Chemical and Pharmaceutical Bulletin, volume 21, issue 9, pages 1927-1937

Chemistry of Diborane and Sodium Borohydride. X. The Reduction of 2-or 4-Substituted Pyridines and Quinolines, and 1-or 3-Substituted Isoquinolines with Sodium Borohydride

Publication type: Journal Article
Publication date: 2011-12-08
scimago Q3
SJR: 0.358
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00092363, 13475223
General Chemistry
Drug Discovery
General Medicine
Abstract
The reaction of 2-or 4-substituted pyridines and quinolines and 1-or 3-substituted isoquinolines with sodium borohydride was examined. The substituent groups which are usually resistant to reduction with sodium borohydride were reducible through the electronic influence of the heteromatic ring. The solvent effects on the reduction with sodium borohydride were also examined.
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