0.962
CiteScore: 4.3
Impact factor: 3.3
ISSN: 15426416, 15590275
Abstract
Background

Currently, no effective measures are available to predict the curative efficacy of small-cell lung cancer (SCLC) chemotherapy. We expect to develop a method for effectively predicting the SCLC chemotherapy efficacy and prognosis in clinical practice in order to offer more pertinent therapeutic protocols for individual patients.

Methods

We adopted matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and ClinPro Tools system to detect serum samples from 154 SCLC patients with different curative efficacy of standard chemotherapy and analyze the different peptides/proteins of SCLC patients to discover predictive tumor markers related to chemotherapy efficacy. Ten peptide/protein peaks were significantly different in the two groups.

Results

A genetic algorithm model consisting of four peptides/proteins was developed from the training group to separate patients with different chemotherapy efficacies. Among them, three peptides/proteins (m/z 3323.35, 6649.03 and 6451.08) showed high expression in the disease progression group, whereas the peptide/protein at m/z 4283.18 was highly expressed in the disease response group. The classifier exhibited an accuracy of 91.4% (53/58) in the validation group. The survival analysis showed that the median progression-free survival (PFS) of 30 SCLC patients in disease response group was 9.0 months; in 28 cases in disease progression group, the median PFS was 3.0 months, a statistically significant difference (χ2 = 46.98, P < 0.001). The median overall survival (OS) of the two groups was 13.0 months and 7.0 months, a statistically significant difference (χ2 = 40.64, P < 0.001).

Conclusions

These peptides/proteins may be used as potential biological markers for prediction of the curative efficacy and prognosis for SCLC patients treated with standard regimen chemotherapy.

Found 
Found 

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Li Z. et al. Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy // Clinical Proteomics. 2024. Vol. 21. No. 1. 35
GOST all authors (up to 50) Copy
Li Z., Chen J., Xu B., Zhao W., Zha H., Han Y., Shen W., Dong Y., Zhao N., Zhang M., He K., Li Z., Liu X. Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy // Clinical Proteomics. 2024. Vol. 21. No. 1. 35
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RIS Copy
TY - JOUR
DO - 10.1186/s12014-024-09483-8
UR - https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-024-09483-8
TI - Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy
T2 - Clinical Proteomics
AU - Li, Zhihua
AU - Chen, Junnan
AU - Xu, Bin
AU - Zhao, Wei
AU - Zha, Haoran
AU - Han, Yalin
AU - Shen, Wennan
AU - Dong, Yuemei
AU - Zhao, Nan
AU - Zhang, Manze
AU - He, Kun
AU - Li, Zhaoxia
AU - Liu, Xiaoqing
PY - 2024
DA - 2024/05/19
PB - Springer Nature
IS - 1
VL - 21
PMID - 38764042
SN - 1542-6416
SN - 1559-0275
ER -
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Cite this
BibTex (up to 50 authors) Copy
@article{2024_Li,
author = {Zhihua Li and Junnan Chen and Bin Xu and Wei Zhao and Haoran Zha and Yalin Han and Wennan Shen and Yuemei Dong and Nan Zhao and Manze Zhang and Kun He and Zhaoxia Li and Xiaoqing Liu},
title = {Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy},
journal = {Clinical Proteomics},
year = {2024},
volume = {21},
publisher = {Springer Nature},
month = {may},
url = {https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-024-09483-8},
number = {1},
pages = {35},
doi = {10.1186/s12014-024-09483-8}
}