volume 106 issue 1 pages 226-236

Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders

Dorina Ylli 1, 2
Leonard Wartofsky 1
Kenneth Burman 1
Publication typeJournal Article
Publication date2020-11-07
scimago Q1
wos Q1
SJR2.183
CiteScore11.5
Impact factor5.1
ISSN0021972X, 19457197
Biochemistry
Clinical Biochemistry
Endocrinology
Endocrinology, Diabetes and Metabolism
Biochemistry (medical)
Abstract

Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a structure similar to that of thyroid hormones. Deiodination of amiodarone releases large amounts of iodine that can impair thyroid function, causing either hypothyroidism or thyrotoxicosis in susceptible individuals reflecting ~20% of patients administered the drug. Not only the excess iodine, but also the amiodarone (or its metabolite, desethylamiodarone) itself may cause thyroid dysfunction by direct cytotoxicity on thyroid cells. We present an overview of the epidemiology and pathophysiology of amiodarone-induced thyroid disorders, with a focus on the various forms of clinical presentation and recommendations for personalized management of each form.

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GOST |
Cite this
GOST Copy
Ylli D. et al. Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders // Journal of Clinical Endocrinology and Metabolism. 2020. Vol. 106. No. 1. pp. 226-236.
GOST all authors (up to 50) Copy
Ylli D., Wartofsky L., Burman K. Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders // Journal of Clinical Endocrinology and Metabolism. 2020. Vol. 106. No. 1. pp. 226-236.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1210/clinem/dgaa686
UR - https://doi.org/10.1210/clinem/dgaa686
TI - Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders
T2 - Journal of Clinical Endocrinology and Metabolism
AU - Ylli, Dorina
AU - Wartofsky, Leonard
AU - Burman, Kenneth
PY - 2020
DA - 2020/11/07
PB - The Endocrine Society
SP - 226-236
IS - 1
VL - 106
PMID - 33159436
SN - 0021-972X
SN - 1945-7197
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Ylli,
author = {Dorina Ylli and Leonard Wartofsky and Kenneth Burman},
title = {Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders},
journal = {Journal of Clinical Endocrinology and Metabolism},
year = {2020},
volume = {106},
publisher = {The Endocrine Society},
month = {nov},
url = {https://doi.org/10.1210/clinem/dgaa686},
number = {1},
pages = {226--236},
doi = {10.1210/clinem/dgaa686}
}
MLA
Cite this
MLA Copy
Ylli, Dorina, et al. “Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders.” Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, Nov. 2020, pp. 226-236. https://doi.org/10.1210/clinem/dgaa686.