1,4-Naphthoquinones: Some Biological Properties and Application
1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science
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Publication type: Journal Article
Publication date: 2019-12-31
scimago Q3
wos Q3
SJR: 0.349
CiteScore: 2.7
Impact factor: 1.3
ISSN: 00092363, 13475223
PubMed ID:
31902901
General Chemistry
Drug Discovery
General Medicine
Abstract
Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, anti-ischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.
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139
Total citations:
139
Citations from 2025:
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(20.87%)
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Aminin D., Polonik S. 1,4-Naphthoquinones: Some Biological Properties and Application // Chemical and Pharmaceutical Bulletin. 2019. Vol. 68. No. 1. pp. 46-57.
GOST all authors (up to 50)
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Aminin D., Polonik S. 1,4-Naphthoquinones: Some Biological Properties and Application // Chemical and Pharmaceutical Bulletin. 2019. Vol. 68. No. 1. pp. 46-57.
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TY - JOUR
DO - 10.1248/cpb.c19-00911
UR - https://doi.org/10.1248/cpb.c19-00911
TI - 1,4-Naphthoquinones: Some Biological Properties and Application
T2 - Chemical and Pharmaceutical Bulletin
AU - Aminin, Dmitry
AU - Polonik, Sergey
PY - 2019
DA - 2019/12/31
PB - Pharmaceutical Society of Japan
SP - 46-57
IS - 1
VL - 68
PMID - 31902901
SN - 0009-2363
SN - 1347-5223
ER -
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BibTex (up to 50 authors)
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@article{2019_Aminin,
author = {Dmitry Aminin and Sergey Polonik},
title = {1,4-Naphthoquinones: Some Biological Properties and Application},
journal = {Chemical and Pharmaceutical Bulletin},
year = {2019},
volume = {68},
publisher = {Pharmaceutical Society of Japan},
month = {dec},
url = {https://doi.org/10.1248/cpb.c19-00911},
number = {1},
pages = {46--57},
doi = {10.1248/cpb.c19-00911}
}
Cite this
MLA
Copy
Aminin, Dmitry, et al. “1,4-Naphthoquinones: Some Biological Properties and Application.” Chemical and Pharmaceutical Bulletin, vol. 68, no. 1, Dec. 2019, pp. 46-57. https://doi.org/10.1248/cpb.c19-00911.