Open Access
Cancer Management and Research, volume Volume 12, pages 13461-13467
CASC8 lncRNA Promotes the Proliferation of Retinoblastoma Cells Through Downregulating miR34a Methylation
1
Department of Ophthalmology, Shenzhen Hospital of Integrated Chinese and Western Medicine, Shenzhen 518101, Guangdong Province, People's Republic of China.
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Publication type: Journal Article
Publication date: 2020-12-29
Journal:
Cancer Management and Research
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.3
ISSN: 11791322
PubMed ID:
33408518
Oncology
Abstract
Background CASC8 lncRNA has been proven to be oncogenic in a variety of cancers, but its role in other types of cancer remains unclear. This study was to investigate the role of CASC8 in retinoblastoma (Rb). Methods RT-qPCR was performed to determine the expression of CASC8 and miR34a in paired Rb and nontumor tissue. Overexpression of CASC8 and miR34a in Rb cells was achieved to evaluate the interaction between them. Methylation-specific PCR was used to analyze the effect of CASC8 overexpression on MIR34A gene methylation. CCK8 assays were used to analyze cell proliferation. Results The results showed that CASC8 expression was upregulated and miR34a expression downregulated in Rb tissue. Moreover, miR34a expression was negatively correlated with the of CASC8 expression in Rb tissue. Overexpression of CASC8 decreased expression of miR34a and increased methylation of MIR34A in Rb cells. In addition, overexpression of CASC8 reduced the inhibitory effects of miR34a on Rb-cell proliferation. Conclusion CASC8 may promote Rb cell proliferation by downregulating miR34a methylation.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yang B. et al. CASC8 lncRNA Promotes the Proliferation of Retinoblastoma Cells Through Downregulating miR34a Methylation // Cancer Management and Research. 2020. Vol. Volume 12. pp. 13461-13467.
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Yang B., Gu B., Zhang J., Xu L., Sun Y. CASC8 lncRNA Promotes the Proliferation of Retinoblastoma Cells Through Downregulating miR34a Methylation // Cancer Management and Research. 2020. Vol. Volume 12. pp. 13461-13467.
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TY - JOUR
DO - 10.2147/CMAR.S268380
UR - https://doi.org/10.2147%2FCMAR.S268380
TI - CASC8 lncRNA Promotes the Proliferation of Retinoblastoma Cells Through Downregulating miR34a Methylation
T2 - Cancer Management and Research
AU - Yang, Bo
AU - Gu, Baoyu
AU - Zhang, Jing
AU - Xu, Long
AU - Sun, Yong
PY - 2020
DA - 2020/12/29 00:00:00
PB - Dove Medical Press
SP - 13461-13467
VL - Volume 12
PMID - 33408518
SN - 1179-1322
ER -
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@article{2020_Yang,
author = {Bo Yang and Baoyu Gu and Jing Zhang and Long Xu and Yong Sun},
title = {CASC8 lncRNA Promotes the Proliferation of Retinoblastoma Cells Through Downregulating miR34a Methylation},
journal = {Cancer Management and Research},
year = {2020},
volume = {Volume 12},
publisher = {Dove Medical Press},
month = {dec},
url = {https://doi.org/10.2147%2FCMAR.S268380},
pages = {13461--13467},
doi = {10.2147/CMAR.S268380}
}