Open Access
Quantitative Imaging in Medicine and Surgery, volume 10, issue 7, pages 1441-1449
Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla
Publication type: Journal Article
Publication date: 2020-07-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 22234292, 22234306
PubMed ID:
32676363
Radiology Nuclear Medicine and imaging
Abstract
Fast single-point macromolecular proton fraction (MPF) mapping is a recent magnetic resonance imaging (MRI) method enabling quantitative assessment of myelin content in neural tissues. To date, the reported technical implementations of MPF mapping utilized high-field MRI equipment (1.5 T or higher), while low-field applications might pose challenges due to signal-to-noise ratio (SNR) limitations and short T1 . This study aimed to evaluate the feasibility of MPF mapping of the human brain at 0.5 T. The three-dimensional MPF mapping protocol was implemented according to the single-point synthetic-reference method, which includes three spoiled gradient-echo sequences providing proton density, T1 , and magnetization transfer contrast weightings. Whole-brain MPF maps were obtained from three healthy volunteers with spatial resolution of 1.5×1.5×2 mm3 and the total scan time of 19 minutes. MPF values were measured in a series of white and gray matter structures and compared with literature data for 3 T magnetic field. MPF maps enabled high contrast between white and gray matter with notable insensitivity to paramagnetic effects in iron-rich structures, such as globus pallidus, substantia nigra, and dentate nucleus. MPF values at 0.5 T appeared in close agreement with those at 3 T. This study demonstrates the feasibility of fast MPF mapping with low-field MRI equipment and the independence of brain MPF values of magnetic field. The presented results confirm the utility of MPF as an absolute scale for MRI-based myelin content measurements across a wide range of magnetic field strengths and extend the applicability of fast MPF mapping to inexpensive low-field MRI hardware.
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Anisimov A. et al. Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla // Quantitative Imaging in Medicine and Surgery. 2020. Vol. 10. No. 7. pp. 1441-1449.
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Anisimov A., O. Pavlova O. P., Pirogov Y. A., Yarnykh V. L. Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla // Quantitative Imaging in Medicine and Surgery. 2020. Vol. 10. No. 7. pp. 1441-1449.
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TY - JOUR
DO - 10.21037/QIMS-19-1057
UR - https://doi.org/10.21037%2FQIMS-19-1057
TI - Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla
T2 - Quantitative Imaging in Medicine and Surgery
AU - Anisimov, Alexander
AU - O. Pavlova, O. Pavlova
AU - Pirogov, Yury A.
AU - Yarnykh, Vasily L.
PY - 2020
DA - 2020/07/01 00:00:00
PB - AME Publishing Company
SP - 1441-1449
IS - 7
VL - 10
PMID - 32676363
SN - 2223-4292
SN - 2223-4306
ER -
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@article{2020_Anisimov,
author = {Alexander Anisimov and O. Pavlova O. Pavlova and Yury A. Pirogov and Vasily L. Yarnykh},
title = {Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla},
journal = {Quantitative Imaging in Medicine and Surgery},
year = {2020},
volume = {10},
publisher = {AME Publishing Company},
month = {jul},
url = {https://doi.org/10.21037%2FQIMS-19-1057},
number = {7},
pages = {1441--1449},
doi = {10.21037/QIMS-19-1057}
}
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MLA
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Anisimov, Alexander, et al. “Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla.” Quantitative Imaging in Medicine and Surgery, vol. 10, no. 7, Jul. 2020, pp. 1441-1449. https://doi.org/10.21037%2FQIMS-19-1057.
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