Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment
Publication type: Journal Article
Publication date: 2016-12-10
scimago Q1
wos Q1
SJR: 11.205
CiteScore: 38.9
Impact factor: 41.9
ISSN: 0732183X, 15277755
PubMed ID:
27903150
Cancer Research
Oncology
Abstract
In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer.
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Metrics
469
Total citations:
469
Citations from 2024:
158
(33.76%)
Cite this
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MLA
Cite this
GOST
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Onstad M. A., Schmandt R. E., Lu K. H. Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment // Journal of Clinical Oncology. 2016. Vol. 34. No. 35. pp. 4225-4230.
GOST all authors (up to 50)
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Onstad M. A., Schmandt R. E., Lu K. H. Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment // Journal of Clinical Oncology. 2016. Vol. 34. No. 35. pp. 4225-4230.
Cite this
RIS
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TY - JOUR
DO - 10.1200/jco.2016.69.4638
UR - https://doi.org/10.1200/jco.2016.69.4638
TI - Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment
T2 - Journal of Clinical Oncology
AU - Onstad, Michaela A.
AU - Schmandt, Rosemarie E.
AU - Lu, Karen H.
PY - 2016
DA - 2016/12/10
PB - American Society of Clinical Oncology (ASCO)
SP - 4225-4230
IS - 35
VL - 34
PMID - 27903150
SN - 0732-183X
SN - 1527-7755
ER -
Cite this
BibTex (up to 50 authors)
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@article{2016_Onstad,
author = {Michaela A. Onstad and Rosemarie E. Schmandt and Karen H. Lu},
title = {Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment},
journal = {Journal of Clinical Oncology},
year = {2016},
volume = {34},
publisher = {American Society of Clinical Oncology (ASCO)},
month = {dec},
url = {https://doi.org/10.1200/jco.2016.69.4638},
number = {35},
pages = {4225--4230},
doi = {10.1200/jco.2016.69.4638}
}
Cite this
MLA
Copy
Onstad, Michaela A., et al. “Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment.” Journal of Clinical Oncology, vol. 34, no. 35, Dec. 2016, pp. 4225-4230. https://doi.org/10.1200/jco.2016.69.4638.