Open Access
PLoS ONE, volume 11, issue 1, pages e0147330
No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
Rankinen Tuomo
1
,
Fuku Noriyuki
2
,
Wolfarth Bernd
3
,
Wang Guan
4
,
Sarzynski Mark A.
5
,
Alexeev Dmitry G
6
,
Ahmetov Ildus I.
7
,
BOULAY MARCEL R.
8
,
Cieszczyk Pawel
9
,
Eynon Nir
10
,
Filipenko Maxim L
11
,
Garton Fleur C
12
,
GOVORUN VADIM M.
6
,
Houweling Peter J
11
,
Kawahara Takashi
13
,
Kostryukova Elena S.
6
,
Larin Andrey K.
6
,
Maciejewska-Karłowska Agnieszka
14
,
Miyachi Motohiko
15
,
Muniesa Carlos A.
16
,
Murakami Haruka
15
,
Ospanova Elena A.
6
,
PADMANABHAN SANDOSH
17
,
Pavlenko Alexander V.
6
,
Pyankova Olga N
11
,
Santiago Catalina
16
,
Sawczuk Marek
14
,
Scott Robert A
18
,
Uyba Vladimir V
19
,
Yvert Thomas
16
,
Perusse Louis
8
,
Ghosh Sujoy
20
,
Rauramaa Rainer
21
,
North Kathryn N.
12
,
Lucia Alejandro
16
,
Pitsiladis Yannis
4
,
BOUCHARD CLAUDE
1
1
Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
|
2
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan
|
4
Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton, Eastbourne, United Kingdom
|
5
Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America,
|
8
Department of Kinesiology, Laval University, Ste-Foy, Québec, Canada
|
9
University of Szczecin, Department of Physical Education and Health Promotion, Szczecin, Poland,
|
10
12
13
Department of Sports Medicine, Japan Institute of Sports Sciences, Tokyo, Japan
|
14
University of Szczecin, Department of Physical Education and Health Promotion, Szczecin, Poland
|
15
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan
|
16
Universidad Europea and Research Institute i+12, Madrid, Spain
|
19
Federal Medical Biological Agency, Moscow, Russia
|
20
Cardiovascular & Metabolic Disorders Program, and Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore, Singapore
|
Publication type: Journal Article
Publication date: 2016-01-29
Multidisciplinary
Abstract
There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Rankinen T. et al. No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes // PLoS ONE. 2016. Vol. 11. No. 1. p. e0147330.
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Rankinen T., Fuku N., Wolfarth B., Wang G., Sarzynski M. A., Alexeev D. G., Ahmetov I. I., BOULAY M. R., Cieszczyk P., Eynon N., Filipenko M. L., Garton F. C., Generozov E. V., GOVORUN V. M., Houweling P. J., Kawahara T., Kostryukova E. S., Kulemin N. A., Larin A. K., Maciejewska-Karłowska A., Miyachi M., Muniesa C. A., Murakami H., Ospanova E. A., PADMANABHAN S., Pavlenko A. V., Pyankova O. N., Santiago C., Sawczuk M., Scott R. A., Uyba V. V., Yvert T., Perusse L., Ghosh S., Rauramaa R., North K. N., Lucia A., Pitsiladis Y., BOUCHARD C. No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes // PLoS ONE. 2016. Vol. 11. No. 1. p. e0147330.
Cite this
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TY - JOUR
DO - 10.1371/journal.pone.0147330
UR - https://doi.org/10.1371%2Fjournal.pone.0147330
TI - No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
T2 - PLoS ONE
AU - Rankinen, Tuomo
AU - Fuku, Noriyuki
AU - Wolfarth, Bernd
AU - Wang, Guan
AU - Sarzynski, Mark A.
AU - Alexeev, Dmitry G
AU - Ahmetov, Ildus I.
AU - BOULAY, MARCEL R.
AU - Cieszczyk, Pawel
AU - Eynon, Nir
AU - Filipenko, Maxim L
AU - Garton, Fleur C
AU - Generozov, Edward V.
AU - GOVORUN, VADIM M.
AU - Houweling, Peter J
AU - Kawahara, Takashi
AU - Kostryukova, Elena S.
AU - Kulemin, Nickolay A.
AU - Larin, Andrey K.
AU - Maciejewska-Karłowska, Agnieszka
AU - Miyachi, Motohiko
AU - Muniesa, Carlos A.
AU - Murakami, Haruka
AU - Ospanova, Elena A.
AU - PADMANABHAN, SANDOSH
AU - Pavlenko, Alexander V.
AU - Pyankova, Olga N
AU - Santiago, Catalina
AU - Sawczuk, Marek
AU - Scott, Robert A
AU - Uyba, Vladimir V
AU - Yvert, Thomas
AU - Perusse, Louis
AU - Ghosh, Sujoy
AU - Rauramaa, Rainer
AU - North, Kathryn N.
AU - Lucia, Alejandro
AU - Pitsiladis, Yannis
AU - BOUCHARD, CLAUDE
PY - 2016
DA - 2016/01/29 00:00:00
PB - Public Library of Science (PLoS)
SP - e0147330
IS - 1
VL - 11
SN - 1932-6203
ER -
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@article{2016_Rankinen,
author = {Tuomo Rankinen and Noriyuki Fuku and Bernd Wolfarth and Guan Wang and Mark A. Sarzynski and Dmitry G Alexeev and Ildus I. Ahmetov and MARCEL R. BOULAY and Pawel Cieszczyk and Nir Eynon and Maxim L Filipenko and Fleur C Garton and Edward V. Generozov and VADIM M. GOVORUN and Peter J Houweling and Takashi Kawahara and Elena S. Kostryukova and Nickolay A. Kulemin and Andrey K. Larin and Agnieszka Maciejewska-Karłowska and Motohiko Miyachi and Carlos A. Muniesa and Haruka Murakami and Elena A. Ospanova and SANDOSH PADMANABHAN and Alexander V. Pavlenko and Olga N Pyankova and Catalina Santiago and Marek Sawczuk and Robert A Scott and Vladimir V Uyba and Thomas Yvert and Louis Perusse and Sujoy Ghosh and Rainer Rauramaa and Kathryn N. North and Alejandro Lucia and Yannis Pitsiladis and CLAUDE BOUCHARD},
title = {No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes},
journal = {PLoS ONE},
year = {2016},
volume = {11},
publisher = {Public Library of Science (PLoS)},
month = {jan},
url = {https://doi.org/10.1371%2Fjournal.pone.0147330},
number = {1},
pages = {e0147330},
doi = {10.1371/journal.pone.0147330}
}
Cite this
MLA
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Rankinen, Tuomo, et al. “No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes.” PLoS ONE, vol. 11, no. 1, Jan. 2016, p. e0147330. https://doi.org/10.1371%2Fjournal.pone.0147330.
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