Open Access

International Journal of Nanomedicine, volume Volume 13, pages 439-453

Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo

Deng Wentao

QIU JUHUI

Wang Shaoting

Yuan Zhi

Jia Yuefeng

TAN HAILIN

Lu Jiru

Zheng Ruqiang

Publication type: Journal Article

Publication date: 2018-01-16

Dove Medical Press

Journal: International Journal of Nanomedicine

Quartile SCImago

Quartile WOS

Impact factor: 8

ISSN: 11769114, 11782013

DOI: 10.2147/IJN.S150977

Copy DOI

PubMed ID: 29403275

Organic Chemistry

Drug Discovery

General Medicine

Biophysics

Pharmaceutical Science

Bioengineering

Biomaterials

Abstract

In this study, we performed the characterization and synthesis of biocompatible and targeted albumin and graphene oxide (GO) dual-carrier paclitaxel (PTX) nanoparticles for photothermal-triggered tumor therapy. PTX absorbed on GO nanosheets as cores were coated with human serum albumin (HSA), following surface conjugation with monoclonal antibodies (mAb) against vascular endothelial growth factor (VEGF; denoted as mAbVEGF) via polyethylene glycol linker to form targeted nanoparticles (PTX-GHP-VEGF). The spherical nanoparticles were 191±5 nm in size with good stability and biocompatibility. GO functioned as the first carrier and a near infrared absorber that can generate photothermal effects under 5-minute 808-nm laser irradiation to thermal trigger the release of PTX from the second carrier HSA nanoparticles. The mechanism of thermal-triggered drug release was also investigated preliminarily, in which the heat generated by GO induced swelling of PTX-GHP-VEGF nanoparticles which released the drugs. In vitro studies found that PTX-GHP-VEGF can efficiently target human SW-13 adrenocortical carcinoma cells as evaluated by confocal fluorescence microscopy as well as transmission electron microscopy, and showed an obvious thermal-triggered antitumor effect, mediated by apoptosis. Moreover, PTX-GHP-VEGF combined with near infrared irradiation showed specific tumor suppression effects with high survival rate after 100 days of treatment. PTX-GHP-VEGF also demonstrated high biosafety with no adverse effects on normal tissues and organs. These results highlight the remarkable potential of PTX-GHP-VEGF in photothermal controllable tumor treatment.

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Citations by journals

	1 2 3
Journal of Controlled Release	Journal of Controlled Release, 3, 6.98% Journal of Controlled Release 3 publications, 6.98%
Nanoscale Research Letters	Nanoscale Research Letters, 2, 4.65% Nanoscale Research Letters 2 publications, 4.65%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 2, 4.65% International Journal of Pharmaceutics 2 publications, 4.65%
Journal of Drug Targeting	Journal of Drug Targeting, 2, 4.65% Journal of Drug Targeting 2 publications, 4.65%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 4.65% International Journal of Nanomedicine 2 publications, 4.65%
Pharmaceutical Chemistry Journal	Pharmaceutical Chemistry Journal, 1, 2.33% Pharmaceutical Chemistry Journal 1 publication, 2.33%
ACS Materials Letters	ACS Materials Letters, 1, 2.33% ACS Materials Letters 1 publication, 2.33%
Mini-Reviews in Organic Chemistry	Mini-Reviews in Organic Chemistry, 1, 2.33% Mini-Reviews in Organic Chemistry 1 publication, 2.33%
Current Medicinal Chemistry	Current Medicinal Chemistry, 1, 2.33% Current Medicinal Chemistry 1 publication, 2.33%
Nanomedicine	Nanomedicine, 1, 2.33% Nanomedicine 1 publication, 2.33%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.33% International Journal of Molecular Sciences 1 publication, 2.33%
Pharmaceutics	Pharmaceutics, 1, 2.33% Pharmaceutics 1 publication, 2.33%
Frontiers in Nanotechnology	Frontiers in Nanotechnology, 1, 2.33% Frontiers in Nanotechnology 1 publication, 2.33%
Pharmaceutical Research	Pharmaceutical Research, 1, 2.33% Pharmaceutical Research 1 publication, 2.33%
Photodiagnosis and Photodynamic Therapy	Photodiagnosis and Photodynamic Therapy, 1, 2.33% Photodiagnosis and Photodynamic Therapy 1 publication, 2.33%
Materials Today Communications	Materials Today Communications, 1, 2.33% Materials Today Communications 1 publication, 2.33%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 2.33% Colloids and Surfaces B: Biointerfaces 1 publication, 2.33%
Particle and Particle Systems Characterization	Particle and Particle Systems Characterization, 1, 2.33% Particle and Particle Systems Characterization 1 publication, 2.33%
ChemistrySelect	ChemistrySelect, 1, 2.33% ChemistrySelect 1 publication, 2.33%
ACS Omega	ACS Omega, 1, 2.33% ACS Omega 1 publication, 2.33%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 2.33% ACS applied materials & interfaces 1 publication, 2.33%
Chemical Science	Chemical Science, 1, 2.33% Chemical Science 1 publication, 2.33%
Biomaterials Science	Biomaterials Science, 1, 2.33% Biomaterials Science 1 publication, 2.33%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 2.33% Journal of Materials Chemistry B 1 publication, 2.33%
Environmental Science: Nano	Environmental Science: Nano, 1, 2.33% Environmental Science: Nano 1 publication, 2.33%
Nanoscale Advances	Nanoscale Advances, 1, 2.33% Nanoscale Advances 1 publication, 2.33%
Spectroscopy Letters	Spectroscopy Letters, 1, 2.33% Spectroscopy Letters 1 publication, 2.33%
Drug Delivery	Drug Delivery, 1, 2.33% Drug Delivery 1 publication, 2.33%
Expert Opinion on Drug Delivery	Expert Opinion on Drug Delivery, 1, 2.33% Expert Opinion on Drug Delivery 1 publication, 2.33%
	1 2 3

Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 18.6% Elsevier 8 publications, 18.6%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 5, 11.63% Royal Society of Chemistry (RSC) 5 publications, 11.63%
Taylor & Francis	Taylor & Francis, 5, 11.63% Taylor & Francis 5 publications, 11.63%
Springer Nature	Springer Nature, 4, 9.3% Springer Nature 4 publications, 9.3%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 6.98% American Chemical Society (ACS) 3 publications, 6.98%
Hindawi Limited	Hindawi Limited, 3, 6.98% Hindawi Limited 3 publications, 6.98%
Bentham Science	Bentham Science, 2, 4.65% Bentham Science 2 publications, 4.65%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 4.65% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 4.65%
Wiley	Wiley, 2, 4.65% Wiley 2 publications, 4.65%
Dove Medical Press	Dove Medical Press, 2, 4.65% Dove Medical Press 2 publications, 4.65%
Future Medicine	Future Medicine, 1, 2.33% Future Medicine 1 publication, 2.33%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.33% Frontiers Media S.A. 1 publication, 2.33%
	1 2 3 4 5 6 7 8

We do not take into account publications that without a DOI.
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Deng W. et al. Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo // International Journal of Nanomedicine. 2018. Vol. Volume 13. pp. 439-453.

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Deng W., QIU J., Wang S., Yuan Z., Jia Y., TAN H., Lu J., Zheng R. Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo // International Journal of Nanomedicine. 2018. Vol. Volume 13. pp. 439-453.

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RIS Copy

TY - JOUR

DO - 10.2147/IJN.S150977

UR - https://doi.org/10.2147%2FIJN.S150977

TI - Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo

T2 - International Journal of Nanomedicine

AU - Deng, Wentao

AU - QIU, JUHUI

AU - Wang, Shaoting

AU - Yuan, Zhi

AU - Jia, Yuefeng

AU - TAN, HAILIN

AU - Lu, Jiru

AU - Zheng, Ruqiang

PY - 2018

DA - 2018/01/16 00:00:00

PB - Dove Medical Press

SP - 439-453

VL - Volume 13

PMID - 29403275

SN - 1176-9114

SN - 1178-2013

ER -

BibTex

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BibTex Copy

@article{2018_Deng,

author = {Wentao Deng and JUHUI QIU and Shaoting Wang and Zhi Yuan and Yuefeng Jia and HAILIN TAN and Jiru Lu and Ruqiang Zheng},

title = {Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo},

journal = {International Journal of Nanomedicine},

year = {2018},

volume = {Volume 13},

publisher = {Dove Medical Press},

month = {jan},

url = {https://doi.org/10.2147%2FIJN.S150977},

pages = {439--453},

doi = {10.2147/IJN.S150977}

}

Found error?

Publisher

Dove Medical Press

Journal

International Journal of Nanomedicine

Quartile SCImago

Quartile WOS

Impact factor

ISSN

11769114 (Print)
11782013 (Electronic)