Open Access
Nano Convergence, volume 7, issue 1, publication number 17
Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis
Levada Kateryna
1
,
Pshenichnikov Stanislav
1
,
Rodionova Valeria
1
,
Nikitin Aleksey
2
,
Savchenko Alexander
2
,
Schetinin Igor
2
,
Zhukov Dmitry
2
,
Abakumov Maxim
2
,
Lunova Mariia
3, 4
,
Jirsa Milan
4
,
Smolková Barbora
3
,
Uzhytchak Mariia
3
,
Dejneka Alexandr
3
,
3
Institute of Physics of the Czech Academy of Sciences, Prague, Czech Republic
|
4
Institute for Clinical & Experimental Medicine (IKEM), Prague, Czech Republic
|
Publication type: Journal Article
Publication date: 2020-05-19
PubMed ID:
32424769
General Materials Science
General Engineering
Abstract
Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Both nanoparticles induced rather apoptosis than autophagy in HepG2. Contrary, IO-cubes and IO-clusters trigger distinct cell death signaling events in Alexander and Huh7 cells. Our data clarifies the mechanism by which cubic nanoparticles induce autophagic flux and the mechanism of subsequent toxicity. These findings imply that the cytotoxicity of ION-based contrast agents should be carefully considered, particularly in patients with liver diseases.
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1
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Levada K. et al. Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis // Nano Convergence. 2020. Vol. 7. No. 1. 17
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Levada K., Pshenichnikov S., Omelyanchik A., Rodionova V., Nikitin A., Savchenko A., Schetinin I., Zhukov D., Abakumov M., Majouga A., Lunova M., Jirsa M., Smolková B., Uzhytchak M., Dejneka A., Lunov O. Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis // Nano Convergence. 2020. Vol. 7. No. 1. 17
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TY - JOUR
DO - 10.1186/s40580-020-00228-5
UR - https://doi.org/10.1186%2Fs40580-020-00228-5
TI - Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis
T2 - Nano Convergence
AU - Pshenichnikov, Stanislav
AU - Omelyanchik, Alexander
AU - Rodionova, Valeria
AU - Nikitin, Aleksey
AU - Savchenko, Alexander
AU - Schetinin, Igor
AU - Zhukov, Dmitry
AU - Abakumov, Maxim
AU - Majouga, Alexander
AU - Lunova, Mariia
AU - Jirsa, Milan
AU - Smolková, Barbora
AU - Uzhytchak, Mariia
AU - Dejneka, Alexandr
AU - Lunov, Oleg
AU - Levada, Kateryna
PY - 2020
DA - 2020/05/19 00:00:00
PB - Springer Nature
IS - 1
VL - 7
PMID - 32424769
SN - 2196-5404
ER -
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@article{2020_Levada,
author = {Stanislav Pshenichnikov and Alexander Omelyanchik and Valeria Rodionova and Aleksey Nikitin and Alexander Savchenko and Igor Schetinin and Dmitry Zhukov and Maxim Abakumov and Alexander Majouga and Mariia Lunova and Milan Jirsa and Barbora Smolková and Mariia Uzhytchak and Alexandr Dejneka and Oleg Lunov and Kateryna Levada},
title = {Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis},
journal = {Nano Convergence},
year = {2020},
volume = {7},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1186%2Fs40580-020-00228-5},
number = {1},
doi = {10.1186/s40580-020-00228-5}
}