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Acta Biochimica Polonica
,  том 63 ,  издание 4

Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.

Stawinski J., Boryski J., Barciszewski J., Kraszewski A., Szymanska-Michalak A., Jahnz-Wechmann Z., Wawrzyniak D., Framski G.
Тип публикации: Journal Article
Дата публикации: 2017-03-04
scimago Q3
wos Q4
БС3
SJR: 0.440
CiteScore: 3.4
Impact factor: 1.7
ISSN: 0001527X, 1734154X
Краткое описание
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
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Stawinski J. et al. Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties. // Acta Biochimica Polonica. 2017. Vol. 63. No. 4.
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Stawinski J., Boryski J., Barciszewski J., Kraszewski A., Szymanska-Michalak A., Jahnz-Wechmann Z., Wawrzyniak D., Framski G. Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties. // Acta Biochimica Polonica. 2017. Vol. 63. No. 4.
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TY - JOUR
DO - 10.18388/abp.2016_1338
UR - https://doi.org/10.18388/abp.2016_1338
TI - Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.
T2 - Acta Biochimica Polonica
AU - Stawinski, J
AU - Boryski, J
AU - Barciszewski, J
AU - Kraszewski, A
AU - Szymanska-Michalak, A
AU - Jahnz-Wechmann, Z
AU - Wawrzyniak, D
AU - Framski, G
PY - 2017
DA - 2017/03/04
PB - Polskie Towarzystwo Biochemiczne
IS - 4
VL - 63
PMID - 27830840
SN - 0001-527X
SN - 1734-154X
ER -
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@article{2017_Stawinski,
author = {J Stawinski and J Boryski and J Barciszewski and A Kraszewski and A Szymanska-Michalak and Z Jahnz-Wechmann and D Wawrzyniak and G Framski},
title = {Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.},
journal = {Acta Biochimica Polonica},
year = {2017},
volume = {63},
publisher = {Polskie Towarzystwo Biochemiczne},
month = {mar},
url = {https://doi.org/10.18388/abp.2016_1338},
number = {4},
doi = {10.18388/abp.2016_1338}
}