Open Access
PLoS ONE, volume 10, issue 6, pages e0128677
Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent
Seutter von Loetzen Christian
1
,
Jacob Thessa
1
,
Hartl-Spiegelhauer Olivia
1
,
Vogel Lothar
2
,
Schiller Dirk
2
,
Spörlein Güttler Cornelia
3
,
Schobert Rainer
3
,
Vieths Stefan
2
,
Hartl Maximilian Johannes
1
,
RÖSCH Paul
1
2
Division of Allergology, Paul-Ehrlich-Institut, Langen, Hesse, Germany
|
Publication type: Journal Article
Publication date: 2015-06-04
Multidisciplinary
Abstract
Each spring millions of patients suffer from allergies when birch pollen is released into the air. In most cases, the major pollen allergen Bet v 1 is the elicitor of the allergy symptoms. Bet v 1 comes in a variety of isoforms that share virtually identical conformations, but their relative concentrations are plant-specific. Glycosylated flavonoids, such as quercetin-3-O-sophoroside, are the physiological ligands of Bet v 1, and here we found that three isoforms differing in their allergenic potential also show an individual, highly specific binding behaviour for the different ligands. This specificity is driven by the sugar moieties of the ligands rather than the flavonols. While the influence of the ligands on the allergenicity of the Bet v 1 isoforms may be limited, the isoform and ligand mixtures add up to a complex and thus individual fingerprint of the pollen. We suggest that this mixture is not only acting as an effective chemical sunscreen for pollen DNA, but may also play an important role in recognition processes during pollination.
Citations by journals
|
1
2
3
4
|
|
|
Scientific Reports
|
Scientific Reports
4 publications, 14.81%
|
|
Current Allergy and Asthma Reports
|
Current Allergy and Asthma Reports
2 publications, 7.41%
|
|
Molecular Nutrition and Food Research
|
Molecular Nutrition and Food Research
2 publications, 7.41%
|
|
Allergy: European Journal of Allergy and Clinical Immunology
|
Allergy: European Journal of Allergy and Clinical Immunology
2 publications, 7.41%
|
|
Current Protein and Peptide Science
|
Current Protein and Peptide Science
1 publication, 3.7%
|
|
Foods
|
Foods
1 publication, 3.7%
|
|
Frontiers in Plant Science
|
Frontiers in Plant Science
1 publication, 3.7%
|
|
Frontiers in Molecular Biosciences
|
Frontiers in Molecular Biosciences
1 publication, 3.7%
|
|
Analytical and Bioanalytical Chemistry
|
Analytical and Bioanalytical Chemistry
1 publication, 3.7%
|
|
BMC Plant Biology
|
BMC Plant Biology
1 publication, 3.7%
|
|
Nature Reviews Molecular Cell Biology
|
Nature Reviews Molecular Cell Biology
1 publication, 3.7%
|
|
PLoS ONE
|
PLoS ONE
1 publication, 3.7%
|
|
Revue Francaise d'Allergologie
|
Revue Francaise d'Allergologie
1 publication, 3.7%
|
|
Molecular Immunology
|
Molecular Immunology
1 publication, 3.7%
|
|
Clinical and Experimental Allergy
|
Clinical and Experimental Allergy
1 publication, 3.7%
|
|
ChemBioChem
|
ChemBioChem
1 publication, 3.7%
|
|
Pediatric Allergy and Immunology
|
Pediatric Allergy and Immunology
1 publication, 3.7%
|
|
Expert Review of Clinical Immunology
|
Expert Review of Clinical Immunology
1 publication, 3.7%
|
|
Proceedings of the National Academy of Sciences of Belarus Biological Series
|
Proceedings of the National Academy of Sciences of Belarus Biological Series
1 publication, 3.7%
|
|
Biomolecules
|
Biomolecules
1 publication, 3.7%
|
|
1
2
3
4
|
Citations by publishers
|
1
2
3
4
5
6
7
8
9
|
|
|
Springer Nature
|
Springer Nature
9 publications, 33.33%
|
|
Wiley
|
Wiley
7 publications, 25.93%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 7.41%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
2 publications, 7.41%
|
|
Elsevier
|
Elsevier
2 publications, 7.41%
|
|
Bentham Science
|
Bentham Science
1 publication, 3.7%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
1 publication, 3.7%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 3.7%
|
|
Publishing House Belorusskaya Nauka
|
Publishing House Belorusskaya Nauka
1 publication, 3.7%
|
|
1
2
3
4
5
6
7
8
9
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,0,4,5,6,2,2,4,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["3.7",0,"14.81","18.52","22.22","7.41","7.41","14.81","11.11"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Scientific Reports","Current Allergy and Asthma Reports","Molecular Nutrition and Food Research","Allergy: European Journal of Allergy and Clinical Immunology","Current Protein and Peptide Science","Foods","Frontiers in Plant Science","Frontiers in Molecular Biosciences","Analytical and Bioanalytical Chemistry","BMC Plant Biology","Nature Reviews Molecular Cell Biology","PLoS ONE","Revue Francaise d'Allergologie","Molecular Immunology","Clinical and Experimental Allergy","ChemBioChem","Pediatric Allergy and Immunology","Expert Review of Clinical Immunology","Proceedings of the National Academy of Sciences of Belarus Biological Series","Biomolecules"],"ids":[13767,16563,990,24326,9565,11536,1823,3133,10563,16146,10207,24963,9515,24310,1010,12154,7690,2713,31055,13780],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/tvVQSBSep48GAK9gpD5VCB0Daoe9RfnbbZFBX9mh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[4,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.81,7.41,7.41,7.41,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Wiley","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","Elsevier","Bentham Science","Public Library of Science (PLoS)","Taylor & Francis","Publishing House Belorusskaya Nauka"],"ids":[8,11,202,208,17,39,344,18,7271],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/tvVQSBSep48GAK9gpD5VCB0Daoe9RfnbbZFBX9mh_medium.webp"],"datasets":[{"label":"","data":[9,7,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,25.93,7.41,7.41,7.41,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Seutter von Loetzen C. et al. Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent // PLoS ONE. 2015. Vol. 10. No. 6. p. e0128677.
GOST all authors (up to 50)
Copy
Seutter von Loetzen C., Jacob T., Hartl-Spiegelhauer O., Vogel L., Schiller D., Spörlein Güttler C., Schobert R., Vieths S., Hartl M. J., RÖSCH P. Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent // PLoS ONE. 2015. Vol. 10. No. 6. p. e0128677.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1371/journal.pone.0128677
UR - https://doi.org/10.1371%2Fjournal.pone.0128677
TI - Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent
T2 - PLoS ONE
AU - Seutter von Loetzen, Christian
AU - Jacob, Thessa
AU - Hartl-Spiegelhauer, Olivia
AU - Vogel, Lothar
AU - Schiller, Dirk
AU - Spörlein Güttler, Cornelia
AU - Schobert, Rainer
AU - Vieths, Stefan
AU - Hartl, Maximilian Johannes
AU - RÖSCH, Paul
PY - 2015
DA - 2015/06/04 00:00:00
PB - Public Library of Science (PLoS)
SP - e0128677
IS - 6
VL - 10
SN - 1932-6203
ER -
Cite this
BibTex
Copy
@article{2015_Seutter von Loetzen,
author = {Christian Seutter von Loetzen and Thessa Jacob and Olivia Hartl-Spiegelhauer and Lothar Vogel and Dirk Schiller and Cornelia Spörlein Güttler and Rainer Schobert and Stefan Vieths and Maximilian Johannes Hartl and Paul RÖSCH},
title = {Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent},
journal = {PLoS ONE},
year = {2015},
volume = {10},
publisher = {Public Library of Science (PLoS)},
month = {jun},
url = {https://doi.org/10.1371%2Fjournal.pone.0128677},
number = {6},
pages = {e0128677},
doi = {10.1371/journal.pone.0128677}
}
Cite this
MLA
Copy
Seutter von Loetzen, Christian, et al. “Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent.” PLoS ONE, vol. 10, no. 6, Jun. 2015, p. e0128677. https://doi.org/10.1371%2Fjournal.pone.0128677.