Open Access
5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides
Publication type: Journal Article
Publication date: 2015-09-24
scimago Q3
wos Q3
SJR: 0.292
CiteScore: 3.4
Impact factor: 1.5
ISSN: 07930283, 21910197
Organic Chemistry
Abstract
5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides as well as 5-bromo and 5-iodouracil derivatives were synthesized to evaluate their potential antitumor activity. The halogenated derivatives display no cytotoxicity with respect to all tested cells: KB-3-1 (human epidermoid carcinoma), HeLa (human cervical epithelioid carcinoma), HuTu-80 (human duodenal cancer), B16 (mouse melanoma), and MDCK (normal epithelial). The cytotoxicity of the non-halogenated furano[2,3-d]pyrimidine derivatives increases with the lengthening of the alkyl chain of the substituent from 45 to 60 μm for octyl to from 3 to 10 μm for dodecyl.
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Total citations:
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Matyugina E. S. et al. 5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides // Heterocyclic Communications. 2015. Vol. 21. No. 5. pp. 259-262.
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Matyugina E. S., Logashenko E. B., Zenkova M. A., Kochetkov S. N., Khandazhinskaya A. L. 5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides // Heterocyclic Communications. 2015. Vol. 21. No. 5. pp. 259-262.
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TY - JOUR
DO - 10.1515/hc-2015-0160
UR - https://doi.org/10.1515/hc-2015-0160
TI - 5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides
T2 - Heterocyclic Communications
AU - Matyugina, Elena S
AU - Logashenko, Evgeniya B
AU - Zenkova, Marina A
AU - Kochetkov, Sergey N.
AU - Khandazhinskaya, Anastasia L
PY - 2015
DA - 2015/09/24
PB - Walter de Gruyter
SP - 259-262
IS - 5
VL - 21
SN - 0793-0283
SN - 2191-0197
ER -
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BibTex (up to 50 authors)
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@article{2015_Matyugina,
author = {Elena S Matyugina and Evgeniya B Logashenko and Marina A Zenkova and Sergey N. Kochetkov and Anastasia L Khandazhinskaya},
title = {5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides},
journal = {Heterocyclic Communications},
year = {2015},
volume = {21},
publisher = {Walter de Gruyter},
month = {sep},
url = {https://doi.org/10.1515/hc-2015-0160},
number = {5},
pages = {259--262},
doi = {10.1515/hc-2015-0160}
}
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MLA
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Matyugina, Elena S., et al. “5′-Norcarbocyclic analogues of furano[2,3-d]pyrimidine nucleosides.” Heterocyclic Communications, vol. 21, no. 5, Sep. 2015, pp. 259-262. https://doi.org/10.1515/hc-2015-0160.
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