Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects
Publication type: Journal Article
Publication date: 2006-05-01
scimago Q3
wos Q3
SJR: 0.349
CiteScore: 2.7
Impact factor: 1.3
ISSN: 00092363, 13475223
PubMed ID:
16651781
General Chemistry
Drug Discovery
General Medicine
Abstract
A new cyclic diarylheptanoid, acerogenin M (1), has been isolated along with nine known diarylheptanoids, 2-10, and two known phenolic compounds, 11 and 12, from a MeOH extract of the stem bark of Acer nikoense MAXIM. (Aceraceae). The structure of 1 was determined on the basis of a spectroscopic method. Upon evaluation of the inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice of nine of the compounds (2-6, 8, 10-12), six (2, 4-6, 8, 10) showed a marked anti-inflammatory effect with a 50% inhibitory dose (ID(50)) of 0.26-0.81 mg per ear. In addition, upon an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, all exhibited moderate inhibitory effects against EBV-EA induction (IC(50) values of 356-534 mol ratio/32 pmol TPA).
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Total citations:
38
Citations from 2024:
1
(2.63%)
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Akihisa T. et al. Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects // Chemical and Pharmaceutical Bulletin. 2006. Vol. 54. No. 5. pp. 735-739.
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Akihisa T., Taguchi Y., Yasukawa K., Tokuda H., AKAZAWA H., Suzuki T., Kimura Y. Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects // Chemical and Pharmaceutical Bulletin. 2006. Vol. 54. No. 5. pp. 735-739.
Cite this
RIS
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TY - JOUR
DO - 10.1248/cpb.54.735
UR - https://doi.org/10.1248/cpb.54.735
TI - Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects
T2 - Chemical and Pharmaceutical Bulletin
AU - Akihisa, Toshihiro
AU - Taguchi, Yosuke
AU - Yasukawa, Ken
AU - Tokuda, Harukuni
AU - AKAZAWA, HIROYUKI
AU - Suzuki, Takashi
AU - Kimura, Yumiko
PY - 2006
DA - 2006/05/01
PB - Pharmaceutical Society of Japan
SP - 735-739
IS - 5
VL - 54
PMID - 16651781
SN - 0009-2363
SN - 1347-5223
ER -
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@article{2006_Akihisa,
author = {Toshihiro Akihisa and Yosuke Taguchi and Ken Yasukawa and Harukuni Tokuda and HIROYUKI AKAZAWA and Takashi Suzuki and Yumiko Kimura},
title = {Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects},
journal = {Chemical and Pharmaceutical Bulletin},
year = {2006},
volume = {54},
publisher = {Pharmaceutical Society of Japan},
month = {may},
url = {https://doi.org/10.1248/cpb.54.735},
number = {5},
pages = {735--739},
doi = {10.1248/cpb.54.735}
}
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MLA
Copy
Akihisa, Toshihiro, et al. “Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects.” Chemical and Pharmaceutical Bulletin, vol. 54, no. 5, May. 2006, pp. 735-739. https://doi.org/10.1248/cpb.54.735.