Chemical and Pharmaceutical Bulletin

, том 32 , издание 7 , страницы 2522-2529

Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs.

Тип публикации: Journal Article

Дата публикации: 2011-12-08

Pharmaceutical Society of Japan

Chemical and Pharmaceutical Bulletin

SCImago Q3

WOS Q3

БС2

SJR: 0.318

CiteScore: 2.7

Impact factor: 1.3

ISSN: 00092363, 13475223

DOI: 10.1248/cpb.32.2522

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PubMed ID: 6499080

General Chemistry

Drug Discovery

General Medicine

Краткое описание

5-Methyl-(4a), 7-methyl-(4b), and 8-methyl-5, 6, 7, 8-tetrahydro-1, 6-naphthyridine (4c) were synthesized by chemical modification of pyridine derivatives. On the other hand, the synthesis of the compounds (20b, c) having a methyl group in the aromatic ring of 5, 6, 7, 8-tetrahydro-1, 6-naphthyridine was accomplished by the condensation of 1-benzyl-4-piperidinone with the corresponding 3-amino-enones followed by debenzylation. The pathway of the condensation is briefly discussed.

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SHIOZAWA A. et al. Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs. // Chemical and Pharmaceutical Bulletin. 2011. Vol. 32. No. 7. pp. 2522-2529.

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SHIOZAWA A., ICHIKAWA Y., KOMURO C., KURASHIGE S., MIYAZAKI H., Yamanaka H., SAKAMOTO T. Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs. // Chemical and Pharmaceutical Bulletin. 2011. Vol. 32. No. 7. pp. 2522-2529.

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TY - JOUR

DO - 10.1248/cpb.32.2522

UR - https://doi.org/10.1248/cpb.32.2522

TI - Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs.

T2 - Chemical and Pharmaceutical Bulletin

AU - SHIOZAWA, Akira

AU - ICHIKAWA, YUHICHIRO

AU - KOMURO, CHIKARA

AU - KURASHIGE, SHUJI

AU - MIYAZAKI, Hiroshi

AU - Yamanaka, Hiroshi

AU - SAKAMOTO, Takao

PY - 2011

DA - 2011/12/08

PB - Pharmaceutical Society of Japan

SP - 2522-2529

IS - 7

VL - 32

PMID - 6499080

SN - 0009-2363

SN - 1347-5223

ER -

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@article{2011_SHIOZAWA,

author = {Akira SHIOZAWA and YUHICHIRO ICHIKAWA and CHIKARA KOMURO and SHUJI KURASHIGE and Hiroshi MIYAZAKI and Hiroshi Yamanaka and Takao SAKAMOTO},

title = {Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs.},

journal = {Chemical and Pharmaceutical Bulletin},

year = {2011},

volume = {32},

publisher = {Pharmaceutical Society of Japan},

month = {dec},

url = {https://doi.org/10.1248/cpb.32.2522},

number = {7},

pages = {2522--2529},

doi = {10.1248/cpb.32.2522}

}

MLA

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MLA Скопировать

SHIOZAWA, Akira, et al. “Antivertigo agents. III. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridine methyl homologs..” Chemical and Pharmaceutical Bulletin, vol. 32, no. 7, Dec. 2011, pp. 2522-2529. https://doi.org/10.1248/cpb.32.2522.

Издатель

Pharmaceutical Society of Japan

Журнал

Chemical and Pharmaceutical Bulletin

SCImago Q3

WOS Q3

БС2

SJR

0.318

CiteScore

2.7

Impact factor

1.3

ISSN

00092363 (Print)

13475223 (Electronic)

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