Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver Disease

Publication type: Journal Article
Publication date: 2025-01-21
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 2.344
CiteScore: 10.3
Impact factor: 7.6
ISSN: 00029270, 15720241
Abstract

The number of alcohol use disorder patients with mild (n = 101) and severe alcoholic liver disease (n = 112) increased between 2013 and 2023 (P = 0.06). Naltrexone was prescribed in 65%, acamprosate in 26%, and disulfiram in 9%. Internal medicine providers were the most frequent prescribers (51%), followed by psychiatry (30%) and gastroenterology/hepatology (9%) (P = 0.001). Duration of use was longest with naltrexone compared with acamprosate and disulfiram (360 vs 251 vs 190 days, P = 0.032). The rate of alcohol use disorder medication discontinuation for adverse events was similar in both groups (14% vs 12%). Naltrexone, acamprosate, and disulfiram are increasingly being prescribed in American patients with mild and severe alcohol-related liver disease with similar tolerability and efficacy.

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Shenoy A. et al. Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver Disease // American Journal of Gastroenterology. 2025.
GOST all authors (up to 50) Copy
Shenoy A., Jasty V. S., Uttal S., Nasser S., Winder G. S., Mellinger J., Fontana R. J. Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver Disease // American Journal of Gastroenterology. 2025.
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TY - JOUR
DO - 10.14309/ajg.0000000000003328
UR - https://journals.lww.com/10.14309/ajg.0000000000003328
TI - Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver Disease
T2 - American Journal of Gastroenterology
AU - Shenoy, Abhishek
AU - Jasty, Venkata Sai
AU - Uttal, Sarah
AU - Nasser, Sarah
AU - Winder, Gerald Scott
AU - Mellinger, Jessica
AU - Fontana, Robert J.
PY - 2025
DA - 2025/01/21
PB - Ovid Technologies (Wolters Kluwer Health)
SN - 0002-9270
SN - 1572-0241
ER -
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BibTex (up to 50 authors) Copy
@article{2025_Shenoy,
author = {Abhishek Shenoy and Venkata Sai Jasty and Sarah Uttal and Sarah Nasser and Gerald Scott Winder and Jessica Mellinger and Robert J. Fontana},
title = {Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver Disease},
journal = {American Journal of Gastroenterology},
year = {2025},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {jan},
url = {https://journals.lww.com/10.14309/ajg.0000000000003328},
doi = {10.14309/ajg.0000000000003328}
}