Open Access
Open access
volume 19 issue 12 pages e1011660

Dissolution of spiral wave’s core using cardiac optogenetics

Sayedeh Hussaini 1
Sarah L. Lädke 2
Johannes Schröder-Schetelig 1
Vishalini Venkatesan 2
Raúl A Quiñonez Uribe 1
Claudia Richter 1
Rupamanjari Majumder 1
Stefan Luther 1
Publication typeJournal Article
Publication date2023-12-07
scimago Q1
wos Q1
SJR1.503
CiteScore7.2
Impact factor3.6
ISSN1553734X, 15537358
Molecular Biology
Genetics
Computational Theory and Mathematics
Cellular and Molecular Neuroscience
Ecology, Evolution, Behavior and Systematics
Ecology
Modeling and Simulation
Abstract

Rotating spiral waves in the heart are associated with life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process called defibrillation, which forces electrical resynchronization of the heart tissue by delivering a single global high-voltage shock directly to the heart. This method leads to immediate termination of spiral waves. However, this may not be the only mechanism underlying successful defibrillation, as certain scenarios have also been reported, where the arrhythmia terminated slowly, over a finite period of time. Here, we investigate the slow termination dynamics of an arrhythmia in optogenetically modified murine cardiac tissue both in silico and ex vivo during global illumination at low light intensities. Optical imaging of an intact mouse heart during a ventricular arrhythmia shows slow termination of the arrhythmia, which is due to action potential prolongation observed during the last rotation of the wave. Our numerical studies show that when the core of a spiral is illuminated, it begins to expand, pushing the spiral arm towards the inexcitable boundary of the domain, leading to termination of the spiral wave. We believe that these fundamental findings lead to a better understanding of arrhythmia dynamics during slow termination, which in turn has implications for the improvement and development of new cardiac defibrillation techniques.

Found 
Found 

Top-30

Journals

1
2
Chaos, Solitons and Fractals
2 publications, 22.22%
Chaos
1 publication, 11.11%
JETP Letters
1 publication, 11.11%
Advanced Science
1 publication, 11.11%
Biomedicines
1 publication, 11.11%
Journal of Translational Medicine
1 publication, 11.11%
Neural Networks
1 publication, 11.11%
Physical Review E
1 publication, 11.11%
1
2

Publishers

1
2
3
Elsevier
3 publications, 33.33%
AIP Publishing
1 publication, 11.11%
Pleiades Publishing
1 publication, 11.11%
Wiley
1 publication, 11.11%
MDPI
1 publication, 11.11%
Springer Nature
1 publication, 11.11%
American Physical Society (APS)
1 publication, 11.11%
1
2
3
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
10
Share
Cite this
GOST |
Cite this
GOST Copy
Hussaini S. et al. Dissolution of spiral wave’s core using cardiac optogenetics // PLoS Computational Biology. 2023. Vol. 19. No. 12. p. e1011660.
GOST all authors (up to 50) Copy
Hussaini S., Lädke S. L., Schröder-Schetelig J., Venkatesan V., Quiñonez Uribe R. A., Richter C., Majumder R., Luther S. Dissolution of spiral wave’s core using cardiac optogenetics // PLoS Computational Biology. 2023. Vol. 19. No. 12. p. e1011660.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1371/journal.pcbi.1011660
UR - https://doi.org/10.1371/journal.pcbi.1011660
TI - Dissolution of spiral wave’s core using cardiac optogenetics
T2 - PLoS Computational Biology
AU - Hussaini, Sayedeh
AU - Lädke, Sarah L.
AU - Schröder-Schetelig, Johannes
AU - Venkatesan, Vishalini
AU - Quiñonez Uribe, Raúl A
AU - Richter, Claudia
AU - Majumder, Rupamanjari
AU - Luther, Stefan
PY - 2023
DA - 2023/12/07
PB - Public Library of Science (PLoS)
SP - e1011660
IS - 12
VL - 19
PMID - 38060618
SN - 1553-734X
SN - 1553-7358
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Hussaini,
author = {Sayedeh Hussaini and Sarah L. Lädke and Johannes Schröder-Schetelig and Vishalini Venkatesan and Raúl A Quiñonez Uribe and Claudia Richter and Rupamanjari Majumder and Stefan Luther},
title = {Dissolution of spiral wave’s core using cardiac optogenetics},
journal = {PLoS Computational Biology},
year = {2023},
volume = {19},
publisher = {Public Library of Science (PLoS)},
month = {dec},
url = {https://doi.org/10.1371/journal.pcbi.1011660},
number = {12},
pages = {e1011660},
doi = {10.1371/journal.pcbi.1011660}
}
MLA
Cite this
MLA Copy
Hussaini, Sayedeh, et al. “Dissolution of spiral wave’s core using cardiac optogenetics.” PLoS Computational Biology, vol. 19, no. 12, Dec. 2023, p. e1011660. https://doi.org/10.1371/journal.pcbi.1011660.