Open Access

F1000Research, volume 6, pages 172

New insights into bacterial type II polyketide biosynthesis

Zhang Zhuan ¹

Pan Hai-Xue ¹

Tang Gongli ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai,China |

Publication type: Journal Article

Publication date: 2017-02-21

F1000 Research

Journal: F1000Research

Quartile SCImago

Quartile WOS

—

Impact factor: —

ISSN: 20461402

DOI: 10.12688/f1000research.10466.1

Copy DOI

PubMed ID: 28299197

General Biochemistry, Genetics and Molecular Biology

General Medicine

General Immunology and Microbiology

General Pharmacology, Toxicology and Pharmaceutics

Abstract

Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984–1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013–2016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included.

By date By citations

Citations by journals

	1 2 3 4
Journal of Natural Products	Journal of Natural Products, 4, 7.02% Journal of Natural Products 4 publications, 7.02%
Nature Chemical Biology	Nature Chemical Biology, 2, 3.51% Nature Chemical Biology 2 publications, 3.51%
Microorganisms	Microorganisms, 2, 3.51% Microorganisms 2 publications, 3.51%
Frontiers in Chemistry	Frontiers in Chemistry, 2, 3.51% Frontiers in Chemistry 2 publications, 3.51%
Frontiers in Microbiology	Frontiers in Microbiology, 2, 3.51% Frontiers in Microbiology 2 publications, 3.51%
Microbial Cell Factories	Microbial Cell Factories, 2, 3.51% Microbial Cell Factories 2 publications, 3.51%
Biotechnology Advances	Biotechnology Advances, 2, 3.51% Biotechnology Advances 2 publications, 3.51%
Angewandte Chemie	Angewandte Chemie, 2, 3.51% Angewandte Chemie 2 publications, 3.51%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 2, 3.51% Angewandte Chemie - International Edition 2 publications, 3.51%
JACS Au	JACS Au, 2, 3.51% JACS Au 2 publications, 3.51%
Microbiology spectrum	Microbiology spectrum, 1, 1.75% Microbiology spectrum 1 publication, 1.75%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 1.75% Frontiers in Cell and Developmental Biology 1 publication, 1.75%
Antibiotics	Antibiotics, 1, 1.75% Antibiotics 1 publication, 1.75%
International Journal of Environmental Research and Public Health	International Journal of Environmental Research and Public Health, 1, 1.75% International Journal of Environmental Research and Public Health 1 publication, 1.75%
Journal of Fungi	Journal of Fungi, 1, 1.75% Journal of Fungi 1 publication, 1.75%
Current Microbiology	Current Microbiology, 1, 1.75% Current Microbiology 1 publication, 1.75%
Nature Reviews Chemistry	Nature Reviews Chemistry, 1, 1.75% Nature Reviews Chemistry 1 publication, 1.75%
Probiotics and Antimicrobial Proteins	Probiotics and Antimicrobial Proteins, 1, 1.75% Probiotics and Antimicrobial Proteins 1 publication, 1.75%
Indian Journal of Microbiology	Indian Journal of Microbiology, 1, 1.75% Indian Journal of Microbiology 1 publication, 1.75%
PLoS ONE	PLoS ONE, 1, 1.75% PLoS ONE 1 publication, 1.75%
International Journal of Biochemistry and Cell Biology	International Journal of Biochemistry and Cell Biology, 1, 1.75% International Journal of Biochemistry and Cell Biology 1 publication, 1.75%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 1, 1.75% Bioorganic and Medicinal Chemistry 1 publication, 1.75%
Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 1.75% Journal of Biological Chemistry 1 publication, 1.75%
Synthetic and Systems Biotechnology	Synthetic and Systems Biotechnology, 1, 1.75% Synthetic and Systems Biotechnology 1 publication, 1.75%
FEBS Letters	FEBS Letters, 1, 1.75% FEBS Letters 1 publication, 1.75%
ACS Chemical Biology	ACS Chemical Biology, 1, 1.75% ACS Chemical Biology 1 publication, 1.75%
ACS Catalysis	ACS Catalysis, 1, 1.75% ACS Catalysis 1 publication, 1.75%
Biochemistry	Biochemistry, 1, 1.75% Biochemistry 1 publication, 1.75%
Journal of Organic Chemistry	Journal of Organic Chemistry, 1, 1.75% Journal of Organic Chemistry 1 publication, 1.75%
	1 2 3 4

Citations by publishers

	2 4 6 8 10 12
American Chemical Society (ACS)	American Chemical Society (ACS), 11, 19.3% American Chemical Society (ACS) 11 publications, 19.3%
Springer Nature	Springer Nature, 9, 15.79% Springer Nature 9 publications, 15.79%
Frontiers Media S.A.	Frontiers Media S.A., 5, 8.77% Frontiers Media S.A. 5 publications, 8.77%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 8.77% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 8.77%
Wiley	Wiley, 5, 8.77% Wiley 5 publications, 8.77%
Elsevier	Elsevier, 4, 7.02% Elsevier 4 publications, 7.02%
American Society for Microbiology	American Society for Microbiology, 3, 5.26% American Society for Microbiology 3 publications, 5.26%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.75% Public Library of Science (PLoS) 1 publication, 1.75%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.75% American Society for Biochemistry and Molecular Biology 1 publication, 1.75%
KeAi Communications Co.	KeAi Communications Co., 1, 1.75% KeAi Communications Co. 1 publication, 1.75%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 1.75% Royal Society of Chemistry (RSC) 1 publication, 1.75%
Taylor & Francis	Taylor & Francis, 1, 1.75% Taylor & Francis 1 publication, 1.75%
	2 4 6 8 10 12

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0],"imageUrls":["","","","","","",""],"datasets":[{"label":"Citations number","data":[7,8,13,9,9,9,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["12.28","14.04","22.81","15.79","15.79","15.79","3.51"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Natural Products","Nature Chemical Biology","Microorganisms","Frontiers in Chemistry","Frontiers in Microbiology","Microbial Cell Factories","Biotechnology Advances","Angewandte Chemie","Angewandte Chemie - International Edition","JACS Au","Microbiology spectrum","Frontiers in Cell and Developmental Biology","Antibiotics","International Journal of Environmental Research and Public Health","Journal of Fungi","Current Microbiology","Nature Reviews Chemistry","Probiotics and Antimicrobial Proteins","Indian Journal of Microbiology","PLoS ONE","International Journal of Biochemistry and Cell Biology","Bioorganic and Medicinal Chemistry","Journal of Biological Chemistry","Synthetic and Systems Biotechnology","FEBS Letters","ACS Chemical Biology","ACS Catalysis","Biochemistry","Journal of Organic Chemistry"],"ids":[16163,17718,6197,6407,24403,23412,17421,25450,19215,26622,17855,12128,1488,1426,3021,21888,6657,8735,12516,24963,11801,1162,19451,5926,405,2045,4873,9964,8697],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[4,2,2,2,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[7.02,3.51,3.51,3.51,3.51,3.51,3.51,3.51,3.51,3.51,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75,1.75],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["American Chemical Society (ACS)","Springer Nature","Frontiers Media S.A.","Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","Elsevier","American Society for Microbiology","Public Library of Science (PLoS)","American Society for Biochemistry and Molecular Biology","KeAi Communications Co.","Royal Society of Chemistry (RSC)","Taylor & Francis"],"ids":[40,8,208,202,11,17,142,344,2090,326,123,18],"codes":[0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp"],"datasets":[{"label":"","data":[11,9,5,5,5,4,3,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[19.3,15.79,8.77,8.77,8.77,7.02,5.26,1.75,1.75,1.75,1.75,1.75],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Zhang Z., Pan H., Tang G. New insights into bacterial type II polyketide biosynthesis // F1000Research. 2017. Vol. 6. p. 172.

GOST all authors (up to 50) Copy

Zhang Z., Pan H., Tang G. New insights into bacterial type II polyketide biosynthesis // F1000Research. 2017. Vol. 6. p. 172.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.12688/f1000research.10466.1

UR - https://doi.org/10.12688%2Ff1000research.10466.1

TI - New insights into bacterial type II polyketide biosynthesis

T2 - F1000Research

AU - Zhang, Zhuan

AU - Pan, Hai-Xue

AU - Tang, Gongli

PY - 2017

DA - 2017/02/21 00:00:00

PB - F1000 Research

SP - 172

VL - 6

PMID - 28299197

SN - 2046-1402

ER -

BibTex

Cite this

BibTex Copy

@article{2017_Zhang,

author = {Zhuan Zhang and Hai-Xue Pan and Gongli Tang},

title = {New insights into bacterial type II polyketide biosynthesis},

journal = {F1000Research},

year = {2017},

volume = {6},

publisher = {F1000 Research},

month = {feb},

url = {https://doi.org/10.12688%2Ff1000research.10466.1},

pages = {172},

doi = {10.12688/f1000research.10466.1}

}

Found error?

Publisher

F1000 Research

Journal

F1000Research

Quartile SCImago

Quartile WOS

—

Impact factor

—

ISSN

20461402 (Electronic)