Open Access
Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний
Publication type: Journal Article
Publication date: 2017-01-01
scimago Q4
SJR: 0.149
CiteScore: 1.7
Impact factor: —
ISSN: 19954484, 19954492
Immunology
Immunology and Allergy
Rheumatology
Abstract
The paper analyzes the key biological effects of cytokines that play a central role in the pathogenesis of immunoinflammatory rheumatic diseases. Special attention is drawn to major proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-17. There are data from a preclinical study of the innovative original biological agents (BAs) designed by the JSC «BIOCAD»: BCD-085, a humanized anti-IL-17 monoclonal antibody, BCD-089, a humanized anti-IL-6 receptor monoclonal antibody, and BCD-121, a humanized bispecific antiTNF-α and anti-IL-17 monoclonal antibody. The preclinical findings prove the specific activity of the drugs in suppressing the inflammatory process, as well as the low toxicity and good tolerance in animals, which could justify investigation of the the drugs during human clinical trials and open up prospects for effective and affordable treatment in Russian patients.
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17
Total citations:
17
Citations from 2024:
2
(11%)
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GOST
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Nasonov E. L. et al. Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний // Nauchno-Prakticheskaya Revmatologiya. 2017. Vol. 55. No. 2. pp. 201-210.
GOST all authors (up to 50)
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Nasonov E. L., Mazurov V. I., Usacheva Yu. V., Chernyaeva E. V., Ustyugov Ya. Yu., Ulitin A. B., Ivanov R. A. Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний // Nauchno-Prakticheskaya Revmatologiya. 2017. Vol. 55. No. 2. pp. 201-210.
Cite this
RIS
Copy
TY - JOUR
DO - 10.14412/1995-4484-2017-201-210
UR - https://doi.org/10.14412/1995-4484-2017-201-210
TI - Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний
T2 - Nauchno-Prakticheskaya Revmatologiya
AU - Nasonov, E L
AU - Mazurov, V I
AU - Usacheva, Yu V
AU - Chernyaeva, E V
AU - Ustyugov, Ya Yu
AU - Ulitin, A B
AU - Ivanov, R. A.
PY - 2017
DA - 2017/01/01
PB - Mediar Press
SP - 201-210
IS - 2
VL - 55
SN - 1995-4484
SN - 1995-4492
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Nasonov,
author = {E L Nasonov and V I Mazurov and Yu V Usacheva and E V Chernyaeva and Ya Yu Ustyugov and A B Ulitin and R. A. Ivanov},
title = {Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний},
journal = {Nauchno-Prakticheskaya Revmatologiya},
year = {2017},
volume = {55},
publisher = {Mediar Press},
month = {jan},
url = {https://doi.org/10.14412/1995-4484-2017-201-210},
number = {2},
pages = {201--210},
doi = {10.14412/1995-4484-2017-201-210}
}
Cite this
MLA
Copy
Nasonov, E. L., et al. “Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний.” Nauchno-Prakticheskaya Revmatologiya, vol. 55, no. 2, Jan. 2017, pp. 201-210. https://doi.org/10.14412/1995-4484-2017-201-210.
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