Open Access
Nauchno-Prakticheskaya Revmatologiya, volume 55, issue 2, pages 201-210
Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний
Publication type: Journal Article
Publication date: 2017-01-01
Journal:
Nauchno-Prakticheskaya Revmatologiya
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 19954484, 19954492
Immunology
Immunology and Allergy
Rheumatology
Abstract
The paper analyzes the key biological effects of cytokines that play a central role in the pathogenesis of immunoinflammatory rheumatic diseases. Special attention is drawn to major proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-17. There are data from a preclinical study of the innovative original biological agents (BAs) designed by the JSC «BIOCAD»: BCD-085, a humanized anti-IL-17 monoclonal antibody, BCD-089, a humanized anti-IL-6 receptor monoclonal antibody, and BCD-121, a humanized bispecific antiTNF-α and anti-IL-17 monoclonal antibody. The preclinical findings prove the specific activity of the drugs in suppressing the inflammatory process, as well as the low toxicity and good tolerance in animals, which could justify investigation of the the drugs during human clinical trials and open up prospects for effective and affordable treatment in Russian patients.
Citations by journals
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Nauchno-Prakticheskaya Revmatologiya
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Nauchno-Prakticheskaya Revmatologiya, 7, 46.67%
Nauchno-Prakticheskaya Revmatologiya
7 publications, 46.67%
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Bulletin of Rehabilitation Medicine
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Bulletin of Rehabilitation Medicine, 1, 6.67%
Bulletin of Rehabilitation Medicine
1 publication, 6.67%
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Vestnik dermatologii i venerologii
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Vestnik dermatologii i venerologii, 1, 6.67%
Vestnik dermatologii i venerologii
1 publication, 6.67%
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Vestnik Oftalmologii
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Vestnik Oftalmologii
1 publication, 6.67%
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Klinicheskaya Dermatologiya i Venerologiya
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Klinicheskaya Dermatologiya i Venerologiya
1 publication, 6.67%
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Modern Rheumatology Journal (Sovremennaya Revmatologiya)
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Modern Rheumatology Journal (Sovremennaya Revmatologiya), 1, 6.67%
Modern Rheumatology Journal (Sovremennaya Revmatologiya)
1 publication, 6.67%
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Russian Ophthalmological Journal (Rossiiskii Oftal'mologicheskii Zhurnal)
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Russian Ophthalmological Journal (Rossiiskii Oftal'mologicheskii Zhurnal), 1, 6.67%
Russian Ophthalmological Journal (Rossiiskii Oftal'mologicheskii Zhurnal)
1 publication, 6.67%
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Terapevticheskii Arkhiv
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Terapevticheskii Arkhiv, 1, 6.67%
Terapevticheskii Arkhiv
1 publication, 6.67%
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Klinicheskaya Onkogematologiya/Clinical Oncohematology
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Klinicheskaya Onkogematologiya/Clinical Oncohematology, 1, 6.67%
Klinicheskaya Onkogematologiya/Clinical Oncohematology
1 publication, 6.67%
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Citations by publishers
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Mediar Press
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Mediar Press, 7, 46.67%
Mediar Press
7 publications, 46.67%
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Media Sphere Publishing Group
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Media Sphere Publishing Group
2 publications, 13.33%
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National Medical Research Center For Rehabilitation And Balneology
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National Medical Research Center For Rehabilitation And Balneology, 1, 6.67%
National Medical Research Center For Rehabilitation And Balneology
1 publication, 6.67%
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Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov
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Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov, 1, 6.67%
Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov
1 publication, 6.67%
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IMA Press, LLC
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IMA Press, LLC, 1, 6.67%
IMA Press, LLC
1 publication, 6.67%
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Real Time, Ltd.
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Real Time, Ltd., 1, 6.67%
Real Time, Ltd.
1 publication, 6.67%
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Consilium Medicum
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Consilium Medicum, 1, 6.67%
Consilium Medicum
1 publication, 6.67%
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Practical Medicine Publishing House
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Practical Medicine Publishing House, 1, 6.67%
Practical Medicine Publishing House
1 publication, 6.67%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nasonov E. L. et al. Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний // Nauchno-Prakticheskaya Revmatologiya. 2017. Vol. 55. No. 2. pp. 201-210.
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Nasonov E. L., Mazurov V. I., Usacheva Yu. V., Chernyaeva E. V., Ustyugov Ya. Yu., Ulitin A. B., Ivanov R. A. Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний // Nauchno-Prakticheskaya Revmatologiya. 2017. Vol. 55. No. 2. pp. 201-210.
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TY - JOUR
DO - 10.14412/1995-4484-2017-201-210
UR - https://doi.org/10.14412%2F1995-4484-2017-201-210
TI - Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний
T2 - Nauchno-Prakticheskaya Revmatologiya
AU - Nasonov, E L
AU - Mazurov, V I
AU - Usacheva, Yu V
AU - Chernyaeva, E V
AU - Ustyugov, Ya Yu
AU - Ulitin, A B
AU - Ivanov, R. A.
PY - 2017
DA - 2017/01/01 00:00:00
PB - Mediar Press
SP - 201-210
IS - 2
VL - 55
SN - 1995-4484
SN - 1995-4492
ER -
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@article{2017_Nasonov,
author = {E L Nasonov and V I Mazurov and Yu V Usacheva and E V Chernyaeva and Ya Yu Ustyugov and A B Ulitin and R. A. Ivanov},
title = {Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний},
journal = {Nauchno-Prakticheskaya Revmatologiya},
year = {2017},
volume = {55},
publisher = {Mediar Press},
month = {jan},
url = {https://doi.org/10.14412%2F1995-4484-2017-201-210},
number = {2},
pages = {201--210},
doi = {10.14412/1995-4484-2017-201-210}
}
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MLA
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Nasonov, E. L., et al. “Разработки отечественных оригинальных генно-инженерных биологических препаратов для лечения иммуновоспалительных ревматических заболеваний.” Nauchno-Prakticheskaya Revmatologiya, vol. 55, no. 2, Jan. 2017, pp. 201-210. https://doi.org/10.14412%2F1995-4484-2017-201-210.
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