Bentham Science Publishers Ltd.
Combinatorial Chemistry and High Throughput Screening
,  volume 26 ,  issue 6 ,  pages 1108-1140

L-Proline: A Versatile Organo-Catalyst in Organic Chemistry

Bapu R Thorat 1
, 
Suraj N. Mali 2
, 
Swati S. Wavhal 3
, 
Devidas S. Bhagat 4
, 
Ravikumar M. Borade 4
, 
A. Chapolikar 1
, 
Ajaykumar Gandhi 1
, 
Pawan Shinde 1
1
 
Government of Maharashtra, Government College of Arts and Science, Aurangabad 431001 (MS), India | 
2
 
3
 
Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai 410060 (MS), India | 
4
 
Department of Chemistry, Government Institute of Forensic Science, Aurangabad 431 004, (MS), India | 
Publication type: Journal Article
Publication date: 2023-05-01
Bentham Science Publishers Ltd.
scimago Q3
wos Q3
SJR: 0.361
CiteScore: 3.5
Impact factor: 1.7
ISSN: 13862073, 18755402
Organic Chemistry
Drug Discovery
Computer Science Applications
General Medicine
Abstract
Background:

L-proline is a natural amino acid having secondary amine functionality and acts as a bifunctional catalyst (organo-catalyst). The amino-functional group acts as Lewis base type while carboxylic acids act as Brønsted acid type catalysts. It catalyzed different asymmetric syntheses, including known reactions such as Aldol condensation, Mannich reaction, Michael Addition, Knoevenagel condensation, Hantzsch synthesis, OXA-Michael Henry tandem, Ullmann reactions, Wieland-Miescher ketone synthesis, Robinson annulation, Biginelli reaction, α- amination. It is also an essential catalyst for synthesizing heterocyclic skeletons such as coumarin, spiro-oxindoles, imidazoles, benzimidazoles, quinoxalines, podophyllotoxin, benzothiazoles, isoxazolidines, phenothiazines, aziridine, indole, 1,5-benzodiazepines, pyridine, and quinazolines.

Objective:

In this review, we had the objective to critically summarize the use of proline and proline derivatives as catalysts of multicomponent reactions performed in various media and leading to synthetically and biologically relevant heterocycles, a very important class of compounds that constitutes over 60% of drugs and agrochemicals.

Methods:

All scholarly articles for L-Proline catalyzed reactions were retrieved from ScienceDirect, Google Scholar , PubMed, etc.

Results and Conclusion:

Given the importance of L-Proline based reactions, it has been observed to have tremendous applications in organic chemistry. It can also act as a 'Green catalyst'.

Found 
Found 

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Thorat B. R. et al. L-Proline: A Versatile Organo-Catalyst in Organic Chemistry // Combinatorial Chemistry and High Throughput Screening. 2023. Vol. 26. No. 6. pp. 1108-1140.
GOST all authors (up to 50) Copy
Thorat B. R., Mali S. N., Wavhal S. S., Bhagat D. S., Borade R. M., Chapolikar A., Gandhi A., Shinde P. L-Proline: A Versatile Organo-Catalyst in Organic Chemistry // Combinatorial Chemistry and High Throughput Screening. 2023. Vol. 26. No. 6. pp. 1108-1140.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.2174/1386207325666220720105845
UR - https://doi.org/10.2174/1386207325666220720105845
TI - L-Proline: A Versatile Organo-Catalyst in Organic Chemistry
T2 - Combinatorial Chemistry and High Throughput Screening
AU - Thorat, Bapu R
AU - Mali, Suraj N.
AU - Wavhal, Swati S.
AU - Bhagat, Devidas S.
AU - Borade, Ravikumar M.
AU - Chapolikar, A.
AU - Gandhi, Ajaykumar
AU - Shinde, Pawan
PY - 2023
DA - 2023/05/01
PB - Bentham Science Publishers Ltd.
SP - 1108-1140
IS - 6
VL - 26
PMID - 35864793
SN - 1386-2073
SN - 1875-5402
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Thorat,
author = {Bapu R Thorat and Suraj N. Mali and Swati S. Wavhal and Devidas S. Bhagat and Ravikumar M. Borade and A. Chapolikar and Ajaykumar Gandhi and Pawan Shinde},
title = {L-Proline: A Versatile Organo-Catalyst in Organic Chemistry},
journal = {Combinatorial Chemistry and High Throughput Screening},
year = {2023},
volume = {26},
publisher = {Bentham Science Publishers Ltd.},
month = {may},
url = {https://doi.org/10.2174/1386207325666220720105845},
number = {6},
pages = {1108--1140},
doi = {10.2174/1386207325666220720105845}
}
MLA
Cite this
MLA Copy
Thorat, Bapu R., et al. “L-Proline: A Versatile Organo-Catalyst in Organic Chemistry.” Combinatorial Chemistry and High Throughput Screening, vol. 26, no. 6, May. 2023, pp. 1108-1140. https://doi.org/10.2174/1386207325666220720105845.