Open Access
Open access
Public Library of Science (PLoS)
PLoS ONE
,  volume 16 ,  issue 1 January ,  pages e0245159

Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum

Alexandr Kurkov 1
, 
Anna Guller 1
, 
Alexey Fayzullin 1
, 
Nafisa Fayzullinа 2
, 
Vladimir Plyakin 3
, 
Svetlana Kotova 1
, 
Petr Timashev 1
, 
Anastasia Frolova 4
, 
Nikita Kurtak 5
, 
Vyacheslav Paukov 6
, 
Anatoly Shekhter 4
1
 
2
 
3
 
Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia | 
4
 
5
 
6
 
Publication type: Journal Article
Publication date: 2021-01-25
Public Library of Science (PLoS)
scimago Q1
wos Q2
SJR: 0.803
CiteScore: 5.4
Impact factor: 2.6
ISSN: 19326203
Multidisciplinary
Abstract
Background

It is unclear if amianthoid transformation (AT) of costal cartilage extracellular matrix (ECM) has an impact on the development of pectus excavatum (PE) and pectus carinatum (PC).
Methods

AT foci were examined in intrasurgical biopsy specimens of costal cartilages of children (8–17 years old) with PE (n = 12) and PC (n = 12) and in age-matching autopsy control samples (n = 10) using histological and immunohistochemical staining, atomic force and nonlinear optical microscopy, transmission and scanning electron microscopy, morphometry and statistics.
Results

AT areas were identified in the costal cartilage ECM in children with normal chest, PE and PC. Each type of the AT areas (“canonical”, “intertwined”, “fine-fibred” and “intralacunary”) had a unique morphological pattern of thickness and alignment of amianthoid fibers (AFs). AFs were formed via lateral aggregation of collagen type II fibrils in the intact ECM. Foci of the AT were observed significantly more frequently in the PE and PC groups. The AT areas had unique quantitative features in each study group.
Conclusion

AT is a structurally diverse form of ECM alteration present in healthy and pathological costal cartilage. PE and PC are associated with specific AT disorders.

Found 
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GOST |
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GOST Copy
Kurkov A. et al. Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum // PLoS ONE. 2021. Vol. 16. No. 1 January. p. e0245159.
GOST all authors (up to 50) Copy
Kurkov A., Guller A., Fayzullin A., Fayzullinа N., Plyakin V., Kotova S., Timashev P., Frolova A., Kurtak N., Paukov V., Shekhter A. Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum // PLoS ONE. 2021. Vol. 16. No. 1 January. p. e0245159.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1371/journal.pone.0245159
UR - https://doi.org/10.1371/journal.pone.0245159
TI - Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum
T2 - PLoS ONE
AU - Kurkov, Alexandr
AU - Guller, Anna
AU - Fayzullin, Alexey
AU - Fayzullinа, Nafisa
AU - Plyakin, Vladimir
AU - Kotova, Svetlana
AU - Timashev, Petr
AU - Frolova, Anastasia
AU - Kurtak, Nikita
AU - Paukov, Vyacheslav
AU - Shekhter, Anatoly
PY - 2021
DA - 2021/01/25
PB - Public Library of Science (PLoS)
SP - e0245159
IS - 1 January
VL - 16
PMID - 33493174
SN - 1932-6203
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Kurkov,
author = {Alexandr Kurkov and Anna Guller and Alexey Fayzullin and Nafisa Fayzullinа and Vladimir Plyakin and Svetlana Kotova and Petr Timashev and Anastasia Frolova and Nikita Kurtak and Vyacheslav Paukov and Anatoly Shekhter},
title = {Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum},
journal = {PLoS ONE},
year = {2021},
volume = {16},
publisher = {Public Library of Science (PLoS)},
month = {jan},
url = {https://doi.org/10.1371/journal.pone.0245159},
number = {1 January},
pages = {e0245159},
doi = {10.1371/journal.pone.0245159}
}
MLA
Cite this
MLA Copy
Kurkov, Alexandr, et al. “Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum.” PLoS ONE, vol. 16, no. 1 January, Jan. 2021, p. e0245159. https://doi.org/10.1371/journal.pone.0245159.