Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition
Тип публикации: Journal Article
Дата публикации: 1996-08-01
scimago Q2
wos Q2
БС1
SJR: 0.678
CiteScore: 7
Impact factor: 3.8
ISSN: 00092673, 13480634
General Chemistry
Краткое описание
Two different classes of water-soluble fullerene derivatives, detergent-type and sphere-type, were synthesized. The derivatives were evaluated for their biological activities including cytotoxicity, DNA cleavage, and inhibition of HIV-protease and other enzymes. Both classes of compounds display generally similar behavior except for their cytotoxicity spectra against several cell lines. The fullerene derivatives bearing N-methylpyrrole were found to be photo-inactive with respect to DNA cleaving activity and cytotoxicity. A study on the kinetics for the inhibition of HIV-protease with detergent type derivative revealed that the compound is a potent fullerene-based HIV protease inhibitor, inhibiting the enzyme activity in a reversible and competitive manner with a Ki value of 0.32 μM.
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ГОСТ
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Nakamura E. et al. Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition // Bulletin of the Chemical Society of Japan. 1996. Vol. 69. No. 8. pp. 2143-2151.
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Nakamura E., Tokuyama H., Yamago S., Shiraki, T., SUGIURA Y. Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition // Bulletin of the Chemical Society of Japan. 1996. Vol. 69. No. 8. pp. 2143-2151.
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TY - JOUR
DO - 10.1246/bcsj.69.2143
UR - https://doi.org/10.1246/bcsj.69.2143
TI - Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition
T2 - Bulletin of the Chemical Society of Japan
AU - Nakamura, Eiichi
AU - Tokuyama, Hidetoshi
AU - Yamago, S.
AU - Shiraki,, Takashi
AU - SUGIURA, Yukio
PY - 1996
DA - 1996/08/01
PB - Oxford University Press
SP - 2143-2151
IS - 8
VL - 69
SN - 0009-2673
SN - 1348-0634
ER -
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@article{1996_Nakamura,
author = {Eiichi Nakamura and Hidetoshi Tokuyama and S. Yamago and Takashi Shiraki, and Yukio SUGIURA},
title = {Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition},
journal = {Bulletin of the Chemical Society of Japan},
year = {1996},
volume = {69},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1246/bcsj.69.2143},
number = {8},
pages = {2143--2151},
doi = {10.1246/bcsj.69.2143}
}
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MLA
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Nakamura, Eiichi, et al. “Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition.” Bulletin of the Chemical Society of Japan, vol. 69, no. 8, Aug. 1996, pp. 2143-2151. https://doi.org/10.1246/bcsj.69.2143.