Bentham Science Publishers Ltd.
Combinatorial Chemistry and High Throughput Screening
,  volume 27 ,  issue 14 ,  pages 2101-2109

Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2

Jian-Kun Cui 1, 2
, 
Mingming Fan 3, 4
, 
Wang Qinwen 5, 6
1
 
2
 
3
 
Nangang Branch of Heilongjiang Academy of Traditional Chinese Medicine, No.33 Westdazhi Street, Harbin 150006, Heilongjiang, China | 
4
 
Nangang Branch of Heilongjiang Academy of Traditional Chinese Medicine, No.33 Westdazhi Street, Harbin, Heilongjiang, 150006, China | 
5
 
Beijing Garrison District Haidian retired cadres twenty-sixth, Beijing, China | 
6
 
Department of Traditional Chinese Medicine, Beijing Garrison District Haidian Retired Cadres Twenty- sixth, Beijing, China | 
Publication type: Journal Article
Publication date: 2024-09-01
Bentham Science Publishers Ltd.
scimago Q3
wos Q3
SJR: 0.361
CiteScore: 3.5
Impact factor: 1.7
ISSN: 13862073, 18755402
Organic Chemistry
Drug Discovery
Computer Science Applications
General Medicine
Abstract
Objective::

Endothelial cells (ECs) can provide cell protection for cardiomyocytes (CMs) under hypoxia-reoxygenation (HR) conditions by secreting derived factors. This study aimed to explore the role of curcumin (CUR) in ECs for protecting CMs from HR injury.

Methods::

A co-culture system for ECs and CMs was set up, and subjected to HR. The transcription, expression, and secretion of FGF2 were detected by RT-qPCR, western blot, and ELISA, respectively. siRNAs specifically targeting FGF2 were transfected into ECs. FGF2 receptor- specific inhibitors (AZD4547) were used to treat CMs.

Results::

The co-culture with ECs did not affect the proliferation of CMs, while CUR and ECs co-culture had a synergistic effect on promoting the proliferation of CMs in HR. Furthermore, the co-culture with ECs did not affect the apoptosis and autophagy of CMs in HR. However, the co-culture of ECs after CUR treatment inhibited the apoptosis and autophagy of CMs in HR. CUR treatment significantly enhanced FGF2 mRNA, protein, and secretion levels of ECs in HR. In addition, CUR treatment increased FGF2 levels in the CMs medium in the ECs and CMs co-culture system. The reduction of FGF2 levels in the medium and the inhibition of FGF2 receptors significantly inhibited the proliferation of CMs and significantly promoted the apoptosis and autophagy of CMs in HR.

Conclusion::

Focusing on the protective effects of CUR and ECs on cardiomyocytes is of great significance for the treatment of clinical myocardial HR injury.

Found 
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GOST Copy
Cui J. et al. Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2 // Combinatorial Chemistry and High Throughput Screening. 2024. Vol. 27. No. 14. pp. 2101-2109.
GOST all authors (up to 50) Copy
Cui J., Fan M., Qinwen W. Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2 // Combinatorial Chemistry and High Throughput Screening. 2024. Vol. 27. No. 14. pp. 2101-2109.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.2174/0113862073239166231103102648
UR - https://www.eurekaselect.com/223292/article
TI - Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2
T2 - Combinatorial Chemistry and High Throughput Screening
AU - Cui, Jian-Kun
AU - Fan, Mingming
AU - Qinwen, Wang
PY - 2024
DA - 2024/09/01
PB - Bentham Science Publishers Ltd.
SP - 2101-2109
IS - 14
VL - 27
PMID - 37957857
SN - 1386-2073
SN - 1875-5402
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Cui,
author = {Jian-Kun Cui and Mingming Fan and Wang Qinwen},
title = {Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2},
journal = {Combinatorial Chemistry and High Throughput Screening},
year = {2024},
volume = {27},
publisher = {Bentham Science Publishers Ltd.},
month = {sep},
url = {https://www.eurekaselect.com/223292/article},
number = {14},
pages = {2101--2109},
doi = {10.2174/0113862073239166231103102648}
}
MLA
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MLA Copy
Cui, Jian-Kun, et al. “Curcumin Reduces Hypoxia/Reperfusion Injury of Cardiomyocytes by Stimulating Vascular Endothelial Cells to Secrete FGF2.” Combinatorial Chemistry and High Throughput Screening, vol. 27, no. 14, Sep. 2024, pp. 2101-2109. https://www.eurekaselect.com/223292/article.