Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID)
Giuseppe Citerio
1, 2
,
Giacomo Grasselli
3, 4
,
Maurizio Cecconi
5, 6
,
Laura Antolini
1
,
Massimo Borelli
7
,
Federica De Giacomi
8
,
Giancarlo Bosio
8
,
Nicola Latronico
9, 10
,
Matteo Filippini
10
,
Marco Gemma
11
,
Claudia Giannotti
12
,
Benvenuto Antonini
13
,
Nicola Petrucci
14
,
Simone Maria Zerbi
15
,
Paolo Maniglia
16
,
Gian Paolo Castelli
17
,
Giovanni Marino
18
,
Matteo Subert
19
,
Giuseppe Citerio
1, 2, 20
,
DANILO RADRIZZANI
21
,
Teresa S. Mediani
22
,
Ferdinando Luca Lorini
23
,
Filippo Maria Russo
23
,
Angela Faletti
24
,
Andrea Beindorf
25
,
Remo Daniel Covello
26
,
Stefano Greco
27
,
Marta M. Bizzarri
28
,
Giuseppe Ristagno
3
,
Francesco Mojoli
29
,
Andrea Pradella
5
,
Paolo Severgnini
30
,
Marta Da Macallè
30
,
Andrea Albertin
31
,
V. MARCO RANIERI
32
,
Emanuele Rezoagli
1, 2, 33
,
Giovanni Vitale
33
,
Aurora Magliocca
1, 33
,
Gianluca Cappelleri
34
,
Mattia Docci
1, 35
,
Stefano Aliberti
4, 36
,
Filippo Serra
1
,
Emanuela Rossi
1
,
Maria Grazia Valsecchi
1
,
Antonio Pesenti
3, 4
,
Giuseppe Foti
1, 2
3
Department of Anesthesia, Intensive Care and Emergency, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
|
4
Department of Pathophysiology and Transplantation, and
5
Department of Anaesthesia and Intensive Care Medicine, Humanitas Clinical and Research Center Istituto di Ricovero e Cura a Carattere Scientifico Milan, Italy
|
7
Department of Anesthesia and Intensive Care Medicine, Treviglio Caravaggio Hospital, Azienda Socio-Sanitaria Territoriale Bergamo Ovest, Treviglio, Italy
|
8
Division of Pulmonary Medicine, Cremona Hospital, ASST Cremona, Cremona, Italy
|
12
13
Department of Anesthesiology and Intensive Care Medicine, Manerbio Hospital, and
14
Department of Anesthesia and Intensive Care Unit, Desenzano Hospital, Azienda Socio-Sanitaria Territoriale Garda, Brescia, Italy
|
16
Department of Anesthesia and Intensive Care Medicine, Alessandro Manzoni Hospital, Azienda Socio-Sanitaria Territoriale Lecco, Lecco, Italy
|
17
Department of Anesthesia and Intensive Care Medicine, Carlo Poma Hospital, Azienda Socio-Sanitaria Territoriale Mantova, Mantova, Italy
|
18
Department of Anesthesia and Intensive Care Medicine, Vizzolo Predabissi Hospital, and
|
19
Department of Anesthesia and Intensive Care Medicine, Melzo-Gorgonzola Hospital, Azienda Socio-Sanitaria Territoriale Melegnano e della Martesana, Melegnano, Milan, Italy
|
20
Department of Anesthesia and Intensive Care Medicine, Desio Hospital, Azienda Socio-Sanitaria Territoriale Monza, Monza e Brianza, Italy
|
21
Department of Anesthesia and Intensive Care Medicine, Legnano Hospital, Azienda Socio-Sanitaria Territoriale Ovest milanese, Legnano, Milano, Italy
|
22
Department of Anesthesia and Intensive Care Medicine, Vigevano Hospital, Azienda Socio-Sanitaria Territoriale Pavia, Vigevano, Pavia, Italy
|
23
Department of Anesthesia and Intensive Care, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
|
24
Department of Anesthesia and Intensive Care Medicine, Gardone Val Trompia Hospital, and
|
26
Department of Anesthesia and Intensive Care Medicine, Busto Arsizio Hospital, and
|
27
Department of Anesthesia and Intensive Care Medicine, Saronno Hospital, Azienda Socio-Sanitaria Territoriale Valle Olona, Varese, Italy
|
28
Department of Anesthesia and Intensive Care Medicine, Vimercate Hospital, Azienda Socio-Sanitaria Territoriale Vimercate, Monza e Brianza, Italy
|
31
Department of Anesthesia and Intensive Care Medicine, San Giuseppe Hospital, Milan, Italy
|
33
Policlinico San Marco, San Donato Group Hospitals, Zingonia, Bergamo, Italy
|
34
Humanitas Gavazzeni, Bergamo, Italy
|
35
Policlinico San Pietro, Ponte San Pietro, Italy; and
|
36
Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy
|
Тип публикации: Journal Article
Дата публикации: 2021-01-04
scimago Q1
wos Q1
БС1
SJR: 1.652
CiteScore: 9.6
Impact factor: 5.4
ISSN: 23256621, 23296933
PubMed ID:
33395553
Pulmonary and Respiratory Medicine
Краткое описание
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use of NIV in COVID-19 is limited.Objectives: To describe the prevalence and clinical characteristics of patients with COVID-19 treated with NIV outside the ICUs. To investigate the factors associated with NIV failure (need for intubation or death).Methods: In this prospective, single-day observational study, we enrolled adult patients with COVID-19 who were treated with NIV outside the ICU from 31 hospitals in Lombardy, Italy.Results: We collected data on demographic and clinical characteristics, ventilatory management, and patient outcomes. Of 8,753 patients with COVID-19 present in the hospitals on the study day, 909 (10%) were receiving NIV outside the ICU. A majority of patients (778/909; 85%) patients were treated with continuous positive airway pressure (CPAP), which was delivered by helmet in 617 (68%) patients. NIV failed in 300 patients (37.6%), whereas 498 (62.4%) patients were discharged alive without intubation. Overall mortality was 25%. NIV failure occurred in 152/284 (53%) patients with an arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FiO2) ratio 60% and close to 75% in full-treatment patients. C-reactive protein, PaO2/FiO2, and platelet counts were independently associated with increased risk of NIV failure.Clinical trial registered with ClinicalTrials.gov (NCT04382235).
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ГОСТ
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Citerio G. et al. Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID) // Annals of the American Thoracic Society. 2021. Vol. 18. No. 6. pp. 1020-1026.
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Citerio G. et al. Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID) // Annals of the American Thoracic Society. 2021. Vol. 18. No. 6. pp. 1020-1026.
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TY - JOUR
DO - 10.1513/AnnalsATS.202008-1080OC
UR - https://doi.org/10.1513/AnnalsATS.202008-1080OC
TI - Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID)
T2 - Annals of the American Thoracic Society
AU - Citerio, Giuseppe
AU - Grasselli, Giacomo
AU - Cecconi, Maurizio
AU - Antolini, Laura
AU - Borelli, Massimo
AU - De Giacomi, Federica
AU - Bosio, Giancarlo
AU - Latronico, Nicola
AU - Filippini, Matteo
AU - Gemma, Marco
AU - Giannotti, Claudia
AU - Antonini, Benvenuto
AU - Petrucci, Nicola
AU - Zerbi, Simone Maria
AU - Maniglia, Paolo
AU - Castelli, Gian Paolo
AU - Marino, Giovanni
AU - Subert, Matteo
AU - Citerio, Giuseppe
AU - RADRIZZANI, DANILO
AU - Mediani, Teresa S.
AU - Lorini, Ferdinando Luca
AU - Russo, Filippo Maria
AU - Faletti, Angela
AU - Beindorf, Andrea
AU - Covello, Remo Daniel
AU - Greco, Stefano
AU - Bizzarri, Marta M.
AU - Ristagno, Giuseppe
AU - Mojoli, Francesco
AU - Pradella, Andrea
AU - Severgnini, Paolo
AU - Da Macallè, Marta
AU - Albertin, Andrea
AU - RANIERI, V. MARCO
AU - Rezoagli, Emanuele
AU - Vitale, Giovanni
AU - Magliocca, Aurora
AU - Cappelleri, Gianluca
AU - Docci, Mattia
AU - Aliberti, Stefano
AU - Serra, Filippo
AU - Rossi, Emanuela
AU - Valsecchi, Maria Grazia
AU - Pesenti, Antonio
AU - Foti, Giuseppe
PY - 2021
DA - 2021/01/04
PB - American Thoracic Society
SP - 1020-1026
IS - 6
VL - 18
PMID - 33395553
SN - 2325-6621
SN - 2329-6933
ER -
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@article{2021_Citerio,
author = {Giuseppe Citerio and Giacomo Grasselli and Maurizio Cecconi and Laura Antolini and Massimo Borelli and Federica De Giacomi and Giancarlo Bosio and Nicola Latronico and Matteo Filippini and Marco Gemma and Claudia Giannotti and Benvenuto Antonini and Nicola Petrucci and Simone Maria Zerbi and Paolo Maniglia and Gian Paolo Castelli and Giovanni Marino and Matteo Subert and Giuseppe Citerio and DANILO RADRIZZANI and Teresa S. Mediani and Ferdinando Luca Lorini and Filippo Maria Russo and Angela Faletti and Andrea Beindorf and Remo Daniel Covello and Stefano Greco and Marta M. Bizzarri and Giuseppe Ristagno and Francesco Mojoli and Andrea Pradella and Paolo Severgnini and Marta Da Macallè and Andrea Albertin and V. MARCO RANIERI and Emanuele Rezoagli and Giovanni Vitale and Aurora Magliocca and Gianluca Cappelleri and Mattia Docci and Stefano Aliberti and Filippo Serra and Emanuela Rossi and Maria Grazia Valsecchi and Antonio Pesenti and Giuseppe Foti and others},
title = {Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID)},
journal = {Annals of the American Thoracic Society},
year = {2021},
volume = {18},
publisher = {American Thoracic Society},
month = {jan},
url = {https://doi.org/10.1513/AnnalsATS.202008-1080OC},
number = {6},
pages = {1020--1026},
doi = {10.1513/AnnalsATS.202008-1080OC}
}
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MLA
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Citerio, Giuseppe, et al. “Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID).” Annals of the American Thoracic Society, vol. 18, no. 6, Jan. 2021, pp. 1020-1026. https://doi.org/10.1513/AnnalsATS.202008-1080OC.