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Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold
Publication type: Journal Article
Publication date: 2015-11-12
scimago Q3
wos Q3
SJR: 0.292
CiteScore: 3.4
Impact factor: 1.5
ISSN: 07930283, 21910197
Organic Chemistry
Abstract
A new cascade reaction provides a direct transformation of pyrazolin-5-ones and benzylidene-malononitriles by the action of bromine into substituted spirocyclopropylpyrazolones in 60–88% yields. This process can be realized in two variants, namely, (1) by treatment with bromine in the presence of base and (2) by treatment with bromine only with heating. These facile and efficient one-step cascade processes lead to the spirocyclopropylpyrazolone framework, which is present in a perspective class of compounds with prominent pharmacological and physiological activity.
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Vereshchagin A. N. et al. Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold // Heterocyclic Communications. 2015. Vol. 21. No. 6. pp. 355-360.
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Vereshchagin A. N., Elinson M. N., Korshunov A. D., Korolev V. A., Egorov M. P. Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold // Heterocyclic Communications. 2015. Vol. 21. No. 6. pp. 355-360.
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TY - JOUR
DO - 10.1515/hc-2015-0141
UR - https://doi.org/10.1515/hc-2015-0141
TI - Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold
T2 - Heterocyclic Communications
AU - Vereshchagin, Anatoly N.
AU - Elinson, Michail N
AU - Korshunov, Aleksander D
AU - Korolev, Victor A
AU - Egorov, Mikhail P.
PY - 2015
DA - 2015/11/12
PB - Walter de Gruyter
SP - 355-360
IS - 6
VL - 21
SN - 0793-0283
SN - 2191-0197
ER -
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@article{2015_Vereshchagin,
author = {Anatoly N. Vereshchagin and Michail N Elinson and Aleksander D Korshunov and Victor A Korolev and Mikhail P. Egorov},
title = {Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold},
journal = {Heterocyclic Communications},
year = {2015},
volume = {21},
publisher = {Walter de Gruyter},
month = {nov},
url = {https://doi.org/10.1515/hc-2015-0141},
number = {6},
pages = {355--360},
doi = {10.1515/hc-2015-0141}
}
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Vereshchagin, Anatoly N., et al. “Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold.” Heterocyclic Communications, vol. 21, no. 6, Nov. 2015, pp. 355-360. https://doi.org/10.1515/hc-2015-0141.
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