Open Access
Open access
Elsevier
Journal of Physiological Sciences
,  volume 74 ,  issue 1 ,  pages 54

Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats

Shumpei Tsukamoto 1, 2, 3
, 
Tomoya SAWAMURA 1, 2, 3
, 
Natsufu Yuki 1, 2, 3
, 
Kazuhiro Horii 4, 5, 6
, 
Yuuki Horii 1, 2, 3
, 
Takeshi Homma 7
, 
Shouichiro Saito 7
, 
Takahiko Shiina 2
, 
Yasutake Shimizu 1, 3, 8, 9, 10
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
Publication type: Journal Article
Publication date: 2024-11-22
Elsevier
scimago Q2
wos Q2
SJR: 0.791
CiteScore: 4.2
Impact factor: 3.2
ISSN: 18806546, 18806562
Abstract

We investigated the effects of a centrally penetrant ghrelin agonist, RQ-00538053, on colorectal motility in female rats in comparison with that in male rats. Intravenous administration of RQ-00538053 enhanced colorectal motility in female rats. However, approximately tenfold higher doses were required to induce responses in female rats similar to those in male rats. Higher doses were required even when the agonist was intrathecally administered to the lumbosacral spinal cord in female rats. The results of RT-qPCR showed that the level of ghrelin receptor expression in the lumbosacral spinal cord was lower in female rats than in male rats, suggesting that the lower expression level of the receptor may contribute, at least in part, to the sex differences in the action of RQ-00538053. The sexually dimorphic action of a ghrelin agonist will be important for future works aiming to utilize ghrelin agonists as novel drugs to improve constipation.

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Tsukamoto S. et al. Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats // Journal of Physiological Sciences. 2024. Vol. 74. No. 1. p. 54.
GOST all authors (up to 50) Copy
Tsukamoto S., SAWAMURA T., Yuki N., Horii K., Horii Y., Homma T., Saito S., Shiina T., Shimizu Y. Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats // Journal of Physiological Sciences. 2024. Vol. 74. No. 1. p. 54.
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TY - JOUR
DO - 10.1186/s12576-024-00949-w
UR - https://jps.biomedcentral.com/articles/10.1186/s12576-024-00949-w
TI - Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats
T2 - Journal of Physiological Sciences
AU - Tsukamoto, Shumpei
AU - SAWAMURA, Tomoya
AU - Yuki, Natsufu
AU - Horii, Kazuhiro
AU - Horii, Yuuki
AU - Homma, Takeshi
AU - Saito, Shouichiro
AU - Shiina, Takahiko
AU - Shimizu, Yasutake
PY - 2024
DA - 2024/11/22
PB - Elsevier
SP - 54
IS - 1
VL - 74
PMID - 39578725
SN - 1880-6546
SN - 1880-6562
ER -
BibTex |
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@article{2024_Tsukamoto,
author = {Shumpei Tsukamoto and Tomoya SAWAMURA and Natsufu Yuki and Kazuhiro Horii and Yuuki Horii and Takeshi Homma and Shouichiro Saito and Takahiko Shiina and Yasutake Shimizu},
title = {Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats},
journal = {Journal of Physiological Sciences},
year = {2024},
volume = {74},
publisher = {Elsevier},
month = {nov},
url = {https://jps.biomedcentral.com/articles/10.1186/s12576-024-00949-w},
number = {1},
pages = {54},
doi = {10.1186/s12576-024-00949-w}
}
MLA
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Tsukamoto, Shumpei, et al. “Sexual dimorphism in prokinetic effects of a ghrelin agonist acting through the lumbosacral defecation center in rats.” Journal of Physiological Sciences, vol. 74, no. 1, Nov. 2024, p. 54. https://jps.biomedcentral.com/articles/10.1186/s12576-024-00949-w.
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