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Use of anti-amyloid therapies for Alzheimer’s disease in Brazil: a position paper from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Breno J.A.P. Barbosa 1
Elisa de Paula França Resende 2
Raphael Castilhos 3
Wyllians V Borelli 4
Norberto Anizio Ferreira Frota 5
Marcio Luiz Figueredo Balthazar 6
Augusto Celso Scarparo Amato Filho 7
Jerusa Smid 8
Maira Tonidandel Barbosa 9
Artur M. N. Coutinho 10
Leonardo Cruz de Souza 2
Lucas P Schilling 11
Mari N Maia Da Silva 12
Gustavo Bruniera Fernandes 13
P. H. F. Bertolucci 14
Ricardo Nitrini 8
Eliasz Engelhardt 15
Orestes Vicente Forlenza 16
P. Caramelli 2
Sonia Maria Dozzi Brucki 8
Adalberto Studart Neto 8
3
 
Academia Brasileira de Neurologia, Brazil; Hospital de Clínicas de Porto Alegre, Brazil
8
 
Academia Brasileira de Neurologia, Brazil; Universidade de São Paulo, Brazil
11
 
Academia Brasileira de Neurologia, Brazil; Pontifícia Universidade do Rio Grande do Sul, Brazil
12
 
Academia Brasileira de Neurologia, Brazil; Hospital Nina Rodrigues, Brazil
13
 
Hospital Israelita Albert Einstein, Brazil
14
 
Academia Brasileira de Neurologia, Brazil; Universidade Federal de São Paulo, Brazil
Publication typeJournal Article
Publication date2024-11-11
scimago Q3
SJR0.454
CiteScore2.2
Impact factor
ISSN19805764
Abstract

ABSTRACT Novel therapies for Alzheimer’s disease, particularly anti-amyloid drugs like lecanemab and donanemab, have shown modest clinical benefits but also significant risks. The present paper highlights the challenges of access to diagnosis, cost-effectiveness, safety, and the need for more representation of diverse populations in clinical trials. Recommendations include careful patient selection, risk-benefit analysis, and the importance of proven amyloid pathology for treatment. Future work involves further research on anti-amyloid therapies in Brazil and the development of more effective treatments for Alzheimer’s disease.

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Barbosa B. J. et al. Use of anti-amyloid therapies for Alzheimer’s disease in Brazil: a position paper from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology // Dementia e Neuropsychologia. 2024. Vol. 18.
GOST all authors (up to 50) Copy
Barbosa B. J., Resende E. D. P. F., Castilhos R., Borelli W. V., Frota N. A. F., Balthazar M. L. F., Amato Filho A. C. S., Smid J., Barbosa M. T., Coutinho A. M. N., de Souza L. C., Schilling L. P., Maia Da Silva M. N., Fernandes G. B., F. Bertolucci P. H., Nitrini R., Engelhardt E., Forlenza O. V., Caramelli P., Dozzi Brucki S. M., Studart Neto A. Use of anti-amyloid therapies for Alzheimer’s disease in Brazil: a position paper from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology // Dementia e Neuropsychologia. 2024. Vol. 18.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1590/1980-5764-dn-2024-c002
UR - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000101001&tlng=en
TI - Use of anti-amyloid therapies for Alzheimer’s disease in Brazil: a position paper from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology
T2 - Dementia e Neuropsychologia
AU - Barbosa, Breno J.A.P.
AU - Resende, Elisa de Paula França
AU - Castilhos, Raphael
AU - Borelli, Wyllians V
AU - Frota, Norberto Anizio Ferreira
AU - Balthazar, Marcio Luiz Figueredo
AU - Amato Filho, Augusto Celso Scarparo
AU - Smid, Jerusa
AU - Barbosa, Maira Tonidandel
AU - Coutinho, Artur M. N.
AU - de Souza, Leonardo Cruz
AU - Schilling, Lucas P
AU - Maia Da Silva, Mari N
AU - Fernandes, Gustavo Bruniera
AU - F. Bertolucci, P. H.
AU - Nitrini, Ricardo
AU - Engelhardt, Eliasz
AU - Forlenza, Orestes Vicente
AU - Caramelli, P.
AU - Dozzi Brucki, Sonia Maria
AU - Studart Neto, Adalberto
PY - 2024
DA - 2024/11/11
PB - Associacao Neurologia Cognitiva e do Comportamento
VL - 18
PMID - 39534440
SN - 1980-5764
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Barbosa,
author = {Breno J.A.P. Barbosa and Elisa de Paula França Resende and Raphael Castilhos and Wyllians V Borelli and Norberto Anizio Ferreira Frota and Marcio Luiz Figueredo Balthazar and Augusto Celso Scarparo Amato Filho and Jerusa Smid and Maira Tonidandel Barbosa and Artur M. N. Coutinho and Leonardo Cruz de Souza and Lucas P Schilling and Mari N Maia Da Silva and Gustavo Bruniera Fernandes and P. H. F. Bertolucci and Ricardo Nitrini and Eliasz Engelhardt and Orestes Vicente Forlenza and P. Caramelli and Sonia Maria Dozzi Brucki and Adalberto Studart Neto},
title = {Use of anti-amyloid therapies for Alzheimer’s disease in Brazil: a position paper from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology},
journal = {Dementia e Neuropsychologia},
year = {2024},
volume = {18},
publisher = {Associacao Neurologia Cognitiva e do Comportamento},
month = {nov},
url = {http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000101001&tlng=en},
doi = {10.1590/1980-5764-dn-2024-c002}
}