Open Access
Biomedical Optics Express, volume 11, issue 3, pages 1477
Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations
Subochev Pavel
1
,
Smolina Ekaterina
1
,
Sergeeva Ekaterina
1
,
Kirillin Mikhail
1
,
Orlova Anna
1
,
Kurakina Daria
1
,
Emyanov Daniil
1
,
Razansky Daniel
2
Publication type: Journal Article
Publication date: 2020-02-20
Journal:
Biomedical Optics Express
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 21567085
PubMed ID:
32206423
Biotechnology
Atomic and Molecular Physics, and Optics
Abstract
Cerebrovascular imaging of rodents is one of the trending applications of optoacoustics aimed at studying brain activity and pathology. Imaging of deep brain structures is often hindered by sub-optimal arrangement of the light delivery and acoustic detection systems. In our work we revisit the physics behind opto-acoustic signal generation for theoretical evaluation of optimal laser wavelengths to perform cerebrovascular optoacoustic angiography of rodents beyond the penetration barriers imposed by light diffusion in highly scattering and absorbing brain tissues. A comprehensive model based on diffusion approximation was developed to simulate optoacoustic signal generation using optical and acoustic parameters closely mimicking a typical murine brain. The model revealed three characteristic wavelength ranges in the visible and near-infrared spectra optimally suited for imaging cerebral vasculature of different size and depth. The theoretical conclusions are confirmed by numerical simulations while in vivo imaging experiments further validated the ability to accurately resolve brain vasculature at depths ranging between 0.7 and 7 mm.
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1 publication, 7.69%
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1 publication, 7.69%
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1 publication, 7.69%
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Citations by publishers
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2
3
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Optical Society of America
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3 publications, 23.08%
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3 publications, 23.08%
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IOP Publishing
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IOP Publishing
2 publications, 15.38%
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Elsevier
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Elsevier
1 publication, 7.69%
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SPIE
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SPIE
1 publication, 7.69%
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Springer Nature
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Springer Nature
1 publication, 7.69%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 7.69%
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IEEE
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IEEE
1 publication, 7.69%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Subochev P. et al. Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations // Biomedical Optics Express. 2020. Vol. 11. No. 3. p. 1477.
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Subochev P., Smolina E., Sergeeva E., Kirillin M., Orlova A., Kurakina D., Emyanov D., Razansky D. Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations // Biomedical Optics Express. 2020. Vol. 11. No. 3. p. 1477.
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TY - JOUR
DO - 10.1364/boe.377670
UR - https://doi.org/10.1364%2Fboe.377670
TI - Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations
T2 - Biomedical Optics Express
AU - Subochev, Pavel
AU - Smolina, Ekaterina
AU - Sergeeva, Ekaterina
AU - Kirillin, Mikhail
AU - Orlova, Anna
AU - Kurakina, Daria
AU - Emyanov, Daniil
AU - Razansky, Daniel
PY - 2020
DA - 2020/02/20 00:00:00
PB - Optical Society of America
SP - 1477
IS - 3
VL - 11
PMID - 32206423
SN - 2156-7085
ER -
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@article{2020_Subochev,
author = {Pavel Subochev and Ekaterina Smolina and Ekaterina Sergeeva and Mikhail Kirillin and Anna Orlova and Daria Kurakina and Daniil Emyanov and Daniel Razansky},
title = {Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations},
journal = {Biomedical Optics Express},
year = {2020},
volume = {11},
publisher = {Optical Society of America},
month = {feb},
url = {https://doi.org/10.1364%2Fboe.377670},
number = {3},
pages = {1477},
doi = {10.1364/boe.377670}
}
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MLA
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Subochev, Pavel, et al. “Toward whole-brain in vivo optoacoustic angiography of rodents: modeling and experimental observations.” Biomedical Optics Express, vol. 11, no. 3, Feb. 2020, p. 1477. https://doi.org/10.1364%2Fboe.377670.