Open Access
Cancer Management and Research, volume Volume 10, pages 3141-3148
Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis
Publication type: Journal Article
Publication date: 2018-08-30
Journal:
Cancer Management and Research
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.3
ISSN: 11791322
PubMed ID:
30214306
Oncology
Abstract
Objective To explore the relationship between single-nucleotide polymorphisms (SNPs) in one of the long noncoding RNA (lncRNA), cancer susceptibility candidate 8 (CASC8) gene and the risk of cancer. Materials and methods A meta-analysis was conducted to summarize the relationship between common SNPs (rs10505477 and rs7837328) in the lncRNA CASC8 gene and the risk of cancer. The relevant references were retrieved from several authoritative databases. Rigorous inclusion and exclusion criteria were adopted to ensure the credibility of the results. The fixed effects or random effects model was used to calculate the OR and 95% CI. We tested for publication bias. Results Fifteen articles containing 20 datasets (24,504 cases and 22,969 controls) were finally included in the meta-analysis. Compared to the individuals carrying the rs10505477 TT genotype, those with the TC or CC genotype had a decreased risk of cancer (TC vs TT: OR 0.876, 95% CI 0.832–0.923, P<0.001; CC vs TT: OR 0.748, 95% CI 0.703–0.795, P<0.001). Allele C of rs10505477 might be a protective factor for decreasing susceptibility to cancer (OR 0.866, 95% CI 0.840–0.893, P<0.001). As for rs7837328, the GA and AA genotypes were associated with increased risks of cancer as compared to the GG genotype (ORs 1.209 and 1.336; 95% CIs 1.127–1.298 and 1.202–1.484, respectively); its A allele could significantly increase the risk of cancer compared with the G allele (OR 1.169, 95% CI 1.114–1.227, P<0.001). Conclusion The rs10505477 and rs7837328 polymorphisms might be associated with risk of cancer.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Cui Z. et al. Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis // Cancer Management and Research. 2018. Vol. Volume 10. pp. 3141-3148.
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Cui Z., Gao M., Gao M., Yin Z., Yan L., Cui L. Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis // Cancer Management and Research. 2018. Vol. Volume 10. pp. 3141-3148.
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TY - JOUR
DO - 10.2147/CMAR.S170783
UR - https://doi.org/10.2147%2FCMAR.S170783
TI - Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis
T2 - Cancer Management and Research
AU - Cui, Zhigang
AU - Gao, Min
AU - Yin, Zhihua
AU - Cui, Lei
AU - Gao, Min
AU - Yan, Lei
PY - 2018
DA - 2018/08/30 00:00:00
PB - Dove Medical Press
SP - 3141-3148
VL - Volume 10
PMID - 30214306
SN - 1179-1322
ER -
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@article{2018_Cui,
author = {Zhigang Cui and Min Gao and Zhihua Yin and Lei Cui and Min Gao and Lei Yan},
title = {Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis},
journal = {Cancer Management and Research},
year = {2018},
volume = {Volume 10},
publisher = {Dove Medical Press},
month = {aug},
url = {https://doi.org/10.2147%2FCMAR.S170783},
pages = {3141--3148},
doi = {10.2147/CMAR.S170783}
}