Open Access
Open access
Public Library of Science (PLoS)
PLoS ONE
,  volume 17 ,  issue 3 ,  pages e0265085

Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis

Yiqun Miao 1
, 
Yang Xu 1
, 
Teng Ping 2
, 
AIHUA WANG 1
, 
Yuanyuan Zhang 1
, 
Yun Zhou 1
, 
Wenwen Liu 1
1
 
2
 
Delivery Room, Weifang Maternal and Child Health Care Hospital, Weifang, Shandong, China | 
Publication type: Journal Article
Publication date: 2022-03-10
Public Library of Science (PLoS)
scimago Q1
wos Q2
SJR: 0.803
CiteScore: 5.4
Impact factor: 2.6
ISSN: 19326203
Multidisciplinary
Abstract
Background

Hyperthyroidism affects about 0.2%-2.7% of all pregnancies, and is generally treated with propylthiouracil (PTU). However, previous studies about the effects of propylthiouracil on maternal or foetal are contentious.
Objective

This meta-analysis was carried out to investigate the safety and efficacy of propylthiouracil during pregnancy.
Materials and methods

PubMed, EBSCO, Embase, Scopus, Web of Science, Cochrane, CNKI, Wanfang and VIP database were searched from inception until August 31, 2021 for all available randomized controlled trials (RCTs) or cohort studies that evaluated the efficacy of propylthiouracil and its effects on pregnancy outcomes. Odds ratio (OR) and 95% confidence interval (CI) were used for binary variables, weighted mean difference (WMD) and 95% confidence interval (CI) were used for continuous variables. RevMan5.4 and Stata 16.0 were used for performing the meta-analysis.
Results

The researchers examined data from 13 randomized controlled trials and cohort studies involving 18948 infants. Congenital anomalies were not significantly associated with PTU in the pooled results (OR = 1.03, 95%CI: 0.84–1.25, P = 0.80, I2 = 40.3%). There were no statistically significant differences in neonatal hypothyroidism (OR = 0.55, 95%CI: 0.06–4.92, P = 0.593, I2 = 57.0%) or hepatotoxicity (OR = 0.34, 95%CI: 0.08–1.48, P = 0.151, I2 = 0.0%) exposed to PTU compared to the control group. The serum levels of FT3, FT4, TT3, and TT4 were significantly lower in the propylthiouracil group compared to the control group.
Conclusion

This meta-analysis confirmed the beneficial effects of propylthiouracil treatment, namely the risks of adverse pregnancy outcomes were not increased, and it also proved PTU’s efficacy in the treatment of pregnant women with hyperthyroidism. The findings supported the use of propylthiouracil during pregnancy with hyperthyroidism in order to improve clinical pregnancy outcomes in patients with thyroid dysfunction.

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GOST |
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GOST Copy
Miao Y. et al. Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis // PLoS ONE. 2022. Vol. 17. No. 3. p. e0265085.
GOST all authors (up to 50) Copy
Miao Y., Xu Y., Ping T., WANG A., Zhang Y., Zhou Y., Liu W. Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis // PLoS ONE. 2022. Vol. 17. No. 3. p. e0265085.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1371/journal.pone.0265085
UR - https://doi.org/10.1371/journal.pone.0265085
TI - Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis
T2 - PLoS ONE
AU - Miao, Yiqun
AU - Xu, Yang
AU - Ping, Teng
AU - WANG, AIHUA
AU - Zhang, Yuanyuan
AU - Zhou, Yun
AU - Liu, Wenwen
PY - 2022
DA - 2022/03/10
PB - Public Library of Science (PLoS)
SP - e0265085
IS - 3
VL - 17
PMID - 35271661
SN - 1932-6203
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Miao,
author = {Yiqun Miao and Yang Xu and Teng Ping and AIHUA WANG and Yuanyuan Zhang and Yun Zhou and Wenwen Liu},
title = {Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis},
journal = {PLoS ONE},
year = {2022},
volume = {17},
publisher = {Public Library of Science (PLoS)},
month = {mar},
url = {https://doi.org/10.1371/journal.pone.0265085},
number = {3},
pages = {e0265085},
doi = {10.1371/journal.pone.0265085}
}
MLA
Cite this
MLA Copy
Miao, Yiqun, et al. “Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis.” PLoS ONE, vol. 17, no. 3, Mar. 2022, p. e0265085. https://doi.org/10.1371/journal.pone.0265085.