Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents
1
Lead Discovery Research Laboratories, Sankyo Co., Ltd.
|
2
Biomedical Research Laboratories, Sankyo Co., Ltd.
Publication type: Journal Article
Publication date: 2005-06-01
scimago Q3
wos Q3
SJR: 0.349
CiteScore: 2.7
Impact factor: 1.3
ISSN: 00092363, 13475223
PubMed ID:
15930774
General Chemistry
Drug Discovery
General Medicine
Abstract
For the construction of new combinatorial libraries, a lead compound was created by replacing the core structure of a hit compound discovered by screening for cytotoxic agents against a tumorigenic cell line. The newly designed compound maintained biological activity and allowed alternative library construction for antitumor drugs.
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Total citations:
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Citations from 2024:
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MLA
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GOST
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Hayakawa I. et al. Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents // Chemical and Pharmaceutical Bulletin. 2005. Vol. 53. No. 6. pp. 638-640.
GOST all authors (up to 50)
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Hayakawa I., Shioya R., Agatsuma T., Sugano Y. Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents // Chemical and Pharmaceutical Bulletin. 2005. Vol. 53. No. 6. pp. 638-640.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1248/cpb.53.638
UR - https://doi.org/10.1248/cpb.53.638
TI - Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents
T2 - Chemical and Pharmaceutical Bulletin
AU - Hayakawa, Ichiro
AU - Shioya, Rieko
AU - Agatsuma, Toshinori
AU - Sugano, Yuichi
PY - 2005
DA - 2005/06/01
PB - Pharmaceutical Society of Japan
SP - 638-640
IS - 6
VL - 53
PMID - 15930774
SN - 0009-2363
SN - 1347-5223
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Hayakawa,
author = {Ichiro Hayakawa and Rieko Shioya and Toshinori Agatsuma and Yuichi Sugano},
title = {Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents},
journal = {Chemical and Pharmaceutical Bulletin},
year = {2005},
volume = {53},
publisher = {Pharmaceutical Society of Japan},
month = {jun},
url = {https://doi.org/10.1248/cpb.53.638},
number = {6},
pages = {638--640},
doi = {10.1248/cpb.53.638}
}
Cite this
MLA
Copy
Hayakawa, Ichiro, et al. “Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents.” Chemical and Pharmaceutical Bulletin, vol. 53, no. 6, Jun. 2005, pp. 638-640. https://doi.org/10.1248/cpb.53.638.