Open Access

Ovid Technologies (Wolters Kluwer Health)

Neurology

, volume 90 , issue 11 , pages e963-e970

Behavioral interventions as a treatment for epilepsy

Sheryl R. Haut ¹

Richard B. Lipton ²

Susannah Brock Cornes ³

Alok K Dwivedi ⁴

Sian Cotton ⁵

Jeffrey R. Strawn ⁶

Michael D. Privitera ⁷

Hide authors affiliations Show authors affiliations: 7 affiliations

From Montefiore-Einstein Epilepsy Center (S.R.H.) and Departments of Neurology (S.R.H., R.B.L.) and Epidemiology and Population Health (R.B.L.), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY |

University of California (S. Cornes), San Francisco, CA |

UNIVERSITY OF CALIFORNIA AT SAN FRANCISCO |

⁴

Paul L Foster School of Medicine

⁵

Integrative Medicine UC Cancer Institute

⁶

Psychiatry and Behavioral Neuroscience

⁷

University of Cincinnati** |

Publication type: Journal Article

Publication date: 2018-02-14

Ovid Technologies (Wolters Kluwer Health)

Neurology

scimago Q1

wos Q1

SJR: 2.401

CiteScore: 10.2

Impact factor: 8.5

ISSN: 00283878, 1526632X

DOI: 10.1212/WNL.0000000000005109

Copy DOI

PubMed ID: 29444968

Neurology (clinical)

Abstract

Objective

To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy.

Methods

Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment. Daily self-reported mood and stress ratings plus seizure counts were completed by participants using an electronic diary, and no medication adjustments were permitted. The primary outcome was percent reduction in seizure frequency per 28 days comparing baseline and treatment; secondary outcomes included stress reduction and stress–seizure interaction.

Results

In the 66 participants in the intention-to-treat analysis, seizure frequency was reduced from baseline in both treatment groups (PMR: 29%, p < 0.05; focused attention: 25%, p < 0.05). PMR and focused attention did not differ in seizure reduction (p = 0.38), although PMR was associated with stress reduction relative to focused attention (p < 0.05). Daily stress was not a predictor of seizures.

Conclusions

Both PMR and the focused-attention groups showed reduced seizure frequency compared to baseline in participants with medication-resistant focal seizures, although the 2 treatments did not differ. PMR was more effective than focused attention in reducing self-reported stress.

ClinicalTrials.gov identifier

NCT01444183.

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Cite this

GOST |

Cite this

GOST Copy

Haut S. R. et al. Behavioral interventions as a treatment for epilepsy // Neurology. 2018. Vol. 90. No. 11. p. e963-e970.

GOST all authors (up to 50) Copy

Haut S. R., Lipton R. B., Cornes S. B., Dwivedi A. K., Cotton S., Strawn J. R., Privitera M. D. Behavioral interventions as a treatment for epilepsy // Neurology. 2018. Vol. 90. No. 11. p. e963-e970.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1212/WNL.0000000000005109

UR - https://doi.org/10.1212/WNL.0000000000005109

TI - Behavioral interventions as a treatment for epilepsy

T2 - Neurology

AU - Haut, Sheryl R.

AU - Lipton, Richard B.

AU - Cornes, Susannah Brock

AU - Dwivedi, Alok K

AU - Cotton, Sian

AU - Strawn, Jeffrey R.

AU - Privitera, Michael D.

PY - 2018

DA - 2018/02/14

PB - Ovid Technologies (Wolters Kluwer Health)

SP - e963-e970

IS - 11

VL - 90

PMID - 29444968

SN - 0028-3878

SN - 1526-632X

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Haut,

author = {Sheryl R. Haut and Richard B. Lipton and Susannah Brock Cornes and Alok K Dwivedi and Sian Cotton and Jeffrey R. Strawn and Michael D. Privitera},

title = {Behavioral interventions as a treatment for epilepsy},

journal = {Neurology},

year = {2018},

volume = {90},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

month = {feb},

url = {https://doi.org/10.1212/WNL.0000000000005109},

number = {11},

pages = {e963--e970},

doi = {10.1212/WNL.0000000000005109}

}

MLA

Cite this

MLA Copy

Haut, Sheryl R., et al. “Behavioral interventions as a treatment for epilepsy.” Neurology, vol. 90, no. 11, Feb. 2018, pp. e963-e970. https://doi.org/10.1212/WNL.0000000000005109.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Journal

Neurology

scimago Q1

wos Q1

SJR

2.401

CiteScore

10.2

Impact factor

8.5

ISSN

00283878 (Print)

1526632X (Electronic)