Open Access

Biomaterials Research, volume 25, issue 1, publication number 42

Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy

Do Hun Kim ^{1, 2}

Jin Myung Seo ^{1, 2}

Kyung Ju Shin ¹

SU-GEUN YANG ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon, South Korea |

Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon, South Korea |

Publication type: Journal Article

Publication date: 2021-11-25

Springer Nature

Journal: Biomaterials Research

Quartile SCImago

Quartile WOS

Impact factor: 11.3

ISSN: 20557124

DOI: 10.1186/s40824-021-00244-4

Copy DOI

Ceramics and Composites

Medicine (miscellaneous)

Biomaterials

Biomedical Engineering

Abstract

Aptamer has been called “chemical antibody” which displays the specific affinity to target molecules compared to that of antibodies and possesses several therapeutic advantages over antibodies in terms of size, accessibility to synthesis, and modification. Based on the attractive properties, aptamers have been interested in many directions and now are emerged as new target-designed cancer drug. Currently, new types of aptamers have been reported and attracted many scientists’ interesting. Due to simplicity of chemical modification and ready-made molecular engineering, scientists have developed newly designed aptamers conjugated with a wide range of therapeutics, aptamer-drug conjugates; ApDCs, from chemotherapy to phototherapy, gene therapy, and vaccines. ApDCs display synergistic therapeutic effects in cancer treatment. In this paper, we reviewed various kinds of ApDCs, i.e., ApDC nucleotide analogs, ApDC by drug intercalation, and ApDC by using chemical linker. Current data prove these ApDCs have sufficient potential to complete clinical development soon. Advanced technology of cancer drug delivery and combination treatment of cancers enables aptamer and conjugated drug (ApDCs) efficient means for targeted cancer treatment that reduces potential toxicity and increases therapeutic efficacy.

By date By citations

Top-30

Citations by journals

	1 2 3 4
Biosensors	Biosensors, 4, 8.51% Biosensors 4 publications, 8.51%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 2, 4.26% Frontiers in Cell and Developmental Biology 2 publications, 4.26%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 2, 4.26% International Journal of Biological Macromolecules 2 publications, 4.26%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 2, 4.26% Journal of Drug Delivery Science and Technology 2 publications, 4.26%
Biomaterials Research	Biomaterials Research, 2, 4.26% Biomaterials Research 2 publications, 4.26%
Comprehensive Analytical Chemistry	Comprehensive Analytical Chemistry, 2, 4.26% Comprehensive Analytical Chemistry 2 publications, 4.26%
Journal of Drug Targeting	Journal of Drug Targeting, 2, 4.26% Journal of Drug Targeting 2 publications, 4.26%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 2.13% Frontiers in Chemistry 1 publication, 2.13%
Bioengineering	Bioengineering, 1, 2.13% Bioengineering 1 publication, 2.13%
Molecules	Molecules, 1, 2.13% Molecules 1 publication, 2.13%
Drug Discovery Today	Drug Discovery Today, 1, 2.13% Drug Discovery Today 1 publication, 2.13%
Materials Today Bio	Materials Today Bio, 1, 2.13% Materials Today Bio 1 publication, 2.13%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 2.13% Biomedicine and Pharmacotherapy 1 publication, 2.13%
Biochimica et Biophysica Acta - Molecular Basis of Disease	Biochimica et Biophysica Acta - Molecular Basis of Disease, 1, 2.13% Biochimica et Biophysica Acta - Molecular Basis of Disease 1 publication, 2.13%
Archives of Pharmacal Research	Archives of Pharmacal Research, 1, 2.13% Archives of Pharmacal Research 1 publication, 2.13%
Biotechnology Journal	Biotechnology Journal, 1, 2.13% Biotechnology Journal 1 publication, 2.13%
OpenNano	OpenNano, 1, 2.13% OpenNano 1 publication, 2.13%
Nature Reviews Drug Discovery	Nature Reviews Drug Discovery, 1, 2.13% Nature Reviews Drug Discovery 1 publication, 2.13%
Journal of Controlled Release	Journal of Controlled Release, 1, 2.13% Journal of Controlled Release 1 publication, 2.13%
Molecular Therapy	Molecular Therapy, 1, 2.13% Molecular Therapy 1 publication, 2.13%
Cell Death Discovery	Cell Death Discovery, 1, 2.13% Cell Death Discovery 1 publication, 2.13%
Applied Research	Applied Research, 1, 2.13% Applied Research 1 publication, 2.13%
Advanced Biology	Advanced Biology, 1, 2.13% Advanced Biology 1 publication, 2.13%
Current HIV Research	Current HIV Research, 1, 2.13% Current HIV Research 1 publication, 2.13%
RNA Biology	RNA Biology, 1, 2.13% RNA Biology 1 publication, 2.13%
Methods in Molecular Biology	Methods in Molecular Biology, 1, 2.13% Methods in Molecular Biology 1 publication, 2.13%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.13% Russian Chemical Reviews 1 publication, 2.13%
Pharmaceutics	Pharmaceutics, 1, 2.13% Pharmaceutics 1 publication, 2.13%
Nucleic Acid Therapeutics	Nucleic Acid Therapeutics, 1, 2.13% Nucleic Acid Therapeutics 1 publication, 2.13%
	1 2 3 4

Citations by publishers

	2 4 6 8 10 12 14
Elsevier	Elsevier, 14, 29.79% Elsevier 14 publications, 29.79%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 14.89% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 14.89%
Springer Nature	Springer Nature, 6, 12.77% Springer Nature 6 publications, 12.77%
Wiley	Wiley, 4, 8.51% Wiley 4 publications, 8.51%
Frontiers Media S.A.	Frontiers Media S.A., 3, 6.38% Frontiers Media S.A. 3 publications, 6.38%
Taylor & Francis	Taylor & Francis, 3, 6.38% Taylor & Francis 3 publications, 6.38%
Bentham Science	Bentham Science, 2, 4.26% Bentham Science 2 publications, 4.26%
Pharmaceutical Society of Korea	Pharmaceutical Society of Korea, 1, 2.13% Pharmaceutical Society of Korea 1 publication, 2.13%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.13% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.13%
Mary Ann Liebert	Mary Ann Liebert, 1, 2.13% Mary Ann Liebert 1 publication, 2.13%
	2 4 6 8 10 12 14

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[6,18,23],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["12.77","38.3","48.94"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Biosensors","Frontiers in Cell and Developmental Biology","International Journal of Biological Macromolecules","Journal of Drug Delivery Science and Technology","Biomaterials Research","Comprehensive Analytical Chemistry","Journal of Drug Targeting","Frontiers in Chemistry","Bioengineering","Molecules","Drug Discovery Today","Materials Today Bio","Biomedicine and Pharmacotherapy","Biochimica et Biophysica Acta - Molecular Basis of Disease","Archives of Pharmacal Research","Biotechnology Journal","OpenNano","Nature Reviews Drug Discovery","Journal of Controlled Release","Molecular Therapy","Cell Death Discovery","Applied Research","Advanced Biology","Current HIV Research","RNA Biology","Methods in Molecular Biology","Russian Chemical Reviews","Pharmaceutics","Nucleic Acid Therapeutics"],"ids":[5233,12128,23035,17907,20055,5502,15730,6407,22376,1770,23042,2361,23951,15106,8807,12083,13539,14344,14351,2784,10757,28619,28748,10789,7613,3516,23802,4502,8743],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/orXcZtXpI7UpnWWqQEfW5ZNVoteL6CqvOi1ztUcD_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp"],"datasets":[{"label":"","data":[4,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[8.51,4.26,4.26,4.26,4.26,4.26,4.26,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13,2.13],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Wiley","Frontiers Media S.A.","Taylor & Francis","Bentham Science","Pharmaceutical Society of Korea","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii","Mary Ann Liebert"],"ids":[17,202,8,11,208,18,39,8825,9422,230],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/orXcZtXpI7UpnWWqQEfW5ZNVoteL6CqvOi1ztUcD_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp"],"datasets":[{"label":"","data":[14,7,6,4,3,3,2,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[29.79,14.89,12.77,8.51,6.38,6.38,4.26,2.13,2.13,2.13],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,1],"percentage":["0","0","2.13"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,1,2],"percentage":["0","2.13","4.26"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,0,1],"percentage":["2.13","0","2.13"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[5,11,17],"percentage":["10.64","23.4","36.17"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,6,2],"percentage":["0","12.77","4.26"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,1,1],"percentage":["0","2.13","2.13"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,1],"percentage":["0","0","2.13"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[3,0,5],"percentage":["6.38","0","10.64"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[3,10,12],"percentage":["6.38","21.28","25.53"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,7,4],"percentage":["0","14.89","8.51"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Kim D. H. et al. Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy // Biomaterials Research. 2021. Vol. 25. No. 1. 42

GOST all authors (up to 50) Copy

Kim D. H., Seo J. M., Shin K. J., YANG S. Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy // Biomaterials Research. 2021. Vol. 25. No. 1. 42

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1186/s40824-021-00244-4

UR - https://doi.org/10.1186/s40824-021-00244-4

TI - Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy

T2 - Biomaterials Research

AU - Kim, Do Hun

AU - Seo, Jin Myung

AU - Shin, Kyung Ju

AU - YANG, SU-GEUN

PY - 2021

DA - 2021/11/25 00:00:00

PB - Springer Nature

IS - 1

VL - 25

SN - 2055-7124

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Kim,

author = {Do Hun Kim and Jin Myung Seo and Kyung Ju Shin and SU-GEUN YANG},

title = {Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy},

journal = {Biomaterials Research},

year = {2021},

volume = {25},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1186/s40824-021-00244-4},

number = {1},

doi = {10.1186/s40824-021-00244-4}

}

Found error?

Publisher

Springer Nature

Journal

Biomaterials Research

Quartile SCImago

Quartile WOS

Impact factor

11.3

ISSN

20557124 (Electronic)