Open Access
Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle
Sebastian O Wendel
1
,
Sailesh Menon
2
,
Hamad Alshetaiwi
3
,
Tej B Shrestha
4
,
Lauren Chlebanowski
5
,
Wei-Wen Hsu
6
,
Stefan H Bossmann
7
,
Sanjeev Narayanan
2
,
Deryl L. Troyer
4
5
Department of Chemistry, Augustana College, Rock Island, Illinois, United States of America
|
Publication type: Journal Article
Publication date: 2015-05-26
scimago Q1
wos Q2
SJR: 0.803
CiteScore: 5.4
Impact factor: 2.6
ISSN: 19326203
PubMed ID:
26011247
Multidisciplinary
Abstract
The recent WHO report on antibiotic resistances shows a dramatic increase of microbial resistance against antibiotics. With only a few new antibiotics in the pipeline, a different drug delivery approach is urgently needed. We have obtained evidence demonstrating the effectiveness of a cell based drug delivery system that utilizes the innate immune system as targeting carrier for antibacterial drugs. In this study we show the efficient loading of neutrophil granulocytes with chlorhexidine and the complete killing of E. coli as well as Fusobacterium necrophorum in in-vitro studies. Fusobacterium necrophorum causes hepatic abscesses in cattle fed high grain diets. We also show in a mouse model that this delivery system targets infections of F. necrophorum in the liver and reduces the bacterial burden by an order of magnitude from approximately 2•106 to 1•105.
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17
Total citations:
17
Citations from 2024:
4
(23.52%)
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GOST
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Wendel S. O. et al. Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle // PLoS ONE. 2015. Vol. 10. No. 5. p. e0128144.
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Wendel S. O., Menon S., Alshetaiwi H., Shrestha T. B., Chlebanowski L., Hsu W., Bossmann S. H., Narayanan S., Troyer D. L. Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle // PLoS ONE. 2015. Vol. 10. No. 5. p. e0128144.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1371/journal.pone.0128144
UR - https://doi.org/10.1371/journal.pone.0128144
TI - Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle
T2 - PLoS ONE
AU - Wendel, Sebastian O
AU - Menon, Sailesh
AU - Alshetaiwi, Hamad
AU - Shrestha, Tej B
AU - Chlebanowski, Lauren
AU - Hsu, Wei-Wen
AU - Bossmann, Stefan H
AU - Narayanan, Sanjeev
AU - Troyer, Deryl L.
PY - 2015
DA - 2015/05/26
PB - Public Library of Science (PLoS)
SP - e0128144
IS - 5
VL - 10
PMID - 26011247
SN - 1932-6203
ER -
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BibTex (up to 50 authors)
Copy
@article{2015_Wendel,
author = {Sebastian O Wendel and Sailesh Menon and Hamad Alshetaiwi and Tej B Shrestha and Lauren Chlebanowski and Wei-Wen Hsu and Stefan H Bossmann and Sanjeev Narayanan and Deryl L. Troyer},
title = {Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle},
journal = {PLoS ONE},
year = {2015},
volume = {10},
publisher = {Public Library of Science (PLoS)},
month = {may},
url = {https://doi.org/10.1371/journal.pone.0128144},
number = {5},
pages = {e0128144},
doi = {10.1371/journal.pone.0128144}
}
Cite this
MLA
Copy
Wendel, Sebastian O., et al. “Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle.” PLoS ONE, vol. 10, no. 5, May. 2015, p. e0128144. https://doi.org/10.1371/journal.pone.0128144.