Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo
Publication type: Journal Article
Publication date: 2011-01-01
scimago Q2
wos Q2
SJR: 0.562
CiteScore: 4.3
Impact factor: 2.9
ISSN: 07318898, 21626537
PubMed ID:
21609311
General Medicine
Pathology and Forensic Medicine
Health, Toxicology and Mutagenesis
Toxicology
Abstract
The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and -independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle, and induced apoptosis via activation of caspase 3 and PARP. A single injection of 2 mg/kg body weight of SN-38 caused a significant reduction of lung cancer xenografts. These findings indicate that SN-38 induces apoptosis in the lung cancer cells effectively. Thus, SN-38 can potentially be an effective therapeutic agent against lung cancer.
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24
Total citations:
24
Citations from 2025:
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(12.5%)
The most citing journal
Citations in journal:
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GOST
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Maurya D. K. et al. Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo // Journal of Environmental Pathology, Toxicology and Oncology. 2011. Vol. 30. No. 1. pp. 1-10.
GOST all authors (up to 50)
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Maurya D. K., Ayuzawa R., Doi C., Troyer D., Tamura M. Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo // Journal of Environmental Pathology, Toxicology and Oncology. 2011. Vol. 30. No. 1. pp. 1-10.
Cite this
RIS
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TY - JOUR
DO - 10.1615/jenvironpatholtoxicoloncol.v30.i1.10
UR - https://doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i1.10
TI - Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo
T2 - Journal of Environmental Pathology, Toxicology and Oncology
AU - Maurya, Dharmendra Kumar
AU - Ayuzawa, Rie
AU - Doi, Chiyo
AU - Troyer, Deryl
AU - Tamura, Masaaki
PY - 2011
DA - 2011/01/01
PB - Begell House
SP - 1-10
IS - 1
VL - 30
PMID - 21609311
SN - 0731-8898
SN - 2162-6537
ER -
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BibTex (up to 50 authors)
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@article{2011_Maurya,
author = {Dharmendra Kumar Maurya and Rie Ayuzawa and Chiyo Doi and Deryl Troyer and Masaaki Tamura},
title = {Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo},
journal = {Journal of Environmental Pathology, Toxicology and Oncology},
year = {2011},
volume = {30},
publisher = {Begell House},
month = {jan},
url = {https://doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i1.10},
number = {1},
pages = {1--10},
doi = {10.1615/jenvironpatholtoxicoloncol.v30.i1.10}
}
Cite this
MLA
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Maurya, Dharmendra Kumar, et al. “Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo.” Journal of Environmental Pathology, Toxicology and Oncology, vol. 30, no. 1, Jan. 2011, pp. 1-10. https://doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i1.10.