Open Access

Critical Care, volume 24, issue 1, publication number 312

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

Ekaterina A. Chernevskaya ¹

Natalia Beloborodova ¹

Natalia Klimenko ^{2, 3}

Alisa Pautova ¹

Dmitrii Shilkin ⁴

Vitaliy Gusarov ⁴

Alexander Tyakht ^{2, 3}

Hide authors affiliations Show authors affiliations: 4 affiliations

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |

Atlas Biomed Group - Knomics LLC, Moscow, Russia |

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia |

⁴

N. Pirogov National Medical Surgical Center, Moscow, Russia |

Publication type: Journal Article

Publication date: 2020-06-08

Springer Nature

Journal: Critical Care

Quartile SCImago

Quartile WOS

Impact factor: 15.1

ISSN: 13648535, 1466609X, 13648535, 18757081

DOI: 10.1186/s13054-020-03031-0

Copy DOI

Critical Care and Intensive Care Medicine

Abstract

High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversity in critical conditions. However, the landscape of gut microbial metabolites is still to be outlined, not to mention the interplay correlation between the metabolome and gut microbiome in critically ill patients. The aim of this study was to analyze the association between serum and fecal levels of AMM and compare them with the composition of gut microbiota in critically ill patients in the acute and chronic stages. In this prospective observational pilot study, we analyzed the temporal dynamics of the gut microbiome and the AMM spectrum across two distinct subgroups—acute critical ill (ACI) patients with nosocomial pneumonia and chronically critically ill (CCI) patients (9 subjects each group)—as well as performed comparison with 23 healthy volunteers. The AMM levels for each patient were measured using GC-MS in simultaneously taken serum and fecal samples (SFS). These parameters were compared with 16S rRNA fecal microbiome profiles. The observed proportions of bacterial taxa suggest a significant gut dysbiosis in the ACI and the CCI patients. Stronger imbalance in microbiome composition and dynamics observed in the ACI patients compared to the CCI ones resonates with a higher severity in the former group. The total levels of AMM in serum samples were higher for the ACI patients than for the CCI patients (3.7 (1.4–6.3) and 1.1 (1.0–1.6) μM, respectively; p = 0.0003). The qualitative composition of the SFS was also altered. We discovered significant associations between gut microbial taxa levels and metabolite concentrations in blood serum as well as in feces in each of the ACI and the CCI patients. Aromatic microbial metabolite profiles in the gut and the serum are interlinked and reflect a disruption of the gut microbial community in critically ill patients.

By date By citations

Top-30

Citations by journals

	1 2
Journal of Personalized Medicine	Journal of Personalized Medicine, 2, 7.41% Journal of Personalized Medicine 2 publications, 7.41%
Aging	Aging, 1, 3.7% Aging 1 publication, 3.7%
Metabolites	Metabolites, 1, 3.7% Metabolites 1 publication, 3.7%
Microorganisms	Microorganisms, 1, 3.7% Microorganisms 1 publication, 3.7%
Molecules	Molecules, 1, 3.7% Molecules 1 publication, 3.7%
Frontiers in Microbiology	Frontiers in Microbiology, 1, 3.7% Frontiers in Microbiology 1 publication, 3.7%
Animal Nutrition	Animal Nutrition, 1, 3.7% Animal Nutrition 1 publication, 3.7%
Poultry Science	Poultry Science, 1, 3.7% Poultry Science 1 publication, 3.7%
World Allergy Organization Journal	World Allergy Organization Journal, 1, 3.7% World Allergy Organization Journal 1 publication, 3.7%
Biomedicines	Biomedicines, 1, 3.7% Biomedicines 1 publication, 3.7%
Nutrition in Clinical Practice	Nutrition in Clinical Practice, 1, 3.7% Nutrition in Clinical Practice 1 publication, 3.7%
Science advances	Science advances, 1, 3.7% Science advances 1 publication, 3.7%
Bulletin of Russian State Medical University	Bulletin of Russian State Medical University, 1, 3.7% Bulletin of Russian State Medical University 1 publication, 3.7%
Almanac of Clinical Medicine	Almanac of Clinical Medicine, 1, 3.7% Almanac of Clinical Medicine 1 publication, 3.7%
Phytochemicals in Agriculture and Food [Working Title]	Phytochemicals in Agriculture and Food [Working Title], 1, 3.7% Phytochemicals in Agriculture and Food [Working Title] 1 publication, 3.7%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 1, 3.7% Computational and Structural Biotechnology Journal 1 publication, 3.7%
Nutrients	Nutrients, 1, 3.7% Nutrients 1 publication, 3.7%
BMC Microbiology	BMC Microbiology, 1, 3.7% BMC Microbiology 1 publication, 3.7%
Obshchaya Reanimatologiya	Obshchaya Reanimatologiya, 1, 3.7% Obshchaya Reanimatologiya 1 publication, 3.7%
BMC Medicine	BMC Medicine, 1, 3.7% BMC Medicine 1 publication, 3.7%
Journal of Analytical Chemistry	Journal of Analytical Chemistry, 1, 3.7% Journal of Analytical Chemistry 1 publication, 3.7%
Microbiome Research Reports	Microbiome Research Reports, 1, 3.7% Microbiome Research Reports 1 publication, 3.7%
Journal of Animal Science and Biotechnology	Journal of Animal Science and Biotechnology, 1, 3.7% Journal of Animal Science and Biotechnology 1 publication, 3.7%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 3.7% Russian Chemical Reviews 1 publication, 3.7%
	1 2

Citations by publishers

	1 2 3 4 5 6 7
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 25.93% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 25.93%
Springer Nature	Springer Nature, 4, 14.81% Springer Nature 4 publications, 14.81%
Elsevier	Elsevier, 2, 7.41% Elsevier 2 publications, 7.41%
Impact Journals	Impact Journals, 1, 3.7% Impact Journals 1 publication, 3.7%
Frontiers Media S.A.	Frontiers Media S.A., 1, 3.7% Frontiers Media S.A. 1 publication, 3.7%
KeAi Communications Co.	KeAi Communications Co., 1, 3.7% KeAi Communications Co. 1 publication, 3.7%
Wiley	Wiley, 1, 3.7% Wiley 1 publication, 3.7%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 3.7% American Association for the Advancement of Science (AAAS) 1 publication, 3.7%
Pirogov Russian National Research Medical University	Pirogov Russian National Research Medical University, 1, 3.7% Pirogov Russian National Research Medical University 1 publication, 3.7%
Moscow Regional Research and Clinical Institute (MONIKI)	Moscow Regional Research and Clinical Institute (MONIKI), 1, 3.7% Moscow Regional Research and Clinical Institute (MONIKI) 1 publication, 3.7%
IntechOpen	IntechOpen, 1, 3.7% IntechOpen 1 publication, 3.7%
V. A. Negovsky Research Institute of General Reanimatology	V. A. Negovsky Research Institute of General Reanimatology, 1, 3.7% V. A. Negovsky Research Institute of General Reanimatology 1 publication, 3.7%
Pleiades Publishing	Pleiades Publishing, 1, 3.7% Pleiades Publishing 1 publication, 3.7%
OAE Publishing Inc.	OAE Publishing Inc., 1, 3.7% OAE Publishing Inc. 1 publication, 3.7%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 3.7% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 3.7%
	1 2 3 4 5 6 7

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[4,6,4,9,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["14.81","22.22","14.81","33.33","14.81"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Personalized Medicine","Aging","Metabolites","Microorganisms","Molecules","Frontiers in Microbiology","Animal Nutrition","Poultry Science","World Allergy Organization Journal","Biomedicines","Nutrition in Clinical Practice","Science advances","Bulletin of Russian State Medical University","Almanac of Clinical Medicine","Phytochemicals in Agriculture and Food [Working Title]","Computational and Structural Biotechnology Journal","Nutrients","BMC Microbiology","Obshchaya Reanimatologiya","BMC Medicine","Journal of Analytical Chemistry","Microbiome Research Reports","Journal of Animal Science and Biotechnology","Russian Chemical Reviews"],"ids":[2479,780,17024,6197,1770,24403,5029,1290,14023,24421,24562,23003,20054,27265,42730,4268,3372,526,18491,20111,21398,64885,2881,23802],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/YbblL7g7LZxen4zAlAZD3Qq9UGfDJZMh3izylBaT_medium.webp","\/storage\/images\/resized\/xBIhD2cQS4PgCqdUerYTGy5aztom7uu0eM0dAXg1_medium.webp","","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/dIXgZVXZ9QdQ3x3VBZzswbdEzP8zjWjWy3CRMtLp_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/0oGA3odz6rRHYyWD8vQnHiPJ8KIaP1PtNoJm7RE1_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[7.41,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Elsevier","Impact Journals","Frontiers Media S.A.","KeAi Communications Co.","Wiley","American Association for the Advancement of Science (AAAS)","Pirogov Russian National Research Medical University","Moscow Regional Research and Clinical Institute (MONIKI)","IntechOpen","V. A. Negovsky Research Institute of General Reanimatology","Pleiades Publishing","OAE Publishing Inc.","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[202,8,17,342,208,326,11,189,5654,7261,8015,5301,101,7181,9422],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/YbblL7g7LZxen4zAlAZD3Qq9UGfDJZMh3izylBaT_medium.webp","\/storage\/images\/resized\/xBIhD2cQS4PgCqdUerYTGy5aztom7uu0eM0dAXg1_medium.webp","","\/storage\/images\/resized\/dIXgZVXZ9QdQ3x3VBZzswbdEzP8zjWjWy3CRMtLp_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/0oGA3odz6rRHYyWD8vQnHiPJ8KIaP1PtNoJm7RE1_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[7,4,2,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25.93,14.81,7.41,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[1,0,0,2,0],"percentage":["3.7","0","0","7.41","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0,0,0],"percentage":["0","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,4,1,1,0],"percentage":["3.7","14.81","3.7","3.7","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,1,3,4,3],"percentage":["3.7","3.7","11.11","14.81","11.11"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,1,0,2,1],"percentage":["3.7","3.7","0","7.41","3.7"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,1,0],"percentage":["0","0","0","3.7","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,0,0,0,0],"percentage":["3.7","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,4,1,1,0],"percentage":["3.7","14.81","3.7","3.7","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[0,0,2,4,3],"percentage":["0","0","7.41","14.81","11.11"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[2,2,1,3,1],"percentage":["7.41","7.41","3.7","11.11","3.7"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Chernevskaya E. A. et al. Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study // Critical Care. 2020. Vol. 24. No. 1. 312

GOST all authors (up to 50) Copy

Chernevskaya E. A., Beloborodova N., Klimenko N., Pautova A., Shilkin D., Gusarov V., Tyakht A. Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study // Critical Care. 2020. Vol. 24. No. 1. 312

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1186/s13054-020-03031-0

UR - https://doi.org/10.1186/s13054-020-03031-0

TI - Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

T2 - Critical Care

AU - Chernevskaya, Ekaterina A.

AU - Beloborodova, Natalia

AU - Klimenko, Natalia

AU - Pautova, Alisa

AU - Shilkin, Dmitrii

AU - Gusarov, Vitaliy

AU - Tyakht, Alexander

PY - 2020

DA - 2020/06/08 00:00:00

PB - Springer Nature

IS - 1

VL - 24

SN - 1364-8535

SN - 1466-609X

SN - 1364-8535

SN - 1875-7081

ER -

BibTex

Cite this

BibTex Copy

@article{2020_Chernevskaya,

author = {Ekaterina A. Chernevskaya and Natalia Beloborodova and Natalia Klimenko and Alisa Pautova and Dmitrii Shilkin and Vitaliy Gusarov and Alexander Tyakht},

title = {Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study},

journal = {Critical Care},

year = {2020},

volume = {24},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1186/s13054-020-03031-0},

number = {1},

doi = {10.1186/s13054-020-03031-0}

}

Found error?

Publisher

Springer Nature

Journal

Critical Care

Quartile SCImago

Quartile WOS

Impact factor

15.1

ISSN

13648535 (Print)
1466609X (Electronic)
13648535 (Electronic)
18757081 (Electronic)

Profiles

Shilkin, Dmitrii Nikolaevich