Bentham Science Publishers Ltd.
Combinatorial Chemistry and High Throughput Screening
,  volume 27 ,  issue 4 ,  pages 561-581

Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance

Publication type: Journal Article
Publication date: 2025-02-01
Bentham Science Publishers Ltd.
scimago Q3
wos Q3
SJR: 0.361
CiteScore: 3.5
Impact factor: 1.7
ISSN: 13862073, 18755402
Abstract
Abstract:

Chemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug resistance mechanisms and summarizes relevant anti-resistance drugs. In addition, due to the therapeutic limitations of the aforementioned treatments, new advances in nanocarrier-based combination immunotherapy to address the challenge of drug resistance have been described. Nanocarriers combined with immunotherapy can not only target tumor sites for targeted drug release but also modulate the autoimmune system and enhance immune efficacy, thereby overcoming tumor drug resistance. This review suggests new strategies for overcoming tumor drug resistance and is expected to inform tumor treatment and prognosis.

Found 

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
0
Share
Cite this
GOST |
Cite this
GOST Copy
Liu Y. et al. Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance // Combinatorial Chemistry and High Throughput Screening. 2025. Vol. 27. No. 4. pp. 561-581.
GOST all authors (up to 50) Copy
Liu Y., Sun X., Wei Chen, Guo S., Song C., Zhang J., Bai J. Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance // Combinatorial Chemistry and High Throughput Screening. 2025. Vol. 27. No. 4. pp. 561-581.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.2174/0113862073296206240416060154
UR - https://www.eurekaselect.com/229323/article
TI - Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
T2 - Combinatorial Chemistry and High Throughput Screening
AU - Liu, Yun
AU - Sun, Xinyu
AU - Wei Chen
AU - Guo, Shoudong
AU - Song, Chunxiao
AU - Zhang, Jiangyu
AU - Bai, Jingkun
PY - 2025
DA - 2025/02/01
PB - Bentham Science Publishers Ltd.
SP - 561-581
IS - 4
VL - 27
PMID - 38676501
SN - 1386-2073
SN - 1875-5402
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Liu,
author = {Yun Liu and Xinyu Sun and Wei Chen and Shoudong Guo and Chunxiao Song and Jiangyu Zhang and Jingkun Bai},
title = {Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance},
journal = {Combinatorial Chemistry and High Throughput Screening},
year = {2025},
volume = {27},
publisher = {Bentham Science Publishers Ltd.},
month = {feb},
url = {https://www.eurekaselect.com/229323/article},
number = {4},
pages = {561--581},
doi = {10.2174/0113862073296206240416060154}
}
MLA
Cite this
MLA Copy
Liu, Yun, et al. “Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance.” Combinatorial Chemistry and High Throughput Screening, vol. 27, no. 4, Feb. 2025, pp. 561-581. https://www.eurekaselect.com/229323/article.