Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress
Mikhail Krasavin
1
,
Polina Paramonova
1
Тип публикации: Journal Article
Дата публикации: 2021-02-17
scimago Q2
wos Q2
БС1
SJR: 0.778
CiteScore: 7.7
Impact factor: 3.5
ISSN: 09298673, 1875533X
PubMed ID:
33593249
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
Краткое описание
The last decade has been characterized by the development and approval of pretomanid and delamanid, which are nitroimidazole based drugs for multidrug resistant tuberculosis. This attracted renewed attention to the nitroheterocyclic scaffolds as a source of safe and efficient antimicrobial agents. While the primary focus is still on nitrofurans and nitroimidazoles, well known as bioreducible prodrugs, a number of studies have been published on other 5-membered nitroheteroaromatic compounds. The latter not only show promising antimicrobial activity, but also demonstrate modes of action different from the conventional reductive activation of nitro group. Considering the potential of these efforts to impact in the continuing race against drug-resistant pathogens, herein we review non-furan/imidazole based 5-membered nitroheteroaromatics investigated as antimicrobial agents in 2010-2020.
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Kalinin S. et al. Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress // Current Medicinal Chemistry. 2021. Vol. 28. No. 29. pp. 5926-5982.
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Kalinin S., Vedekhina T., Paramonova P., Krasavin M., Paramonova P. Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress // Current Medicinal Chemistry. 2021. Vol. 28. No. 29. pp. 5926-5982.
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TY - JOUR
DO - 10.2174/0929867328666210216114838
UR - https://doi.org/10.2174/0929867328666210216114838
TI - Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress
T2 - Current Medicinal Chemistry
AU - Kalinin, Stanislav
AU - Vedekhina, Tatiana
AU - Paramonova, Polina
AU - Krasavin, Mikhail
AU - Paramonova, Polina
PY - 2021
DA - 2021/02/17
PB - Bentham Science Publishers Ltd.
SP - 5926-5982
IS - 29
VL - 28
PMID - 33593249
SN - 0929-8673
SN - 1875-533X
ER -
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@article{2021_Kalinin,
author = {Stanislav Kalinin and Tatiana Vedekhina and Polina Paramonova and Mikhail Krasavin and Polina Paramonova},
title = {Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress},
journal = {Current Medicinal Chemistry},
year = {2021},
volume = {28},
publisher = {Bentham Science Publishers Ltd.},
month = {feb},
url = {https://doi.org/10.2174/0929867328666210216114838},
number = {29},
pages = {5926--5982},
doi = {10.2174/0929867328666210216114838}
}
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MLA
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Kalinin, Stanislav, et al. “Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress.” Current Medicinal Chemistry, vol. 28, no. 29, Feb. 2021, pp. 5926-5982. https://doi.org/10.2174/0929867328666210216114838.