Drug Metabolism and Personalized Therapy
Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples.
Dlouha Lucie
1, 2
,
Adamkova Vera
3
,
Šedová Lenka
4
,
Olišarová Věra
4
,
Hubacek Jaroslav A.
1
,
Tóthová Valérie
4
1
Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic
|
3
Department of Preventive Cardiology for Experimental Medicine , Institute for Clinical and Experimental Medicine , Prague , Czech Republic
|
4
Faculty of Health and Social Sciences, University of South Bohemia , České Budejovice , Czech Republic
|
Publication type: Journal Article
Publication date: 2020-06-30
Quartile SCImago
Q2
Quartile WOS
—
Impact factor: —
ISSN: 23638907, 23638915
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Objectives Cytochromes P450 play a role in human drugs metabolic pathways and their genes are among the most variable in humans. The aim of this study was to analyze genotype frequencies of five common polymorphisms of cytochromes P450 in Roma/Gypsy and Czech (non-Roma) population samples with Czech origin. Methods Roma/Gypsy (n=302) and Czech subjects (n=298) were genotyped for CYP1A2 (rs762551), CYP2A6 (rs4105144), CYP2B6 (rs3745274) and CYP2D6 (rs3892097; rs1065852) polymorphisms using PCR-RFLP or Taqman assay. Results We found significant allelic/genotype differences between ethnics in three genes. For rs3745274 polymorphism, there was increased frequency of T allele carriers in Roma in comparison with Czech population (53.1 vs. 43.7%; p=0.02). For rs4105144 (CYP2A6) there was higher frequency of T allele carriers in Roma in comparison with Czech population (68.7 vs. 49.8%; p<0.0001). For rs3892097 (CYP2D6) there was more carriers of the A allele between Roma in comparison with Czech population (39.2 vs. 38.2%; p=0.048). Genotype/allelic frequencies of CYP2D6 (rs1065852) and CYP1A2 (rs762551) variants did not significantly differ between the ethnics. Conclusions There were significant differences in allelic/genotype frequencies of some, but not all cytochromes P450 polymorphisms between the Czech Roma/Gypsies and Czech non-Roma subjects.
Citations by journals
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2
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Journal of Personalized Medicine
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Journal of Personalized Medicine
2 publications, 50%
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ACS Applied Bio Materials
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ACS Applied Bio Materials
1 publication, 25%
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Pharmacogenomics and Personalized Medicine
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Pharmacogenomics and Personalized Medicine
1 publication, 25%
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1
2
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 25%
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Dove Medical Press
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Dove Medical Press
1 publication, 25%
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1
2
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Dlouha L. et al. Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples. // Drug Metabolism and Personalized Therapy. 2020.
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Dlouha L., Adamkova V., Šedová L., Olišarová V., Hubacek J. A., Tóthová V. Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples. // Drug Metabolism and Personalized Therapy. 2020.
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TY - JOUR
DO - 10.1515/dmdi-2020-0103
UR - https://doi.org/10.1515%2Fdmdi-2020-0103
TI - Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples.
T2 - Drug Metabolism and Personalized Therapy
AU - Dlouha, Lucie
AU - Adamkova, Vera
AU - Šedová, Lenka
AU - Olišarová, Věra
AU - Hubacek, Jaroslav A.
AU - Tóthová, Valérie
PY - 2020
DA - 2020/06/30 00:00:00
PB - Walter de Gruyter
SN - 2363-8907
SN - 2363-8915
ER -
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@article{2020_Dlouha,
author = {Lucie Dlouha and Vera Adamkova and Lenka Šedová and Věra Olišarová and Jaroslav A. Hubacek and Valérie Tóthová},
title = {Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples.},
journal = {Drug Metabolism and Personalized Therapy},
year = {2020},
publisher = {Walter de Gruyter},
month = {jun},
url = {https://doi.org/10.1515%2Fdmdi-2020-0103},
doi = {10.1515/dmdi-2020-0103}
}