Bentham Science Publishers Ltd.
Protein and Peptide Letters
,  том 32 ,  издание 3 ,  страницы 171-182

miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression

Xin Li 1, 2, 3
, 
Jie Liu 4, 5
, 
Lili He 1
, 
Mi Tian 6, 7
, 
YINGYING XU 1
, 
Bing Peng 8, 9
1
 
Department of Thyroid and Breast, Jingmen City People's Hospital, Jingmen, Hubei, P.R. China | 
2
 
3
 
4
 
Pathology Department of Jingmen People's Hospital, Hubei Province, China | 
5
 
Department of Pathology, Jingmen People's Hospital, Hubei Province, Jingmen, China | 
6
 
Forensic Appraisal Center of Jingmen Public Security Bureau Jingmen 448000, Hubei Province, China | 
7
 
Forensic Appraisal Center of Jingmen Public Security Bureau, Jingmen People's Hospital, Jingmen 448000, Hubei Province, China | 
8
 
Department of Oncology, Jingmen People's Hospital, Hubei Province, China | 
9
 
Department of Oncology, Jingmen People's Hospital, Hubei Province, Jingmen, China | 
Тип публикации: Journal Article
Дата публикации: 2025-03-01
Bentham Science Publishers Ltd.
scimago Q3
wos Q4
БС3
SJR: 0.338
CiteScore: 2.4
Impact factor: 1.1
ISSN: 09298665, 18755305
Краткое описание
Introduction:

Endogenous microRNAs (miRNAs) are critical regulators of tumor progression, making their role in breast cancer an important area of investigation.

Method:

This study examined the regulation of MSMO1 by miR-584-5p in breast cancer cells. Using bioinformatics and Western blotting, we confirmed MSMO1 expression in breast cancer cells and evaluated its effects on cell migration, invasion, and the AKT signaling pathway. In vivo experiments further supported these findings. The interaction between miR-584-5p and MSMO1 was validated through luciferase reporter assays, while functional studies highlighted the impact of miR-584-5p on cancer progression.

objective:

study sought to elucidate the molecular underpinnings of miR-584-5p-mediated regulation of MSMO1 in breast cancer

Result:

Our findings revealed that MSMO1 is upregulated in breast cancer, enhancing cell migration and invasion. Silencing MSMO1 diminished AKT pathway activity, and luciferase assays confirmed MSMO1 as a direct target of miR-584-5p.

Conclusion:

Overexpression of miR-584-5p suppressed migration and invasion of breast cancer cells. In summary, miR-584-5p is likely to modulate MSMO1 and subsequently regulate the AKT/ PI3K pathway, presenting a promising therapeutic target for breast cancer treatment.

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Li X. et al. miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression // Protein and Peptide Letters. 2025. Vol. 32. No. 3. pp. 171-182.
ГОСТ со всеми авторами (до 50) Скопировать
Li X., Liu J., He L., Tian M., XU Y., Peng B. miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression // Protein and Peptide Letters. 2025. Vol. 32. No. 3. pp. 171-182.
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TY - JOUR
DO - 10.2174/0109298665339026250114070523
UR - https://www.eurekaselect.com/239408/article
TI - miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression
T2 - Protein and Peptide Letters
AU - Li, Xin
AU - Liu, Jie
AU - He, Lili
AU - Tian, Mi
AU - XU, YINGYING
AU - Peng, Bing
PY - 2025
DA - 2025/03/01
PB - Bentham Science Publishers Ltd.
SP - 171-182
IS - 3
VL - 32
SN - 0929-8665
SN - 1875-5305
ER -
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@article{2025_Li,
author = {Xin Li and Jie Liu and Lili He and Mi Tian and YINGYING XU and Bing Peng},
title = {miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression},
journal = {Protein and Peptide Letters},
year = {2025},
volume = {32},
publisher = {Bentham Science Publishers Ltd.},
month = {mar},
url = {https://www.eurekaselect.com/239408/article},
number = {3},
pages = {171--182},
doi = {10.2174/0109298665339026250114070523}
}
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Li, Xin, et al. “miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression.” Protein and Peptide Letters, vol. 32, no. 3, Mar. 2025, pp. 171-182. https://www.eurekaselect.com/239408/article.