Walter de Gruyter
Radiochimica Acta
,  volume 112 ,  issue 3 ,  pages 175-181

Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

Aulia Arivin Billah 1, 2
, 
Kukuh Eka Prasetya 1
, 
Fany Triyatna 1
, 
Daya Agung Sarwono 1
, 
Abidin Abidin 1
, 
Fernanto Rindiyantono 1
, 
Maiyesni Maiyesni 1
, 
Miftakul Munir 1
, 
Indra Saptiama 1
, 
Rien Ritawidya 1, 3
, 
Agustino Zulys 2
1
 
2
 
3
 
Research Collaboration Center for Theranostic Radiopharmaceuticals , Jl. Raya Bandung-Sumedang KM 21 , Sumedang 45363 , Indonesia | 
Publication type: Journal Article
Publication date: 2024-02-06
Walter de Gruyter
scimago Q4
wos Q2
SJR: 0.268
CiteScore: 3.0
Impact factor: 1.7
ISSN: 00338230, 21933405
Physical and Theoretical Chemistry
Abstract

The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

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Billah A. A. et al. Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium // Radiochimica Acta. 2024. Vol. 112. No. 3. pp. 175-181.
GOST all authors (up to 50) Copy
Billah A. A., Prasetya K. E., Triyatna F., Sarwono D. A., Abidin A., Rindiyantono F., Maiyesni M., Munir M., Saptiama I., Ritawidya R., Zulys A. Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium // Radiochimica Acta. 2024. Vol. 112. No. 3. pp. 175-181.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1515/ract-2023-0234
UR - https://doi.org/10.1515/ract-2023-0234
TI - Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium
T2 - Radiochimica Acta
AU - Billah, Aulia Arivin
AU - Prasetya, Kukuh Eka
AU - Triyatna, Fany
AU - Sarwono, Daya Agung
AU - Abidin, Abidin
AU - Rindiyantono, Fernanto
AU - Maiyesni, Maiyesni
AU - Munir, Miftakul
AU - Saptiama, Indra
AU - Ritawidya, Rien
AU - Zulys, Agustino
PY - 2024
DA - 2024/02/06
PB - Walter de Gruyter
SP - 175-181
IS - 3
VL - 112
SN - 0033-8230
SN - 2193-3405
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Billah,
author = {Aulia Arivin Billah and Kukuh Eka Prasetya and Fany Triyatna and Daya Agung Sarwono and Abidin Abidin and Fernanto Rindiyantono and Maiyesni Maiyesni and Miftakul Munir and Indra Saptiama and Rien Ritawidya and Agustino Zulys},
title = {Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium},
journal = {Radiochimica Acta},
year = {2024},
volume = {112},
publisher = {Walter de Gruyter},
month = {feb},
url = {https://doi.org/10.1515/ract-2023-0234},
number = {3},
pages = {175--181},
doi = {10.1515/ract-2023-0234}
}
MLA
Cite this
MLA Copy
Billah, Aulia Arivin, et al. “Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium.” Radiochimica Acta, vol. 112, no. 3, Feb. 2024, pp. 175-181. https://doi.org/10.1515/ract-2023-0234.