Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP).
Тип публикации: Journal Article
Дата публикации: 2011-12-08
SCImago Q3
WOS Q3
БС2
SJR: 0.318
CiteScore: 2.4
Impact factor: 1.5
ISSN: 00092363, 13475223
PubMed ID:
3486723
General Chemistry
Drug Discovery
General Medicine
Краткое описание
The heptatriacontapeptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP) was synthesized by assembling seven peptide fragments in solution, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid and subsequent air-oxidation to establish the disulfide bridge. The S-1-adamantyl group of the Cys residue was removed in two ways; one was by treatment with the above acid, together with the other protecting groups employed, and the other was selectively by treatment with(CF3COO)3Tl. The synthetic peptide produced a significant increase of cyclic adenosine monophosphate in calvaria and brain of a newborn rat, but suppressed 45Ca-release from mouse calvaria stimulated by parathyroid hormone.
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Fujii N. et al. Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP). // Chemical and Pharmaceutical Bulletin. 2011. Vol. 34. No. 2. pp. 613-620.
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Fujii N., Otaka A., FUNAKOSHI S., Nomizu M., Akaji K., Yajima H., Yamamoto I., TORIZUKA K., KITAGAWA K., AKITA T., ANDO K., Kawamoto T., Shimonishi Y., TAKAO T. Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP). // Chemical and Pharmaceutical Bulletin. 2011. Vol. 34. No. 2. pp. 613-620.
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TY - JOUR
DO - 10.1248/cpb.34.613
UR - https://doi.org/10.1248/cpb.34.613
TI - Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP).
T2 - Chemical and Pharmaceutical Bulletin
AU - Fujii, N.
AU - Otaka, Akira
AU - FUNAKOSHI, Susumu
AU - Nomizu, Motoyoshi
AU - Akaji, Kenichi
AU - Yajima, Haruaki
AU - Yamamoto, Itsuo
AU - TORIZUKA, Kanji
AU - KITAGAWA, Kouki
AU - AKITA, Tadashi
AU - ANDO, KENSHI
AU - Kawamoto, Tatsuhiko
AU - Shimonishi, Yasutsugu
AU - TAKAO, Toshifumi
PY - 2011
DA - 2011/12/08
PB - Pharmaceutical Society of Japan
SP - 613-620
IS - 2
VL - 34
PMID - 3486723
SN - 0009-2363
SN - 1347-5223
ER -
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@article{2011_Fujii,
author = {N. Fujii and Akira Otaka and Susumu FUNAKOSHI and Motoyoshi Nomizu and Kenichi Akaji and Haruaki Yajima and Itsuo Yamamoto and Kanji TORIZUKA and Kouki KITAGAWA and Tadashi AKITA and KENSHI ANDO and Tatsuhiko Kawamoto and Yasutsugu Shimonishi and Toshifumi TAKAO},
title = {Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP).},
journal = {Chemical and Pharmaceutical Bulletin},
year = {2011},
volume = {34},
publisher = {Pharmaceutical Society of Japan},
month = {dec},
url = {https://doi.org/10.1248/cpb.34.613},
number = {2},
pages = {613--620},
doi = {10.1248/cpb.34.613}
}
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Fujii, N., et al. “Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP)..” Chemical and Pharmaceutical Bulletin, vol. 34, no. 2, Dec. 2011, pp. 613-620. https://doi.org/10.1248/cpb.34.613.
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