Open Access
International Journal of Reproductive BioMedicine, pages 741-750
Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study
Ziba Akbari
1
,
Roghayeh Taghipour Dijojin
1, 2
,
Zahra Zamani
1
,
Reza Hajihosseini
2
,
Mohammad Arjmand
1
1
Biochemistry Department, Metabolomics Lab, Pasture Institute of Iran, Tehran, Iran.
|
Publication type: Journal Article
Publication date: 2021-09-09
Quartile SCImago
Q3
Quartile WOS
—
Impact factor: 1.2
ISSN: 24764108, 24763772
Reproductive Medicine
Obstetrics and Gynecology
Abstract
Background: Prostate cancer (PCa) is a common health problem worldwide. The rate of this disease is likely to grow by 2021. PCa is a heterogeneous disorder, and various biochemical factors contribute to the development of this disease. The metabolome is the complete set of metabolites in a cell or biological sample and represents the downstream end product of the omics. Hence, to model PCa by computational systems biology, a preliminary metabolomics-based study was used to compare the metabolome profile pattern between healthy and PCa men. Objective: This study was carried out to highlight energy metabolism modification and assist the prognosis and treatment of disease with unique biomarkers. Materials and Methods: In this cross-sectional research, 26 men diagnosed with stage-III PCa and 26 healthy men with normal PSA levels were enrolled. Urine was analyzed with proton nuclear magnetic resonance (1H-NMR) spectroscopy, accompanied by the MetaboAnalyst web-based platform tool for metabolomics data analysis. Partial least squares regression discriminant analysis was applied to clarify the separation between the two groups. Outliers were documented and metabolites determined, followed by identifying biochemical pathways. Results: Our findings reveal that modifications in aromatic amino acid metabolism and some of their metabolites have a high potential for use as urinary PCa biomarkers. Tryptophan metabolism (p < 0.001), tyrosine metabolism (p < 0.001), phenylalanine, tyrosine and tryptophan biosynthesis (p < 0.001), phenylalanine metabolism (p = 0.01), ubiquinone and other terpenoid-quinone biosynthesis (p = 0.19), nitrogen metabolism (p = 0.21), and thiamine metabolism (p = 0.41) with Q2 (0.198) and R2 (0.583) were significantly altered. Conclusion: The discriminated metabolites and their pathways play an essential role in PCa causes and harmony. Key words: Metabolomics, Prostate cancer, Aromatic amino acids, 1H-NMR spectroscopy.
Top-30
Citations by journals
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1
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Proteomes
1 publication, 20%
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Archiv der Pharmazie
1 publication, 20%
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Analytica Chimica Acta
1 publication, 20%
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Russian Chemical Reviews
1 publication, 20%
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Expert Review of Proteomics
1 publication, 20%
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1
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 20%
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Wiley
1 publication, 20%
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Elsevier
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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Taylor & Francis
1 publication, 20%
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1
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Akbari Z. et al. Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study // International Journal of Reproductive BioMedicine. 2021. pp. 741-750.
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Akbari Z., Taghipour Dijojin R., Zamani Z., Hajihosseini R., Arjmand M. Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study // International Journal of Reproductive BioMedicine. 2021. pp. 741-750.
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TY - JOUR
DO - 10.18502/ijrm.v19i8.9622
UR - https://knepublishing.com/index.php/ijrm/article/view/9622
TI - Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study
T2 - International Journal of Reproductive BioMedicine
AU - Akbari, Ziba
AU - Taghipour Dijojin, Roghayeh
AU - Zamani, Zahra
AU - Hajihosseini, Reza
AU - Arjmand, Mohammad
PY - 2021
DA - 2021/09/09 00:00:00
PB - Knowledge E DMCC
SP - 741-750
SN - 2476-4108
SN - 2476-3772
ER -
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@article{2021_Akbari,
author = {Ziba Akbari and Roghayeh Taghipour Dijojin and Zahra Zamani and Reza Hajihosseini and Mohammad Arjmand},
title = {Aromatic amino acids play a harmonizing role in prostate cancer: A metabolomics-based cross-sectional study},
journal = {International Journal of Reproductive BioMedicine},
year = {2021},
publisher = {Knowledge E DMCC},
month = {sep},
url = {https://knepublishing.com/index.php/ijrm/article/view/9622},
pages = {741--750},
doi = {10.18502/ijrm.v19i8.9622}
}