Role of inflammaging in the development of chronic heart failure and osteoporosis: A literature review

The interaction between heart failure (HF) and osteoporosis in a multimorbid patient is a relevant complication in the aging population. The concept of inflammaging (inflammatory aging) allows us to consider the prolonged process of subclinical inflammation as an adaptation. Depending on the positive or negative influence of inflammaging on the human body, it may induce healthy longevity or aging that is accompanied by geriatric syndromes and various pathologies, including HF and osteoporosis. In this review, we aimed to highlight the issue of inflammaging as a systemic factor in the development of HF and osteoporosis. The function of inflammatory markers, the role of the NLRP3 inflammasome in the immunoinflammatory pathway, and NLRP3’s role in the development of both HF and osteoporosis via the formation of proinflammatory cytokines have been discussed. The influence on different pathogeneses have been considered to determine the development of new therapies.