Open Access
Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile
Publication type: Journal Article
Publication date: 2017-12-20
scimago Q2
wos Q4
SJR: 0.398
CiteScore: 4.5
Impact factor: 1.4
ISSN: 13300075, 18469558
PubMed ID:
29337677
General Medicine
Pharmacology
Pharmaceutical Science
Abstract
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. The study showed that the 4,5,6,7 tetrahydrobenzo[ b] thiophene derivatives 6a, 7, 8a,b, 9b and 10b,c w ere t he most active compounds. Their potencies were attributed to the presence of the electron withdrawing groups.
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Mohareb R. M., Abdallah A. E. M., Ahmed E. A. Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile // Acta Pharmaceutica. 2017. Vol. 67. No. 4. pp. 495-510.
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Mohareb R. M., Abdallah A. E. M., Ahmed E. A. Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile // Acta Pharmaceutica. 2017. Vol. 67. No. 4. pp. 495-510.
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TY - JOUR
DO - 10.1515/acph-2017-0040
UR - https://doi.org/10.1515/acph-2017-0040
TI - Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile
T2 - Acta Pharmaceutica
AU - Mohareb, Rafat M.
AU - Abdallah, Amira E. M.
AU - Ahmed, Ebtsam A
PY - 2017
DA - 2017/12/20
PB - Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
SP - 495-510
IS - 4
VL - 67
PMID - 29337677
SN - 1330-0075
SN - 1846-9558
ER -
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@article{2017_Mohareb,
author = {Rafat M. Mohareb and Amira E. M. Abdallah and Ebtsam A Ahmed},
title = {Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile},
journal = {Acta Pharmaceutica},
year = {2017},
volume = {67},
publisher = {Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society},
month = {dec},
url = {https://doi.org/10.1515/acph-2017-0040},
number = {4},
pages = {495--510},
doi = {10.1515/acph-2017-0040}
}
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Mohareb, Rafat M., et al. “Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile.” Acta Pharmaceutica, vol. 67, no. 4, Dec. 2017, pp. 495-510. https://doi.org/10.1515/acph-2017-0040.