Open Access

BMC Medicine

, volume 20 , issue 1 , publication number 244

Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

Ekaterina Pazukhina ^{1, 2}

Margarita Andreeva ³

Ekaterina Spiridonova ³

Polina Bobkova ³

Anastasia Shikhaleva ³

Yasmin El Taravi ³

Mikhail Rumyantsev ³

Aysylu Gamirova ³

Anastasiia Bairashevskaia ³

Polina Petrova ³

Dina Baimukhambetova ³

Maria Pikuza ³

Elina Abdeeva ³

Yulia Filippova ³

Salima Deunezhewa ³

Nikita Nekliudov ³

Polina Bugaeva ³

Nikolay Bulanov ⁴

Sergey Avdeev ⁵

Valentina Kapustina ⁶

Alla Guekht ^{7, 8}

Audrey DunnGalvin ^{3, 9}

Pasquale Comberiati ¹⁰

Diego G. Peroni ¹⁰

Christian Apfelbacher ¹¹

Jon Genuneit ¹²

Luis Felipe Reyes ^{13, 14}

Caroline L H Brackel ^{15, 16}

Victor Fomin ¹⁷

Andrey A. Svistunov ¹⁷

Peter Timashev ¹⁸

Lyudmila Mazankova ¹⁹

Alexandra Miroshina ²⁰

Elmira Samitova ^{19, 20}

Svetlana Borzakova ^{8, 21}

Elena Bondarenko ³

Anatoliy A Korsunskiy ³

Gail Carson ²²

Louise Sigfrid ²²

Janet T Scott ²³

Matthew Greenhawt ²⁴

Danilo Buonsenso ^{25, 26, 27}

Malcolm G Semple ^{28, 29}

John O. Warner ³⁰

Piero Olliaro ²²

Dale M. Needham ^{31, 32, 33}

Petr Glybochko ¹⁷

Denis Butnaru ¹⁷

Ismail M Osmanov ^{8, 20}

Daniel Munblit ^{3, 7, 30}

Hide authors affiliations Show authors affiliations: 33 affiliations

Laboratory of Health Economics, Institute of Applied Economic Studies, The Russian Presidential Academy of National Economy and Public Administration, Moscow, Russia |

Center for Advanced Financial Planning, Macroeconomic Analysis and Financial Statistics, Financial Research Institute of the Ministry of Finance of the Russian Federation, Moscow, Russia |

Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

⁴

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

⁵

Clinic of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

⁶

Department of Internal Medicine №1, Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

⁷

Research and Clinical Center for Neuropsychiatry, Moscow, Russia |

⁸

Pirogov Russian National Research Medical University, Moscow, Russia |

⁹

School of Applied Psychology, University College Cork, Cork City, Ireland |

¹⁰

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy |

¹¹

Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany |

¹²

Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany |

¹³

Universidad de la Sabana, Chía, Colombia |

¹⁴

Clínica Universidad de la Sabana, Chía, Colombia |

¹⁵

Department of Pediatric Pulmonology, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, the Netherlands |

¹⁶

Department of Pediatrics, Tergooi MC, Hilversum, the Netherlands |

¹⁷

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

¹⁸

Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia |

¹⁹

Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russia |

²⁰

ZA Bashlyaeva Children’s Municipal Clinical Hospital, Moscow, Russia |

²¹

Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, Moscow, Russia |

²²

Nuffield Department of Medicine, ISARIC Global Support Centre, University of Oxford, Oxford, UK |

²³

MRC-University of Glasgow Centre for Virus Research, Glasgow, UK |

²⁴

Department of Pediatrics, Section of Allergy/Immunology, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, USA

University of Colorado Anschutz Medical Campus

Children's Hospital Colorado

²⁵

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy |

²⁶

Dipartimento Di Scienze Biotecnologiche Di Base, Cliniche Intensivologiche E Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy |

²⁷

Center for Global Health Research and Studies, Università Cattolica del Sacro Cuore, Roma, Italia |

²⁸

Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK |

²⁹

Department of Respiratory Medicine, Alder Hey Children’s Hospital, Liverpool, UK |

³⁰

Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK |

³¹

Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, USA |

³²

Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA |

³³

Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, USA |

Publication type: Journal Article

Publication date: 2022-07-06

Springer Nature

BMC Medicine

scimago Q1

wos Q1

SJR: 2.846

CiteScore: 11.3

Impact factor: 8.3

ISSN: 17417015

DOI: 10.1186/s12916-022-02448-4

Copy DOI

PubMed ID: 35794549

General Medicine

Abstract

Background

Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors.

Methods

Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge.

Results

One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47).

Conclusions

Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.

Found

1 citation

Maslova Olga

19 publications, 112 citations

h-index: 6

Samara State Medical University

Symbiosis International University

1 citation

Subramanian Arunkumar

🤝

16 publications, 99 citations, 14 reviews

h-index: 6

SRM Institute of Science and Technology

Research interests

Neuropharmacology

Toxicology

1 citation

Gochhait Saikat

🥼 🤝

PhD, associate professor, honorary fellow of the Russian Academy of Sciences

147 publications, 776 citations, 18 reviews

h-index: 14

Samara State Medical University

Symbiosis International University

Research interests

Marketing

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Pazukhina E. et al. Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) // BMC Medicine. 2022. Vol. 20. No. 1. 244

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@article{2022_Pazukhina,

author = {Ekaterina Pazukhina and Margarita Andreeva and Ekaterina Spiridonova and Polina Bobkova and Anastasia Shikhaleva and Yasmin El Taravi and Mikhail Rumyantsev and Aysylu Gamirova and Anastasiia Bairashevskaia and Polina Petrova and Dina Baimukhambetova and Maria Pikuza and Elina Abdeeva and Yulia Filippova and Salima Deunezhewa and Nikita Nekliudov and Polina Bugaeva and Nikolay Bulanov and Sergey Avdeev and Valentina Kapustina and Alla Guekht and Audrey DunnGalvin and Pasquale Comberiati and Diego G. Peroni and Christian Apfelbacher and Jon Genuneit and Luis Felipe Reyes and Caroline L H Brackel and Victor Fomin and Andrey A. Svistunov and Peter Timashev and Lyudmila Mazankova and Alexandra Miroshina and Elmira Samitova and Svetlana Borzakova and Elena Bondarenko and Anatoliy A Korsunskiy and Gail Carson and Louise Sigfrid and Janet T Scott and Matthew Greenhawt and Danilo Buonsenso and Malcolm G Semple and John O. Warner and Piero Olliaro and Dale M. Needham and Petr Glybochko and Denis Butnaru and Ismail M Osmanov and Daniel Munblit and others},

title = {Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)},

journal = {BMC Medicine},

year = {2022},

volume = {20},

publisher = {Springer Nature},

month = {jul},

url = {https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02448-4},

number = {1},

pages = {244},

doi = {10.1186/s12916-022-02448-4}

}

Publisher

Springer Nature

Journal

BMC Medicine

scimago Q1

wos Q1

SJR

2.846

CiteScore

11.3

Impact factor

8.3

ISSN

17417015 (Print, Electronic)

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