Open Access
Journal of Lipid and Atherosclerosis, volume 12, issue 3, pages 223-236
Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis
Publication type: Journal Article
Publication date: 2023-09-25
Journal:
Journal of Lipid and Atherosclerosis
Quartile SCImago
Q1
Quartile WOS
—
Impact factor: —
ISSN: 22872892, 22882561
PubMed ID:
37800111
Cardiology and Cardiovascular Medicine
Endocrinology, Diabetes and Metabolism
Internal Medicine
Abstract
The proteins of the Wnt family are involved in a variety of physiological processes by means of several canonical and noncanonical signaling pathways. Wnt signaling has been recently identified as a major player in atherogenesis. In this review, we summarize the existing knowledge on the influence of various components of the Wnt signaling pathways on the initiation and progression of atherosclerosis and associated conditions. We used the PubMed database to search for recent papers on the involvement of the Wnt pathways in atherosclerosis. We used the combination of “Wnt” and “atherosclerosis” keywords to find the initial papers, and chose papers published after 2018. In the first section of the paper, we describe the general mechanisms of the Wnt signaling pathways and their components. The next section is dedicated to existing studies assessing the implication of Wnt signaling elements in different atherogenic processes, such as cholesterol retention, endothelial dysfunction, vascular inflammation, and atherosclerotic calcification of the vessels. Lastly, various therapeutic strategies based on interference with the Wnt signaling pathways are considered. We also compare the efficacy and availability of the proposed treatment methods. Wnt signaling can be considered a potential target in the treatment and prevention of atherosclerosis. Therefore, in this review, we reviewed evidences showing that wnt signaling is an important signal for developing appropriate treatment strategies for atherosclerosis.
Citations by journals
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1
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Biomedicines
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Biomedicines
1 publication, 50%
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Frontiers in Cardiovascular Medicine
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Frontiers in Cardiovascular Medicine
1 publication, 50%
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1
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 50%
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1
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- Statistics recalculated weekly.
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Poznyak A. V. et al. Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis // Journal of Lipid and Atherosclerosis. 2023. Vol. 12. No. 3. p. 223-236.
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Poznyak A. V., Sukhorukov V. N., Popov M. А., Chegodaev Y. S., Postnov A., Orekhov A. N. Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis // Journal of Lipid and Atherosclerosis. 2023. Vol. 12. No. 3. p. 223-236.
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TY - JOUR
DO - 10.12997/JLA.2023.12.3.223
UR - https://doi.org/10.12997%2FJLA.2023.12.3.223
TI - Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis
T2 - Journal of Lipid and Atherosclerosis
AU - Poznyak, Anastasia V.
AU - Sukhorukov, Vasily N.
AU - Popov, M А
AU - Chegodaev, Yegor S.
AU - Postnov, A.
AU - Orekhov, Alexander N.
PY - 2023
DA - 2023/09/25 00:00:00
PB - Korean Society of Lipidology and Atherosclerosis
SP - 223-236
IS - 3
VL - 12
PMID - 37800111
SN - 2287-2892
SN - 2288-2561
ER -
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@article{2023_Poznyak,
author = {Anastasia V. Poznyak and Vasily N. Sukhorukov and M А Popov and Yegor S. Chegodaev and A. Postnov and Alexander N. Orekhov},
title = {Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis},
journal = {Journal of Lipid and Atherosclerosis},
year = {2023},
volume = {12},
publisher = {Korean Society of Lipidology and Atherosclerosis},
month = {sep},
url = {https://doi.org/10.12997%2FJLA.2023.12.3.223},
number = {3},
pages = {223--236},
doi = {10.12997/JLA.2023.12.3.223}
}
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MLA
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Poznyak, Anastasia V., et al. “Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis.” Journal of Lipid and Atherosclerosis, vol. 12, no. 3, Sep. 2023, pp. 223-236. https://doi.org/10.12997%2FJLA.2023.12.3.223.