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Acta Pharmaceutica

, том 67 , издание 4 , страницы 495-510

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

Тип публикации: Journal Article

Дата публикации: 2017-12-20

Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society

Acta Pharmaceutica

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SJR: 0.398

CiteScore: 4.5

Impact factor: 1.4

ISSN: 13300075, 18469558

DOI: 10.1515/acph-2017-0040

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PubMed ID: 29337677

General Medicine

Pharmacology

Pharmaceutical Science

Краткое описание

Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. The study showed that the 4,5,6,7 tetrahydrobenzo[ b] thiophene derivatives 6a, 7, 8a,b, 9b and 10b,c w ere t he most active compounds. Their potencies were attributed to the presence of the electron withdrawing groups.

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Mohareb R. M., Abdallah A. E. M., Ahmed E. A. Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile // Acta Pharmaceutica. 2017. Vol. 67. No. 4. pp. 495-510.

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TY - JOUR

DO - 10.1515/acph-2017-0040

UR - https://doi.org/10.1515/acph-2017-0040

TI - Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

T2 - Acta Pharmaceutica

AU - Mohareb, Rafat M.

AU - Abdallah, Amira E. M.

AU - Ahmed, Ebtsam A

PY - 2017

DA - 2017/12/20

PB - Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society

SP - 495-510

IS - 4

VL - 67

PMID - 29337677

SN - 1330-0075

SN - 1846-9558

ER -

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@article{2017_Mohareb,

author = {Rafat M. Mohareb and Amira E. M. Abdallah and Ebtsam A Ahmed},

title = {Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile},

journal = {Acta Pharmaceutica},

year = {2017},

volume = {67},

publisher = {Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society},

month = {dec},

url = {https://doi.org/10.1515/acph-2017-0040},

number = {4},

pages = {495--510},

doi = {10.1515/acph-2017-0040}

}

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Mohareb, Rafat M., et al. “Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile.” Acta Pharmaceutica, vol. 67, no. 4, Dec. 2017, pp. 495-510. https://doi.org/10.1515/acph-2017-0040.